Methyl 2-(hydroxymethyl)nicotinate

Product Name: Methyl 2-(hydroxymethyl)nicotinate
CAS No.: 1697289-97-6
Chemical Name: Methyl 2-(hydroxymethyl)nicotinate
Synonyms: Methyl 2-(hydroxymethyl)nicotinate;2-Hydroxymethyl-nicotinic acid methyl ester;3-Pyridinecarboxylic acid, 2-(hydroxymethyl)-, methyl ester
CBNumber: CB63132483
Molecular Formula: C8H9NO3
Formula Weight: 167.16
MOL File: 1697289-97-6.mol

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Methyl 2-(hydroxymethyl)nicotinate Property

Boiling point:: 300.6±32.0 °C(Predicted)
Density: 1.244±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 12.96±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Crysdot

Product number: CD11239642
Product name: Methyl2-(hydroxymethyl)nicotinate
Purity: 97%
Packaging: 5g
Price: $465
Updated: 2021/12/16

Crysdot

Product number: CD11239642
Product name: Methyl2-(hydroxymethyl)nicotinate
Purity: 97%
Packaging: 10g
Price: $700
Updated: 2021/12/16

Alichem

Product number: 1697289976
Product name: Methyl2-(hydroxymethyl)nicotinate
Packaging: 5g
Price: $710.2
Updated: 2021/12/16

Alichem

Product number: 1697289976
Product name: Methyl2-(hydroxymethyl)nicotinate
Packaging: 10g
Price: $974.85
Updated: 2021/12/16

Crysdot

Product number: CD11239642
Product name: Methyl2-(hydroxymethyl)nicotinate
Purity: 97%
Packaging: 25g
Price: $1126
Updated: 2021/12/16

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Methyl 2-(hydroxymethyl)nicotinate Chemical Properties,Usage,Production

Uses

Methyl 2-(hydroxymethyl)nicotinate can be used as pharmaceutical intermediate for laboratory research.

Description

Methyl 2-(hydroxymethyl)nicotinate is a derivative of methyl nicotinate, which is used in the preparation of a novel glycosidase inhibitor, 1-azasugars. Methyl 2-(hydroxymethyl)nicotinate and its derivatives are used in the preparation of haemoglobin modulators^[1].

Synthesis

To a solution of methyl 2-(acetoxymethyl)nicotinate (7.90 g, 37.76 mmol, 1.0 equiv), in MeOH (80 mL) was added acetyl chloride (3.60 g, 45.86 mmol, 1.2 equiv). The reaction solution was stirred overnight at room temperature; then, the solvent was removed under reduced pressure, and the resulting residue was dissolved in water (20 mL). The pH was adjusted to 8 with NaHCO 3 solid and extracted with ethyl acetate (30 mL*3). The combined organic phase was dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated in vacuum. The residue was puri - fied by silica gel column with ethyl acetate/petroleum ether (1/1), giving Methyl 2-(hydroxymethyl)nicotinate. LCMS (ES) [M+1] + m/z: 168.

References

[1] GUOHUA ZHAO; Bruce G; Urmila C Deo. Selective Fowler Reductions: Asymmetric Total Syntheses of Isofagomine and Other 1-Azasugars from Methyl Nicotinate[J]. Organic Letters, 2000. DOI:10.1021/ol006810x.

Methyl 2-(hydroxymethyl)nicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 2-(hydroxymethyl)nicotinate Suppliers

China 11 United States 2 Global 13

Cochemical Ltd.

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ROSEWA HOLDING GROUP CO.,LIMITED

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Shanghai Haohong Pharmaceutical Co., Ltd.

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Cochemical Co. Ltd.

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Jilin Chinese Academy of Sciences-yanshen Technology

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RosewaHK Holding Group Co., Ltd.

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1697289-97-6, Methyl 2-(hydroxymethyl)nicotinateRelated Search:

Methyl 2-(hydroxymethyl)nicotinate

2-Hydroxymethyl-nicotinic acid methyl ester

3-Pyridinecarboxylic acid, 2-(hydroxymethyl)-, methyl ester

1697289-97-6