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Pemafibrate

Product Name
Pemafibrate
CAS No.
848259-27-8
Chemical Name
Pemafibrate
Synonyms
K-877;K877;CS-2768;Pemabet;Pemabert;(R)-K 13675;Pemafibrate;Pemafibrate CAS;Pemafibrate [(R)-K-13675;Pemafibrate, 10 mM in DMSO
CBNumber
CB63137695
Molecular Formula
C28H30N2O6
Formula Weight
490.55
MOL File
848259-27-8.mol
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Pemafibrate Property

Melting point:
98-99 °C(Solv: ethyl acetate (141-78-6); heptane (142-82-5))
Boiling point:
676.7±65.0 °C(Predicted)
Density 
1.250±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
3.23±0.10(Predicted)
color 
White to Off-White
InChIKey
ZHKNLJLMDFQVHJ-RUZDIDTESA-N
SMILES
C(O)(=O)[C@H](OC1=CC=CC(CN(C2=NC3=CC=CC=C3O2)CCCOC2=CC=C(OC)C=C2)=C1)CC
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
P218710
Product name
Pemafibrate
Packaging
0.5mg
Price
$220
Updated
2021/12/16
DC Chemicals
Product number
DC11360
Product name
Pemafibrate
Purity
>98%
Packaging
250mg
Price
$1500
Updated
2021/12/16
DC Chemicals
Product number
DC11360
Product name
Pemafibrate
Purity
>98%
Packaging
1g
Price
$3000
Updated
2021/12/16
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Pemafibrate Chemical Properties,Usage,Production

Uses

Pemafibrate is used in the treatment of hyperlipidemia. It also functions as a promising selective PPAR-α modulator for treatment of combined dyslipidemia phase 2 clinical trials with K-877.

in vivo

Pemafibrate (3 mg/kg, p.o.) increases plasma h-apoA-I in human apoA-I (h-apoA-I) transgenic mice, and shows higher levels of plasma h-apoA-I than fenofibrate at 300 mg/kg[1]. Pemafibrate (0.03?mg/kg) decreases levels of triglycerides and aspartate aminotransferase (AST) in PEMA-L (db/db) mice. Pemafibrate (0.1?mg/kg) not only shows such effects but increases liver weight in PEMA-H (db/db) mice. Pemafibrate enhances the pathogenesis in a rodent model of nonalcoholic steatohepatitis (NASH). Pemafibrate significantlly reduces the grade of hepatocyte ballooning in PEMA-H mice. Furthermore, Pemafibrate modulates lipid turnover and induces uncoupling protein 3 (UCP 3) expression in the liver[2]. Pemafibrate (K-877, 0.0005%) contained in high-fat diet (HFD) inhibits the body weight gain in mice. Pemafibrate significantly decreases the abundance of triglyceride (TG)-rich lipoproteins, including remnants, in postprandial plasma of mice. Pemafibrate also decreases intestinal mRNA expression of ApoB and Npc1l1[3].

IC 50

h-PPARα: 1 nM (EC50); h-PPARγ: 1.1 μM (EC50); PPARδ: 1.58 μM (EC50)

Pemafibrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Pemafibrate Suppliers

China 126 India 5 United States 7 Global 138
FarmaSino Pharmaceuticals (Jiangsu) Co.,Ltd
Tel
25-8690-7345 18651693585
Email
zfx@farmasino.com
Country
China
ProdList
136
Advantage
58
Changzhou SYM Tech. Co.,Ltd.
Tel
519-88712001 17327200503
Email
symtech@cnsymtech.com
Country
China
ProdList
38
Advantage
58
Chengdu Sino-Strong Pharmaceutical Co.,Ltd.
Tel
0086-28-68252565 13808081195
Fax
028-82783880
Email
2668085633@qq.com
Country
China
ProdList
212
Advantage
60
Nanjing Yikangda Pharmaceutical Technology Co.LTD
Tel
18118984557; 18118984557
Email
753016615@qq.com
Country
China
ProdList
497
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1077
Advantage
64
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9637
Advantage
58
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View Lastest Price from Pemafibrate manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
Pemafibrate 848259-27-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-05

848259-27-8, PemafibrateRelated Search:


  • Pemafibrate
  • K877
  • K-877
  • (R)-K 13675
  • PEMAFIBRATE;K-877;(R)-K 13675
  • CS-2768
  • Butanoic acid, 2-[3-[[2-benzoxazolyl[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]-, (2R)-
  • Pemafibrate [(R)-K-13675
  • (2R)-2-[3-[[1,3-benzoxazol-2-yl-[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]butanoic acid
  • (R)-2-(3-((Benzo[d]oxazol-2-yl(3-(4-methoxyphenoxy)propyl)amino)methyl)phenoxy)butanoic acid
  • Pemafibrate CAS
  • Pemafibrate, 10 mM in DMSO
  • Pemabert
  • Pemabet
  • 848259-27-8
  • 48259-27-8