2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

Product Name: 2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
CAS No.: 344-72-9
Chemical Name: 2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
Synonyms: NSC 4465;AKOS B029496;BUTTPARK 11\03-53;TIMTEC-BB SBB005528;Ethyl 2-amino-4-(trifluoromethyl);Ethyl-2-amino-4-trifluoromethylthiazolecarboxylate;2-AMINO-4-(TRIFLUOROMETHYL)-5-(CARBETHOXY)THIAZOLE;ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)-5-THIAZOLECARBOXY;ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)THIAXOLE-5-CARBOXYLATE;ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)-5-THIAZOLECARBOXYLATE
CBNumber: CB6313861
Molecular Formula: C7H7F3N2O2S
Formula Weight: 240.2
MOL File: 344-72-9.mol

More

Less

2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Property

Melting point:: 170 °C
Boiling point:: 81.4°C (rough estimate)
Density: 1.479
storage temp.: 2-8°C, protect from light
pka: 0.08±0.10(Predicted)
Appearance: White to light yellow Solid
CAS DataBase Reference: 344-72-9(CAS DataBase Reference)
EPA Substance Registry System: 5-Thiazolecarboxylic acid, 2-amino-4-(trifluoromethyl)-, ethyl ester (344-72-9)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 2934100090
Toxicity: LDLo ivn-mus: 75 mg/kg CBCCT* 6,142,54

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: E899688
Product name: Ethyl2-amino-4-(trifluoromethyl)thiazole-5-carboxylate
Packaging: 1g
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-0037014
Product name: 2-Amino-4-(trifluoromethyl)-5-(carbethoxy)thiazole
Packaging: 10g
Price: $90
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: COR0003892
Product name: ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE
Purity: 95.00%
Packaging: 5G
Price: $750
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: COR0003892
Product name: ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE
Purity: 95.00%
Packaging: 250MG
Price: $450
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: COR0003892
Product name: ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE
Purity: 95.00%
Packaging: 1G
Price: $470
Updated: 2021/12/16

More

Less

2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 28, p. 907, 1991 DOI: 10.1002/jhet.5570280412

Safety Profile

Poison by intravenous route.When heated to decomposition it emits toxic vapors ofNOx and SOx.

Synthesis

363-58-6

17356-08-0

344-72-9

Step 1: Synthesis of ethyl 2-amino-4-trifluoromethylthiazole-5-carboxylate (A-31) To an ethanol (200 mL) suspension of thiourea (3.3 g, 22.88 mmol) was added ethyl 2-chloro-4,4,4-trifluoroacetoacetate (5 g, 22.88 mmol), and the resulting reaction mixture was heated at 80 °C for 24 hours. Subsequently, the reaction mixture was cooled to room temperature and concentrated under vacuum. The crude product was purified by column chromatography to afford ethyl 2-amino-4-trifluoromethylthiazole-5-carboxylate (A-31) as a colorless oil (5.98 g, 85% yield). 1H NMR (500 MHz, CDCl3) δ 4.32 (q, 2H, J = 7.0 Hz), 3.56 (m, 4H), 1.70 (m, 6H), 1.36 (t, 3H, J = 7.0 Hz); LCMS (ESI) [M + 1]+ 309.3.

References

[1] Journal of Heterocyclic Chemistry, 2017, vol. 54, # 6, p. 3395 - 3402
[2] Journal of Heterocyclic Chemistry, 2017, vol. 54, # 2, p. 1625 - 1629
[3] Patent: WO2010/59606, 2010, A2. Location in patent: Page/Page column 169
[4] Tetrahedron Letters, 2005, vol. 46, # 13, p. 2251 - 2252
[5] Patent: US2004/138268, 2004, A1. Location in patent: Page/Page column 15

2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Suppliers

China 82 France 1 Germany 6 India 3 Japan 1 United Kingdom 11 United States 22 Global 126

Clearsynth Labs Limited

Tel: +91-22-26355700
Fax: +91-22-26355701
Email: info@clearsynth.com
Country: India
ProdList: 9679
Advantage: 58

A.J Chemicals

Tel: --
Fax: --
Email: sales@ajchem.in
Country: India
ProdList: 6100
Advantage: 58

Dr. Jagath Reddy's Heterocyclics

Tel: --
Fax: --
Email: jagathreddy@usa.net
Country: India
ProdList: 3886
Advantage: 42

More

Less

View Lastest Price from 2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE 344-72-9
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Career Henan Chemical Co

Product: 2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 344-72-9
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-31

344-72-9, 2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTERRelated Search:

2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Ethyl 2-pyrrolidin-1-yl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate 2-ALLYLAMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 2-AMINO-4-(TRIFLUOROMETHYL)THIAZOLE-5-C& 2-CYCLOPENTYLAMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER AKOS B029500 2-CYCLOPROPYLAMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER ETHYL 2-MORPHOLINO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE 2-PHENYLAMINO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER AKOS B029504 AKOS B029497 AKOS B029553 2-ISOPROPYLAMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 2-SEC-BUTYLAMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Ethyl 2-piperidin-1-yl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate AKOS B029499 ETHYL 2-DIMETHYLAMINO-4-TRIFLUOROMETHYL-5-THIAZOLECARBOXYLATE AKOS B029498

Ethyl-2-amino-4-trifluoromethylthiazolecarboxylate

5-Thiazolecarboxylicacid, 2-aMino-4-(trifluoroMethyl)-, ethyl ester

NSC 4465

Ethyl 2-amino-4-(trifluoromethyl)

JR-6609, Ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate, 97%

2-amino-4-(trifluoromethyl)-5-thiazolecarboxylicacidethylester

2-amino-4-(trifluoromethyl)-5-thiazolecarboxylicaciethylester

BUTTPARK 11\03-53

ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE

ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)-5-THIAZOLECARBOXYLATE

ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)THIAXOLE-5-CARBOXYLATE

ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE

AKOS B029496

2-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

2-AMINO-4-(TRIFLUOROMETHYL)-5-(CARBETHOXY)THIAZOLE

TIMTEC-BB SBB005528

Ethyl 2-amino-4-(trifluoromethyl)-5-thiazolecarboxylate 97%

Ethyl2-amino-4-(trifluoromethyl)-5-thiazolecarboxylate97%

ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)-5-THIAZOLECARBOXY

Ethyl 2-amino-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate 97%

6-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidine-3-carboxylic acid methyl ester

-AMINO-4-TRIFLUOROMETHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

5-Thiazolecarboxylic acid, 2-amino-4-(trifluoromethyl)-, ethyl ester (6CI, 8CI, 9CI, ACI)

2-amino-4-(trifluoromethyl)-5-Thiazolecarboxylic acid ethyl ester (6CI 8CI 9CI ACI)

Ethyl 2-amino-4-(trifluoromethyl)-thiazol-5-carboxylate

344-72-9

C7H7F3N2O2S

Amines

blocks

Carboxes

FluoroCompounds

Oxazoles