ChemicalBook > CAS DataBase List > SMURF1 inhibitor A01

SMURF1 inhibitor A01

Product Name: SMURF1 inhibitor A01
CAS No.: 1007647-73-5
Chemical Name: SMURF1 inhibitor A01
Synonyms: A01;Smurf1-IN-A01;SMURF1 inhibitor A01;A01 (Smurf1 inhibitor);SMURF1 inhibitor A01 - A01;Smurf1-IN-A01, 10 mM in DMSO;A01 (Smurf1 inhibitor) >=98% (HPLC);Inhibitor,Smurf1 IN A01,inhibit,Smurf1INA01,A-01,Smurf-1-IN-A01,A 01;(4-((4-Chloro-3-(trifluoromethyl)phenyl)sulfonyl)piperazin-1-yl)(4-(5-methyl-1H-pyrazol-1-yl)phenyl)methanone;[4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone
CBNumber: CB63146383
Molecular Formula: C22H20ClF3N4O3S
Formula Weight: 512.93
MOL File: 1007647-73-5.mol

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SMURF1 inhibitor A01 Property

Boiling point:: 642.3±65.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO : 62.5 mg/mL (121.85 mM; Need ultrasonic)
form: A crystalline solid
pka: 0.80±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1404
Product name: A01 (Smurf1 inhibitor)
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $118
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1404
Product name: A01 (Smurf1 inhibitor)
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $475
Updated: 2025/07/31

Cayman Chemical

Product number: 26137
Product name: A01
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 26137
Product name: A01
Packaging: 50mg
Price: $577
Updated: 2024/03/01

Cayman Chemical

Product number: 26137
Product name: A01
Packaging: 10mg
Price: $175
Updated: 2024/03/01

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SMURF1 inhibitor A01 Chemical Properties,Usage,Production

Uses

A01 is a microlmolecule inhibitor of negatively regulatory factor Smurf1 for promoting bone formation.

Biological Activity

A01 is a high affinity selective inhibitor of E3 ubiquitin-protein ligase Smurf1 (Smad ubiquitination regulatory factor-1) th at disturbs Smurf1-Smad1/5 interaction and blocks Smurf1 mediated Smad1/5 ubiquitination. A01 increases responsiveness to BMP-2 in myoblasts and osteoblasts.

in vivo

Smurf1-IN-A01 (10 μM, 2 μL, Injected into vitreous cavity by micro-syringe, single dose) alleviated retinal injury in retinal degeneration model mice^[4].

Animal Model:	retinal degeneration model mice^[4]
Dosage:	10 μM ,2μL
Administration:	Injected into vitreous cavity by micro-syringe
Result:	Reduced drusen-like spots. Resulted outer nuclear layers wider and straighter. Caused inner segment and outer segment hinge of photoreceptor cells disappeared. Down-regulated NLRP3 and inhibited IL-1β. Could decrease the death in NaIO₃ retina.

IC 50

IL-1β; HSP90β; ERα

storage

Store at +4°C

SMURF1 inhibitor A01 Preparation Products And Raw materials

Raw materials

Preparation Products

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1007647-73-5, SMURF1 inhibitor A01Related Search:

SMURF1 inhibitor A01

SMURF1 inhibitor A01 - A01

Smurf1-IN-A01

A01

[4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone

Methanone, [4-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]-

A01 (Smurf1 inhibitor) >=98% (HPLC)

(4-((4-Chloro-3-(trifluoromethyl)phenyl)sulfonyl)piperazin-1-yl)(4-(5-methyl-1H-pyrazol-1-yl)phenyl)methanone

Inhibitor,Smurf1 IN A01,inhibit,Smurf1INA01,A-01,Smurf-1-IN-A01,A 01

Smurf1-IN-A01, 10 mM in DMSO

A01 (Smurf1 inhibitor)

1007647-73-5

C22H20ClF3N4O3S