ChemicalBook > CAS DataBase List > SMURF1 inhibitor A01

SMURF1 inhibitor A01

Product Name
SMURF1 inhibitor A01
CAS No.
1007647-73-5
Chemical Name
SMURF1 inhibitor A01
Synonyms
A01;Smurf1-IN-A01;SMURF1 inhibitor A01;SMURF1 inhibitor A01 - A01;Smurf1-IN-A01, 10 mM in DMSO;A01 (Smurf1 inhibitor) >=98% (HPLC);Inhibitor,Smurf1 IN A01,inhibit,Smurf1INA01,A-01,Smurf-1-IN-A01,A 01;[4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone;(4-((4-Chloro-3-(trifluoromethyl)phenyl)sulfonyl)piperazin-1-yl)(4-(5-methyl-1H-pyrazol-1-yl)phenyl)methanone;Methanone, [4-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]-
CBNumber
CB63146383
Molecular Formula
C22H20ClF3N4O3S
Formula Weight
512.93
MOL File
1007647-73-5.mol
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SMURF1 inhibitor A01 Property

Boiling point:
642.3±65.0 °C(Predicted)
Density 
1.46±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO : 62.5 mg/mL (121.85 mM; Need ultrasonic)
form 
A crystalline solid
pka
0.80±0.10(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26137
Product name
A01
Packaging
5mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
26137
Product name
A01
Packaging
50mg
Price
$577
Updated
2024/03/01
Cayman Chemical
Product number
26137
Product name
A01
Packaging
10mg
Price
$175
Updated
2024/03/01
Cayman Chemical
Product number
26137
Product name
A01
Packaging
25mg
Price
$360
Updated
2024/03/01
Tocris
Product number
5397
Product name
A01
Purity
≥98%(HPLC)
Packaging
10
Price
$168
Updated
2021/12/16
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SMURF1 inhibitor A01 Chemical Properties,Usage,Production

Uses

A01 is a microlmolecule inhibitor of negatively regulatory factor Smurf1 for promoting bone formation.

Biological Activity

A01 is a high affinity selective inhibitor of E3 ubiquitin-protein ligase Smurf1 (Smad ubiquitination regulatory factor-1) th at disturbs Smurf1-Smad1/5 interaction and blocks Smurf1 mediated Smad1/5 ubiquitination. A01 increases responsiveness to BMP-2 in myoblasts and osteoblasts.

storage

Store at +4°C

SMURF1 inhibitor A01 Preparation Products And Raw materials

Raw materials

Preparation Products

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SMURF1 inhibitor A01 Suppliers

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1007647-73-5, SMURF1 inhibitor A01Related Search:


  • SMURF1 inhibitor A01
  • SMURF1 inhibitor A01 - A01
  • Smurf1-IN-A01
  • A01
  • [4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone
  • Methanone, [4-[[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]-
  • A01 (Smurf1 inhibitor) >=98% (HPLC)
  • (4-((4-Chloro-3-(trifluoromethyl)phenyl)sulfonyl)piperazin-1-yl)(4-(5-methyl-1H-pyrazol-1-yl)phenyl)methanone
  • Inhibitor,Smurf1 IN A01,inhibit,Smurf1INA01,A-01,Smurf-1-IN-A01,A 01
  • Smurf1-IN-A01, 10 mM in DMSO
  • 1007647-73-5
  • C22H20ClF3N4O3S