ChemicalBook > CAS DataBase List > Cyclic Arg-Gly-Asp-D-Tyr-Lys

Cyclic Arg-Gly-Asp-D-Tyr-Lys

Product Name
Cyclic Arg-Gly-Asp-D-Tyr-Lys
CAS No.
250612-42-1
Chemical Name
Cyclic Arg-Gly-Asp-D-Tyr-Lys
Synonyms
Cyclo(RGDyK) TFA;Cyclic Arg-Gly-Asp-D-Tyr-Lys;CCyclic Arg-Gly-Asp-D-Tyr-Lys;Cyclo(RGDyK) trifluoroacetate;Cyclo(RGDyK) (Cyclic Arg-Gly-Asp-D-Tyr-Lys);Cyclo(RGDyK) trifluoroacetate, 10 mM in DMSO;Integrin,Cyclo(RGDyK) trifluoroacetate,inhibit,Inhibitor;Cyclo(L-arginylglycyl-L-α-aspartyl-D-tyrosyl-L-lysyl) di2,2,2-Trifluoroacetic acid salt;2,2,2-Trifluoroacetic acid compound with 2-((2S,5R,8S,11S)-8-(4-aminobutyl)-11-(3-guanidinopropyl)-5-(4-hydroxybenzyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid (2:1)
CBNumber
CB63121443
Molecular Formula
C29H42F3N9O10
Formula Weight
733.7
MOL File
250612-42-1.mol
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Cyclic Arg-Gly-Asp-D-Tyr-Lys Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in DMSO
form 
Solid
color 
White to off-white
Sequence
cyclo(Arg-Gly-Asp-{d-Tyr}-Lys)
InChIKey
KTQFOJMRRQLTAN-CNDMKARKNA-N
SMILES
C(F)(F)(F)C(=O)O.C(C1C=CC(O)=CC=1)[C@H]1NC([C@@H](NC(CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC1=O)=O)CC(=O)O)=O |&1:15,18,25,36,r|
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0019707
Product name
Cyclo(RGDyK)trifluoroacetate
Purity
99.13%
Packaging
5mg
Price
$110
Updated
2021/12/16
ChemScene
Product number
CS-0019707
Product name
Cyclo(RGDyK)trifluoroacetate
Purity
99.13%
Packaging
10mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-0019707
Product name
Cyclo(RGDyK)trifluoroacetate
Purity
99.13%
Packaging
25mg
Price
$360
Updated
2021/12/16
ChemScene
Product number
CS-0019707
Product name
Cyclo(RGDyK)trifluoroacetate
Purity
99.13%
Packaging
50mg
Price
$590
Updated
2021/12/16
ChemScene
Product number
CS-0019707
Product name
Cyclo(RGDyK)trifluoroacetate
Purity
99.13%
Packaging
100mg
Price
$890
Updated
2021/12/16
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Cyclic Arg-Gly-Asp-D-Tyr-Lys Chemical Properties,Usage,Production

Uses

Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.

Biological Activity

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.

in vitro

Cyclo(RGDyK) showed higher affinity and selectivity for αVβ3 than αVβ5 and αIIbβ3. Cyclo(RGDyK)-bound micelles (TPM) promoted cell-specific uptake of DiI by B16-F10 cells and HUVECs through integrin-mediated endocytosis compared to Cyclo(RGDyK)-free micelles (NPM).

in vivo

Cyclo(RGDyK) (1 nmol, iv) inhibits the increase in αVβ3 integrin expression in the intima of left stenotic carotid arteries in apoE?/? mice.

target

TargetValue
αVβ3 integrin 20 nM

IC 50

αvβ3: 20 nM (IC50)

References

[1] Haubner R, et al. Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics. J Nucl Med. 2001 Feb;42(2):326-36. PMID:11216533

Cyclic Arg-Gly-Asp-D-Tyr-Lys Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cyclic Arg-Gly-Asp-D-Tyr-Lys manufacturers

Career Henan Chemical Co
Product
Cyclic Arg-Gly-Asp-D-Tyr-Lys 250612-42-1
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-16

250612-42-1, Cyclic Arg-Gly-Asp-D-Tyr-LysRelated Search:


  • Cyclic Arg-Gly-Asp-D-Tyr-Lys
  • Cyclo(RGDyK) trifluoroacetate
  • CCyclic Arg-Gly-Asp-D-Tyr-Lys
  • Cyclo(L-arginylglycyl-L-α-aspartyl-D-tyrosyl-L-lysyl) di2,2,2-Trifluoroacetic acid salt
  • Cyclo(RGDyK) TFA
  • Integrin,Cyclo(RGDyK) trifluoroacetate,inhibit,Inhibitor
  • 2,2,2-Trifluoroacetic acid compound with 2-((2S,5R,8S,11S)-8-(4-aminobutyl)-11-(3-guanidinopropyl)-5-(4-hydroxybenzyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid (2:1)
  • Cyclo(RGDyK) trifluoroacetate, 10 mM in DMSO
  • Cyclo(RGDyK) (Cyclic Arg-Gly-Asp-D-Tyr-Lys)
  • 250612-42-1