(S)-5-(BROMOMETHYL)-2-PYRROLIDINONE

Product Name: (S)-5-(BROMOMETHYL)-2-PYRROLIDINONE
CAS No.: 72479-05-1
Chemical Name: (S)-5-(BROMOMETHYL)-2-PYRROLIDINONE
Synonyms: (S)-5-(BromomethyL;5β-(Bromomethyl)pyrrolidine-2-one;(S)-5-(BROMOMETHYL)-2-PYRROLIDONE;(S)-5-BROMOMETHYL-2-OXOPYRROLIDINE;(5S)-5-(Brommethyl)pyrrolidin-2-on;(S)-5-(BROMOMETHYL)-2-PYRROLIDINONE;(S)-5-(broMoMethyl)pyrrolidin-2-one;(5S)-5-(bromomethyl)-2-pyrrolidinone;(5S)-5-(broMoMethyl)pyrrolidin-2-one;(5S)-5β-(Bromomethyl)pyrrolidine-2-one
CBNumber: CB6312743
Molecular Formula: C5H8BrNO
Formula Weight: 178.03
MOL File: 72479-05-1.mol

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(S)-5-(BROMOMETHYL)-2-PYRROLIDINONE Property

Melting point:: 75-79°C
Boiling point:: 102-106 °C(Press: 0.1 Torr)
Density: 1.541±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 15.39±0.40(Predicted)
form: powder
Appearance: Off-white to light brown Solid
optical activity: [α]22/D 30.0°, c = 0.5 in ethanol

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-43-36-22
Safety Statements: 26-36/37/39-36/37
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 715611
Product name: (S)-5-(Bromomethyl)-2-pyrrolidinone
Purity: 96%
Packaging: 250mg
Price: $59.2
Updated: 2023/06/20

TRC

Product number: B697653
Product name: (S)-5-(Bromomethyl)-2-pyrrolidinone
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK376587
Product name: (S)-(+)-5-Bromomethyl-2-pyrrolidinone
Purity: 97%
Packaging: 250mg
Price: $18
Updated: 2021/12/16

Chem-Impex

Product number: 41530
Product name: (S)-5-(Bromomethyl)-2-pyrrolidinone,95.5%(GC)
Purity: 95.5%(GC)
Packaging: 250MG
Price: $47.04
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK376587
Product name: (S)-(+)-5-Bromomethyl-2-pyrrolidinone
Purity: 97%
Packaging: 1g
Price: $60
Updated: 2021/12/16

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(S)-5-(BROMOMETHYL)-2-PYRROLIDINONE Chemical Properties,Usage,Production

Chemical Properties

White to tan powder

Synthesis

17342-08-4

72479-05-1

General procedure for the synthesis of (S)-5-bromomethyl-2-pyrrolidinone from (S)-(+)-5-hydroxymethyl-2-pyrrolidinone: First, (S)-5-hydroxymethyl-2-pyrrolidinone (1.58 g, 13.7 mmol) and triphenylphosphine (3.97 g, 15.1 mmol) were suspended in anhydrous acetonitrile (20 mL) and stirred at 0 °C. Subsequently, a solution of carbon tetrabromide (5.02 g, 15.1 mmol, 1.1 eq.) dissolved in 8 mL of anhydrous acetonitrile was added slowly and dropwise. The reaction mixture gradually changed to a clarified solution, followed by stirring at room temperature overnight. Upon completion of the reaction, the solvent was removed by rotary evaporation and the residue was purified by Biotage fast chromatography to afford the target product (S)-5-bromomethyl-2-pyrrolidinone as a white solid (2.32 g, 95% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CD3OD): δ 6.18 (br s, 1H), 3.94-3.97 (m, 1H), 3.28-3.44 (m, 2H), 2.27-2.49 (m, 3H), 1.82-1.91 (m, 1H).

References

[1] Helvetica Chimica Acta, 1996, vol. 79, # 4, p. 961 - 972
[2] Patent: WO2012/21712, 2012, A1. Location in patent: Page/Page column 162
[3] Journal of Organic Chemistry, 1980, vol. 45, # 5, p. 815 - 818
[4] Journal of the American Chemical Society, 1990, vol. 112, # 2, p. 838 - 845
[5] Tetrahedron, 2013, vol. 69, # 27-28, p. 5647 - 5659

(S)-5-(BROMOMETHYL)-2-PYRROLIDINONE Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-5-(BROMOMETHYL)-2-PYRROLIDINONE Suppliers

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View Lastest Price from (S)-5-(BROMOMETHYL)-2-PYRROLIDINONE manufacturers

Career Henan Chemical Co

Product: (S)-5-(BROMOMETHYL)-2-PYRROLIDINONE 72479-05-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-24

72479-05-1, (S)-5-(BROMOMETHYL)-2-PYRROLIDINONERelated Search:

(R)-5-BROMOMETHYL-2-PYRROLIDINONE Pyrrolidine, 2-(bromomethyl)- (S)-5-(BROMOMETHYL)-2-PYRROLIDINONE

(S)-5-(BROMOMETHYL)-2-PYRROLIDINONE

(S)-5-(BROMOMETHYL)-2-PYRROLIDONE

(S)-5-BROMOMETHYL-2-OXOPYRROLIDINE

2-Pyrrolidinone,5-(bromomethyl)-,(5S)-(9CI)

2-Pyrrolidinone, 5-(bromomethyl)-, (5S)-

(5S)-5β-(Bromomethyl)pyrrolidine-2-one

[S,(-)]-5β-(Bromomethyl)pyrrolidine-2-one

5β-(Bromomethyl)pyrrolidine-2-one

(5S)-5-(broMoMethyl)pyrrolidin-2-one

(S)-5-(broMoMethyl)pyrrolidin-2-one

(5S)-5-(bromomethyl)-2-pyrrolidinone

(S)-5-(BromomethyL

(<i>S</i>)-5-(Bromomethyl)-2-pyrrolidinone

(5S)-5-(Brommethyl)pyrrolidin-2-on

72479-05-1

C5H8BrNO

HALOMETYL

pharmacetical