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XMU-MP-1

Product Name
XMU-MP-1
CAS No.
2061980-01-4
Chemical Name
XMU-MP-1
Synonyms
4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino)benzenesulfonamide;CS-2590;XMU-MP-1;XUM-MP- 1;PubChem ID: 121499143;XMU MP 1,Inhibitor,Hippo (MST),inhibit,XMUMP1;4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide;Benzenesulfonamide, 4-[(6,10-dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]-
CBNumber
CB63122127
Molecular Formula
C17H16N6O3S2
Formula Weight
416.48
MOL File
2061980-01-4.mol
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XMU-MP-1 Property

Boiling point:
714.8±70.0 °C(Predicted)
Density 
1.523±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
≥41.6 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
form 
powder
pka
9.77±0.12(Predicted)
color 
white to beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2233
Product name
XMU-MP-1 hydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$206
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2233
Product name
XMU-MP-1 hydrochloride
Purity
≥98% (HPLC)
Packaging
25mg
Price
$328.8
Updated
2024/03/01
Cayman Chemical
Product number
22083
Product name
XMU-MP-1
Purity
≥98%
Packaging
1mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
22083
Product name
XMU-MP-1
Purity
≥98%
Packaging
5mg
Price
$175
Updated
2024/03/01
Cayman Chemical
Product number
22083
Product name
XMU-MP-1
Purity
≥98%
Packaging
10mg
Price
$308
Updated
2024/03/01
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XMU-MP-1 Chemical Properties,Usage,Production

Description

XMU-MP-1 is an inhibitor of the pro-apoptotic, sterile 20-like kinases MST1 and 2 (IC50s = 71.1 and 38.1 nM, respectively). It is selective for MST1 and 2 over a panel of 468 kinases at a concentration of 1 μM. XMU-MP-1 inhibits phosphorylation of MOB1, LATS1 and 2, and YAP in HepG2 cells as well as MST1 and 2 autophosphorylation in RAW 264.7, U2OS, SW480, RPE1, SNU423, and HepG2 cells in a concentration-dependent manner. It also prevents cell death induced by overexpression of MST2. XMU-MP-1 (1 mg/kg) enhances liver regeneration in mice post partial hepatectomy and reduces liver fibrosis in a mouse model of chronic liver injury.

Uses

XMU-?MP-?1 an MST1/2 inhibitor.

storage

Store at -20°C

References

1. fuqin fan, zhixiang he, lu-lu kong, et al. pharmacological targeting of kinases mst1 and mst2 augments tissue repair and regeneration. science translational medicine 17 aug 2016: vol. 8, issue 352, pp. 352ra108.

XMU-MP-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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XMU-MP-1 Suppliers

China 69 India 1 United Kingdom 1 United States 9 USA 1 Global 81
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

2061980-01-4, XMU-MP-1Related Search:


  • XMU-MP-1
  • 4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino)benzenesulfonamide
  • PubChem ID: 121499143
  • CS-2590
  • 4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide
  • Benzenesulfonamide, 4-[(6,10-dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]-
  • XMU MP 1,Inhibitor,Hippo (MST),inhibit,XMUMP1
  • XUM-MP- 1
  • 2061980-01-4
  • API