(4-(2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamido)-2-oxo-1l4,2l5-pyridin-1-yl)methyldihydrogenphosphate

Product Name: (4-(2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamido)-2-oxo-1l4,2l5-pyridin-1-yl)methyldihydrogenphosphate
CAS No.: 1793080-72-4
Chemical Name: (4-(2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamido)-2-oxo-1l4,2l5-pyridin-1-yl)methyldihydrogenphosphate
Synonyms: VX-150;EOS-62073;Sorafenib Impurity 86;VX-150, 10 mM in DMSO;Pramipexole Impurity 66-d5 Dihydrochloride;Na+ channels,VX-150,indications,Inhibitor,Na channels,orally,inhibit,pain,VX 150,VX150,Sodium Channel;(4-(2-(4-fluoro-2-methylphenoxy) -4-(trifluoromethyl)benzamido) -2-oxopyridin-1(2H)-yl)methyl dihydrogen phosphate;(4-(2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamido)-2-oxo-1l4,2l5-pyridin-1-yl)methyldihydrogenphosphate;Benzamide, N-[1,2-dihydro-2-oxo-1-[(phosphonooxy)methyl]-4-pyridinyl]-2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)-
CBNumber: CB63142264
Molecular Formula: C21H17F4N2O7P
Formula Weight: 516.34
MOL File: 1793080-72-4.mol

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(4-(2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamido)-2-oxo-1l4,2l5-pyridin-1-yl)methyldihydrogenphosphate Property

Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (242.09 mM; Need ultrasonic)
form: Solid
pka: 1.72±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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(4-(2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamido)-2-oxo-1l4,2l5-pyridin-1-yl)methyldihydrogenphosphate Chemical Properties,Usage,Production

Uses

VX-150 is an orally active, highly selective NaV1.8 inhibitor. VX-150 has the potential for various pain indications research[1].

IC 50

Na_v1.8

References

[1] Hemme J Hijma, et al. A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults. Pain Med. 2021 Aug 6;22(8):1814-1826. DOI:10.1093/pm/pnab032

(4-(2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamido)-2-oxo-1l4,2l5-pyridin-1-yl)methyldihydrogenphosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-(2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamido)-2-oxo-1l4,2l5-pyridin-1-yl)methyldihydrogenphosphate Suppliers

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1793080-72-4, (4-(2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamido)-2-oxo-1l4,2l5-pyridin-1-yl)methyldihydrogenphosphateRelated Search:

(4-(2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamido)-2-oxo-1l4,2l5-pyridin-1-yl)methyldihydrogenphosphate

EOS-62073

(4-(2-(4-fluoro-2-methylphenoxy) -4-(trifluoromethyl)benzamido) -2-oxopyridin-1(2H)-yl)methyl dihydrogen phosphate

VX-150

Benzamide, N-[1,2-dihydro-2-oxo-1-[(phosphonooxy)methyl]-4-pyridinyl]-2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)-

Na+ channels,VX-150,indications,Inhibitor,Na channels,orally,inhibit,pain,VX 150,VX150,Sodium Channel

Sorafenib Impurity 86

Pramipexole Impurity 66-d5 Dihydrochloride

VX-150, 10 mM in DMSO

1793080-72-4

C21H17F4N2O7P