6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole

Product Name: 6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole
CAS No.: 1254036-71-9
Chemical Name: 6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole
Synonyms: CS-2340;Nemiralisib;GSK2269557 (free base);Nemiralisib(GSK2269557);gsk2269557(Nemiralisib);GSK 2269557;GSK-2269557;PI3Kδ inhibitor GS2269557;PI3Kδ inhibitor GS2269557;Nemiralisib (GSK2269557 free base);6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole
CBNumber: CB63106826
Molecular Formula: C26H28N6O
Formula Weight: 440.54
MOL File: 1254036-71-9.mol

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6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Property

Boiling point:: 706.2±70.0 °C(Predicted)
Density: 1.281±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 33.33 mg/mL (75.66 mM)
form: Solid
pka: 12.90±0.40(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5683
Product name: Nemiralisib
Purity: 99.50%
Packaging: 1mg
Price: $84
Updated: 2021/12/16

ChemScene

Product number: CS-5683
Product name: Nemiralisib
Purity: 99.50%
Packaging: 5mg
Price: $144
Updated: 2021/12/16

ChemScene

Product number: CS-5683
Product name: Nemiralisib
Purity: 99.50%
Packaging: 10mg
Price: $228
Updated: 2021/12/16

Matrix Scientific

Product number: 148001
Product name: 1H-Indazole
Packaging: 5mg
Price: $482
Updated: 2021/12/16

ChemScene

Product number: CS-5683
Product name: Nemiralisib
Purity: 99.50%
Packaging: 25mg
Price: $492
Updated: 2021/12/16

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6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Chemical Properties,Usage,Production

Biological Activity

Nemiralisib, also known as GSK-2269557, is a potent and selective PI3Kδ inhibitor (pKi=9.9).

in vivo

Nemiralisib has relatively low oral bioavailability (F=2%), in vivo clearance is 28 mL/min/kg, but high volume distribution, 6.3 L/kg. 0.3-1 μMGSK-2269557 induction concentration Dependent QT interval and T_pe prolongation, 1 μM GSK-2269557 resulted in prolongation of the ORS wave, during which no torsades de pointes arrhythmia was observed.

target

Target	Value
PI3Kδ (Cell-free assay)	9.9(pKi)

6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Preparation Products And Raw materials

Raw materials

Preparation Products

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6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Suppliers

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1254036-71-9, 6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazoleRelated Search:

6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole

GSK2269557 (free base)

1H-Indazole, 6-(1H-indol-4-yl)-4-[5-[[4-(1-methylethyl)-1-piperazinyl]methyl]-2-oxazolyl]-

PI3Kδ inhibitor GS2269557

CS-2340

gsk2269557(Nemiralisib)

Nemiralisib(GSK2269557)

Nemiralisib (GSK2269557 free base)

GSK 2269557;GSK-2269557

Nemiralisib

PI3Kδ inhibitor GS2269557

2-(6-(1H-Indol-4-yl)-1H-indazol-4-yl)-5-((4-isopropylpiperazin-1-yl)methyl)oxazole

1254036-71-9

C26H28N6O