2-formyl-1H-indole-6-carbonitrile
- Product Name
- 2-formyl-1H-indole-6-carbonitrile
- CAS No.
- 104291-63-6
- Chemical Name
- 2-formyl-1H-indole-6-carbonitrile
- Synonyms
- 2-formyl-1H-indole-6-carbonitrile;1H-Indole-6-carbonitrile, 2-formyl-
- CBNumber
- CB63083774
- Molecular Formula
- C10H6N2O
- Formula Weight
- 170.17
- MOL File
- 104291-63-6.mol
2-formyl-1H-indole-6-carbonitrile Property
- Boiling point:
- 429.6±25.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 13.22±0.30(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CHM0388222
- Product name
- 2-FORMYL-1H-INDOLE-6-CARBONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.04
- Updated
- 2021/12/16
- Product number
- 0972AA
- Product name
- 2-Formyl-1H-indole-6-carbonitrile
- Packaging
- 1g
- Price
- $608
- Updated
- 2021/12/16
- Product number
- 0972AA
- Product name
- 2-Formyl-1H-indole-6-carbonitrile
- Packaging
- 5g
- Price
- $2121
- Updated
- 2021/12/16
- Product number
- AA0091J0
- Product name
- 2-Formyl-1h-indole-6-carbonitrile
- Purity
- 96%
- Packaging
- 100mg
- Price
- $146
- Updated
- 2021/12/16
- Product number
- AA0091J0
- Product name
- 2-Formyl-1h-indole-6-carbonitrile
- Purity
- 96%
- Packaging
- 250mg
- Price
- $198
- Updated
- 2021/12/16
2-formyl-1H-indole-6-carbonitrile Chemical Properties,Usage,Production
Synthesis
104291-65-8
104291-63-6
The general procedure for the synthesis of 2-formyl-1H-indole-6-carbonitrile from 2-hydroxymethylindole-6-carbonitrile (18; 2.10 g, 12.2 mmol) was as follows: 2-hydroxymethylindole-6-carbonitrile was dissolved in acetone (50 mL) and manganese dioxide (3.15 g, 36 mmol) was added. The reaction mixture was stirred at room temperature for 16 hours, followed by the addition of manganese dioxide (1.05 g, 12 mmol) and continued stirring for 24 hours. Upon completion of the reaction, the insoluble solids were removed by diatomaceous earth filtration and the solid residue was washed with acetone (20 mL). The filtrates were combined and concentrated under reduced pressure. The concentrated crude product was adsorbed onto silica gel (~100 mL, uncompressed) and eluted with ethyl acetate (250 mL) until product was no longer detected in the eluate. The eluate containing product was collected and concentrated under reduced pressure. The crude product was recrystallized by boiling a solvent mixture of dichloromethane/hexane to give 1.14 g (55% yield) of the product as an olive colored powder. Thin layer chromatography (TLC) analysis showed an Rf value of 0.45 (unfolding agent ratio 2:1 hexane/ethyl acetate). The 1H NMR (DMSO-d6) data of the product were as follows: δ 12.50 (s, 1H), 9.97 (s, 1H), 7.96-7.91 (m, 2H), 7.52-7.42 (m, 2H).
References
[1] Liebigs Annalen der Chemie, 1986, # 3, p. 438 - 455
[2] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 24, p. 7790 - 7806
2-formyl-1H-indole-6-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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