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PF-05274857 HCl

Product Name
PF-05274857 HCl
CAS No.
1613439-62-5
Chemical Name
PF-05274857 HCl
Synonyms
PF-05274857 HCl;PF 5274857 hydiochloride;PF-05274857 hydrochloride ≥95%;1-[4-(5'-Chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl-1-piperazinyl]-3-(methylsulfonyl)-1-propanone hydrochloride;1-(4-(5'-Chloro-3,5-dimethyl-[2,4'-bipyridin]-2'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one hydrochloride;1-[4-[5-chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl]piperazin-1-yl]-3-methylsulfonylpropan-1-one:hydrochloride
CBNumber
CB63067569
Molecular Formula
C20H26Cl2N4O3S
Formula Weight
473.41
MOL File
1613439-62-5.mol
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PF-05274857 HCl Property

storage temp. 
Store at -20°C
solubility 
DMSO (Slightly, Heated), Water (Slightly)
form 
Solid
color 
Light Yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15022
Product name
PF-05274857 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$25
Updated
2021/12/16
Cayman Chemical
Product number
15022
Product name
PF-05274857 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$81
Updated
2021/12/16
Cayman Chemical
Product number
15022
Product name
PF-05274857 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$150
Updated
2021/12/16
Cayman Chemical
Product number
15022
Product name
PF-05274857 (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$313
Updated
2021/12/16
TRC
Product number
P227585
Product name
PF-05274857Hydrochloride
Packaging
10mg
Price
$385
Updated
2021/12/16
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PF-05274857 HCl Chemical Properties,Usage,Production

Uses

PF-05274857 is a Smo receptor antagonist which blocks Gli1 transcription in cells stimulated with Shh (sonic hedgehog).

in vivo

PF-5274857 (1-30 mg/kg; p.o. once daily for 6 days) shows robust antitumor efficacy and correlation between PK and PD in medulloblastoma allograft mice models[1].
PF-5274857 (10 mg/kg; i.h.) in the plasma is able to cross the blood-brain barrier in rats within 4 hours postdose[1].
PF-5274857 (10-100 mg/kg; p.o. once daily for 4 days) is able to target Smo in the brain leading to the downregulation of Hh pathway activity in the brain tumor[1].
PF-5274857 (30 mg/kg; p.o. once daily for 34 days) increases the survival rates of primary Ptch+/ p53/ medulloblastoma mice[1].
PF-5274857 (5-30 mg/kg; p.o.) exhibits the apparent volume of distribution of 5.6±0.5 L/kg and the half-life (T1/2) of 1.7±0.1 hours[1].

Animal Model:Severe combined immunodeficient (SCID)-beige mice (6-8 weeks old) are genetically engineered[1]
Dosage:0, 1, 5, 10, 30 mg/kg
Administration:P.o. once daily for 6 days
Result:Showed robust antitumor activity with an in vivo IC50 of 8.9±2.6 nM.
Animal Model:Severe combined immunodeficient (SCID)-beige mice (6-8 weeks old)[1]
Dosage:0, 5, 10, 30 mg/kg (Pharmacokinetic Analysis)
Administration:A single p.o.
Result:The apparent volume of distribution of 5.6±0.5 L/kg; the half-life (T1/2) of 1.7±0.1 hours.

storage

Desiccate at RT

PF-05274857 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-05274857 HCl Suppliers

China 23 United Kingdom 2 United States 3 USA 1 Global 29
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4800
Advantage
55
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9543
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32470
Advantage
58

1613439-62-5, PF-05274857 HClRelated Search:


  • PF-05274857 HCl
  • 1-[4-[5-chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl]piperazin-1-yl]-3-methylsulfonylpropan-1-one:hydrochloride
  • 1-[4-(5'-Chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl-1-piperazinyl]-3-(methylsulfonyl)-1-propanone hydrochloride
  • PF-05274857 hydrochloride ≥95%
  • PF 5274857 hydiochloride
  • 1-(4-(5'-Chloro-3,5-dimethyl-[2,4'-bipyridin]-2'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one hydrochloride
  • 1613439-62-5