Cyclic Arg-Gly-Asp-D-Tyr-Lys

ChemicalBook > CAS DataBase List > Cyclic Arg-Gly-Asp-D-Tyr-Lys

Cyclic Arg-Gly-Asp-D-Tyr-Lys

Product Name: Cyclic Arg-Gly-Asp-D-Tyr-Lys
CAS No.: 250612-42-1
Chemical Name: Cyclic Arg-Gly-Asp-D-Tyr-Lys
Synonyms: Cyclo(RGDyK) TFA;Cyclic Arg-Gly-Asp-D-Tyr-Lys;CCyclic Arg-Gly-Asp-D-Tyr-Lys;Cyclo(RGDyK) trifluoroacetate;Integrin,Cyclo(RGDyK) trifluoroacetate,inhibit,Inhibitor;Cyclo(L-arginylglycyl-L-α-aspartyl-D-tyrosyl-L-lysyl) di2,2,2-Trifluoroacetic acid salt;2,2,2-Trifluoroacetic acid compound with 2-((2S,5R,8S,11S)-8-(4-aminobutyl)-11-(3-guanidinopropyl)-5-(4-hydroxybenzyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid (2:1)
CBNumber: CB63121443
Molecular Formula: C29H42F3N9O10
Formula Weight: 733.7
MOL File: 250612-42-1.mol

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Cyclic Arg-Gly-Asp-D-Tyr-Lys Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Soluble in DMSO

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0019707
Product name: Cyclo(RGDyK)trifluoroacetate
Purity: 99.13%
Packaging: 5mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-0019707
Product name: Cyclo(RGDyK)trifluoroacetate
Purity: 99.13%
Packaging: 10mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-0019707
Product name: Cyclo(RGDyK)trifluoroacetate
Purity: 99.13%
Packaging: 25mg
Price: $360
Updated: 2021/12/16

ChemScene

Product number: CS-0019707
Product name: Cyclo(RGDyK)trifluoroacetate
Purity: 99.13%
Packaging: 50mg
Price: $590
Updated: 2021/12/16

ChemScene

Product number: CS-0019707
Product name: Cyclo(RGDyK)trifluoroacetate
Purity: 99.13%
Packaging: 100mg
Price: $890
Updated: 2021/12/16

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Cyclic Arg-Gly-Asp-D-Tyr-Lys Chemical Properties,Usage,Production

Biological Activity

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.

in vitro

Cyclo(RGDyK) showed higher affinity and selectivity for αVβ3 than αVβ5 and αIIbβ3. Cyclo(RGDyK)-bound micelles (TPM) promoted cell-specific uptake of DiI by B16-F10 cells and HUVECs through integrin-mediated endocytosis compared to Cyclo(RGDyK)-free micelles (NPM).

in vivo

Cyclo(RGDyK) (1 nmol, iv) inhibits the increase in αVβ3 integrin expression in the intima of left stenotic carotid arteries in apoE?/? mice.

target

Target	Value
αVβ3 integrin	20 nM

Cyclic Arg-Gly-Asp-D-Tyr-Lys Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cyclic Arg-Gly-Asp-D-Tyr-Lys manufacturers

Career Henan Chemical Co

Product: Cyclic Arg-Gly-Asp-D-Tyr-Lys 250612-42-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-16

250612-42-1, Cyclic Arg-Gly-Asp-D-Tyr-LysRelated Search:

Cyclic Arg-Gly-Asp-D-Tyr-Lys

Cyclo(RGDyK) trifluoroacetate

CCyclic Arg-Gly-Asp-D-Tyr-Lys

Cyclo(L-arginylglycyl-L-α-aspartyl-D-tyrosyl-L-lysyl) di2,2,2-Trifluoroacetic acid salt

Cyclo(RGDyK) TFA

Integrin,Cyclo(RGDyK) trifluoroacetate,inhibit,Inhibitor

2,2,2-Trifluoroacetic acid compound with 2-((2S,5R,8S,11S)-8-(4-aminobutyl)-11-(3-guanidinopropyl)-5-(4-hydroxybenzyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid (2:1)

250612-42-1