tert-butyl 1-oxa-5-azaspiro[2.3]hexane-5-carboxylate

Product Name: tert-butyl 1-oxa-5-azaspiro[2.3]hexane-5-carboxylate
CAS No.: 934664-42-3
Chemical Name: tert-butyl 1-oxa-5-azaspiro[2.3]hexane-5-carboxylate
Synonyms: 5-Boc-1-oxa-5-azaspiro[2.3]hexane;tert-butyl 1-oxa-5-azaspiro[2.3]hexane-5-carboxylate;2-Methyl-2-propanyl 1-oxa-5-azaspiro[2.3]hexane-5-carboxylate;1-oxa-5-aza-spiro[2.3]hexane-5-carboxylic acid tert-butyl ester;2-Oxa-5-azaspiro[2.3]hexane-5-carboxylic acid tert. butyl ester;1-Oxa-5-azaspiro[2.3]hexane-5-carboxylic acid, 1,1-dimethylethyl ester
CBNumber: CB63122066
Molecular Formula: C9H15NO3
Formula Weight: 185.22
MOL File: 934664-42-3.mol

More

Less

tert-butyl 1-oxa-5-azaspiro[2.3]hexane-5-carboxylate Property

Boiling point:: 259.5±33.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
pka: -0.98±0.20(Predicted)
Appearance: Colorless to light yellow Liquid

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

TRC

Product number: T205780
Product name: tert-Butyl1-Oxa-5-azaspiro[2.3]hexane-5-carboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM1052461
Product name: TERT-BUTYL-1-OXA-5-AZASPIRO[2.3]HEXANE-5-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $450.67
Updated: 2021/12/16

Chemenu

Product number: CM219144
Product name: tert-Butyl1-oxa-5-azaspiro[2.3]hexane-5-carboxylate
Purity: 97%
Packaging: 1g
Price: $583
Updated: 2021/12/16

Chemenu

Product number: CM219144
Product name: tert-Butyl1-oxa-5-azaspiro[2.3]hexane-5-carboxylate
Purity: 97%
Packaging: 5g
Price: $1748
Updated: 2021/12/16

Labseeker

Product number: SC-91489
Product name: 2-OXA-5-AZASPIRO[2.3]HEXANE-5-CARBOXYLICACIDTERT-BUTYLESTER
Purity: 95
Packaging: 5g
Price: $1916
Updated: 2021/12/16

More

Less

tert-butyl 1-oxa-5-azaspiro[2.3]hexane-5-carboxylate Chemical Properties,Usage,Production

Synthesis

934664-41-2

934664-42-3

General procedure for the synthesis of tert-butyl 1-oxa-5-azaspiro[2.3]hexane-5-carboxylate from 1-Boc-3-methyleneazetidine: To a solution of 1,1-dimethylethyl 3-chloromethyl-1,3-methylvinyl-1-carboxylate (2.96 g, 17.5 mmol) in chloroform (180 mL) was added 3-chloroperoxybenzoic acid (77%. 13.9 g, 62.0 mmol). The reaction mixture was stirred at room temperature for 2 days. Upon completion of the reaction, the reaction was quenched with a 1:1 mixture of 10% sodium thiosulfate and saturated sodium bicarbonate solution (150 mL). The organic phase was separated, dried with anhydrous sodium sulfate, filtered and concentrated to give an oily residue. This residue was purified by fast chromatography (eluent: 15-50% ethyl acetate/hexane) to afford 1,1-dimethylethyl-1-oxa-5-azaspiro[2.3]hexane-5-carboxylate (1.65 g, 51% yield). The product was analyzed by GC-MS with molecular formula C9H15NO3 and molecular ion peak m/z of 185.

References

[1] Patent: WO2008/76415, 2008, A1. Location in patent: Page/Page column 340
[2] Patent: WO2008/124085, 2008, A2. Location in patent: Page/Page column 190
[3] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 5, p. 416 - 421
[4] Patent: WO2010/22076, 2010, A1. Location in patent: Page/Page column 128
[5] Patent: WO2017/107979, 2017, A1. Location in patent: Paragraph 1720

tert-butyl 1-oxa-5-azaspiro[2.3]hexane-5-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

tert-butyl 1-oxa-5-azaspiro[2.3]hexane-5-carboxylate Suppliers

China 40 United States 2 Global 42

Shanghai Raise Chemical Technology Co.,Ltd

Tel: 15026594951
Fax: 0556-5030632
Email: rs@raise-chem.com
Country: China
ProdList: 4712
Advantage: 55

Shanghai Hobor Chemical Co., Ltd

Tel: 021-57790084 13918007836
Fax: 021-51685238
Email: sales@hoborchem.com
Country: China
ProdList: 438
Advantage: 60

Taizhou GreenChem Pharmaceutical Co., Ltd.

Tel: 0514-86654616 15366892466
Email: greenchem@tzglmk.com
Country: China
ProdList: 498
Advantage: 56

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9445
Advantage: 55

Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 18930833303 18930833303
Fax: +86 (21) 2024-2659
Email: sales@changyanchem.cn
Country: China
ProdList: 5001
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Huaxing Biological Technology Co., Ltd.

Tel: 18621295758; 18621295758
Fax: -QQ:1449085402
Email: 1449085402@qq.com
Country: China
ProdList: 1972
Advantage: 55

Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
Advantage: 58

SHANGHAI FDC-CHEMICAL CO.,LTD

Tel: 021-61469567 13482353728
Fax: 021-61161605
Email: sales@fdc-chemical.com
Country: China
ProdList: 9977
Advantage: 58

Nanjing SynTitan Pharmaceutical Co., Ltd.

Tel: 025-57027686 17372956142
Fax: 025-57027686
Email: li_lan@syntitan.com
Country: China
ProdList: 10000
Advantage: 58

934664-42-3, tert-butyl 1-oxa-5-azaspiro[2.3]hexane-5-carboxylateRelated Search:

tert-butyl 1-oxa-5-azaspiro[2.3]hexane-5-carboxylate

2-Methyl-2-propanyl 1-oxa-5-azaspiro[2.3]hexane-5-carboxylate

1-oxa-5-aza-spiro[2.3]hexane-5-carboxylic acid tert-butyl ester

1-Oxa-5-azaspiro[2.3]hexane-5-carboxylic acid, 1,1-dimethylethyl ester

2-Oxa-5-azaspiro[2.3]hexane-5-carboxylic acid tert. butyl ester

5-Boc-1-oxa-5-azaspiro[2.3]hexane

934664-42-3