3-Bromo-5-chloro-1H-indazole
- Product Name
- 3-Bromo-5-chloro-1H-indazole
- CAS No.
- 885521-43-7
- Chemical Name
- 3-Bromo-5-chloro-1H-indazole
- Synonyms
- 3-BROMO-5-CHLORO (1H)INDAZOLE;1H-Indazole, 3-bromo-5-chloro-
- CBNumber
- CB6308555
- Molecular Formula
- C7H4BrClN2
- Formula Weight
- 231.48
- MOL File
- 885521-43-7.mol
3-Bromo-5-chloro-1H-indazole Property
- Density
- 1.878
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Light yellow to yellow Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B593993
- Product name
- 3-Bromo-5-chloro-1H-indazole
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB146249
- Product name
- 3-Bromo-5-chloro-1H-indazole
- Packaging
- 25mg
- Price
- $51
- Updated
- 2021/12/16
- Product number
- FB146249
- Product name
- 3-Bromo-5-chloro-1H-indazole
- Packaging
- 50mg
- Price
- $89
- Updated
- 2021/12/16
- Product number
- FB146249
- Product name
- 3-Bromo-5-chloro-1H-indazole
- Packaging
- 100mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- Y4530
- Product name
- 3-Bromo-5-chloro-1H-indazole
- Packaging
- 1g
- Price
- $251
- Updated
- 2021/12/16
3-Bromo-5-chloro-1H-indazole Chemical Properties,Usage,Production
Synthesis
698-26-0
885521-43-7
General procedure for the synthesis of 3-bromo-5-chloro-1H-indazole from 5-chloro-1H-indazole: 5-chloro-1H-indazole (2.5 g, 16.1 mmol) was dissolved in dichloromethane (150 mL) and N-bromosuccinimide (2.9 g, 16.6 mmol) was added. The reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure and the residue was dissolved in ethyl acetate (100 mL) and washed sequentially with water (50 mL) and saturated saline (50 mL). The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford 3-bromo-5-chloro-1H-indazole (3.7 g, 94% yield) as a brown solid. The product was confirmed by 1H NMR (DMSO-d6, 400MHz): δ 13.63 (s, 1H), 7.67-7.59 (m, 2H), 7.49-7.44 (m, 1H).TLC analytical conditions: 50% ethyl acetate/heptane (Rf = 0.43).
References
[1] Patent: WO2017/31325, 2017, A1. Location in patent: Paragraph 0764
[2] Synthesis, 2011, # 16, p. 2651 - 2663
[3] Patent: US2013/281433, 2013, A1. Location in patent: Paragraph 1088
3-Bromo-5-chloro-1H-indazole Preparation Products And Raw materials
Raw materials
Preparation Products
3-Bromo-5-chloro-1H-indazole Suppliers
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
View Lastest Price from 3-Bromo-5-chloro-1H-indazole manufacturers
- Product
- 3-Bromo-5-chloro-1H-indazole 885521-43-7
- Price
- US $100.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2021-09-13
- Product
- 3-Bromo-5-chloro-1H-indazole 885521-43-7
- Price
- US $100.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2021-09-14
- Product
- 3-bromo-5-chloro-2H-indazole 885521-43-7
- Price
- US $100.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 98%
- Supply Ability
- 10KG
- Release date
- 2021-09-15