(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate

Product Name: (2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate
CAS No.: 1174020-64-4
Chemical Name: (2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate
Synonyms: EOS-61526;Relebactam INT;(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate;tert-Butyl4-((2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate;tert-butyl-4-((1R,2S,5R)-6-(hydroxy-7-oxo-1,6-diazabicyclo-[3.2.1]octane2-carboxamido)-piperidine-1-carboxylate;4-[[[(1R,2S,5R)-6-Hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl]amino]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester;1-Piperidinecarboxylic acid, 4-[[[(1R,2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl]amino]-, 1,1-dimethylethyl ester
CBNumber: CB63070639
Molecular Formula: C17H28N4O5
Formula Weight: 368.43
MOL File: 1174020-64-4.mol

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(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate Property

Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 10.28±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ark Pharm

Product number: AK600678
Product name: tert-Butyl4-((1R,2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate
Purity: 97%
Packaging: 1g
Price: $68
Updated: 2021/12/16

Ark Pharm

Product number: AK600678
Product name: tert-Butyl4-((1R,2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate
Purity: 97%
Packaging: 100mg
Price: $18
Updated: 2021/12/16

Ambeed

Product number: A142522
Product name: tert-Butyl4-((1R,2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate
Purity: 97%
Packaging: 250mg
Price: $24
Updated: 2021/12/16

Ambeed

Product number: A142522
Product name: tert-Butyl4-((1R,2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate
Purity: 97%
Packaging: 1g
Price: $59
Updated: 2021/12/16

Ambeed

Product number: A142522
Product name: tert-Butyl4-((1R,2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate
Purity: 97%
Packaging: 100mg
Price: $15
Updated: 2021/12/16

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(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate Chemical Properties,Usage,Production

Synthesis

1174020-63-3

1174020-64-4

Example 2: Preparation of tert-butyl 4-((1R,2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carbonylamino)piperidine-1-carboxylate (Compound 1) Tert-butyl 4-[[[(1R,2S,5R)-7-oxo-6-(phenylmethoxy)-1,6-diazabicyclo[3.2.1]octan-2-yl]carbonyl]amino]-1 -piperidinecarboxylate prepared according to the method described in Example 1 was used as starting material for the following hydrodebenzylation reaction. Compound 1 prepared using triphosgene was used as a control. Operating Procedure: 1. To a dry and clean autoclave was added compound 1 (3.0 g) and tetrahydrofuran (THF, 72 mL). 2. Add palladium/carbon catalyst (Pd/C, 10 wt% loading) to the reaction mixture. 3. Adjusted the autoclave internal pressure to 50 psig (total internal pressure). 4. age the reaction mixture for 4 hours at 25°C and 50 psig to ensure complete conversion. 5. Upon completion of the reaction, the reaction was vented and filtered to remove the Pd/C catalyst, and the catalyst was washed with THF (5 x 15 mL). 6. The combined organic phases were concentrated to 1/10 of the original volume, and then the solvent was replaced with isopropyl acetate (IPAc, 45 mL) to give a product slurry. 7. The slurry was continued to be stirred for 4 hours. 8. The reaction mixture was filtered and the solid product was collected and washed with IPAc (9 mL). 9. The resulting white solid was dried under vacuum and purged with nitrogen (N2) to afford the target product tert-butyl 4-((1R,2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate (~95% yield, >98% LCAP purity). The spectral data of the product are in agreement with those reported in the literature (see Mangion et al., 2011, Org. Lett. 13: 5480). Table 1 compares the effect of the method employed in the hydroxyl debenzylation reaction of the present invention (i.e., use of silicone-containing compounds and CDI) with that of a previously disclosed method (i.e., use of triphosgene) for the preparation of compound 1.

References

[1] Patent: WO2016/89718, 2016, A1. Location in patent: Page/Page column 22-23
[2] Organic Letters, 2014, vol. 16, # 1, p. 174 - 177
[3] Patent: WO2014/200786, 2014, A1. Location in patent: Page/Page column 26
[4] Patent: WO2009/91856, 2009, A2. Location in patent: Page/Page column 60
[5] Patent: WO2009/91856, 2009, A2. Location in patent: Page/Page column 62

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate Suppliers

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1174020-64-4, (2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfateRelated Search:

(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate

tert-butyl-4-((1R,2S,5R)-6-(hydroxy-7-oxo-1,6-diazabicyclo-[3.2.1]octane2-carboxamido)-piperidine-1-carboxylate

4-[[[(1R,2S,5R)-6-Hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl]amino]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

EOS-61526

1-Piperidinecarboxylic acid, 4-[[[(1R,2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl]amino]-, 1,1-dimethylethyl ester

Relebactam INT

tert-Butyl4-((2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate

1174020-64-4

C17H28N4O5