XE 991 dihydrochloride

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XE 991 dihydrochloride

Product Name: XE 991 dihydrochloride
CAS No.: 122955-13-9
Chemical Name: XE 991 dihydrochloride
Synonyms: XE 991 HCl;XE991 HCl (LS190926);XE 991 (hydrochloride);10,10-bis(pyridin-4-ylmethyl)anthracen-9-one;10,10-bis(pyridin-4-ylmethyl)anthracen-9-one:dihydrochloride;10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride;XE991,inhibit,XE 991 dihydrochloride,KcsA,XE 991,XE-991,Inhibitor,Potassium Channel
CBNumber: CB63146404
Molecular Formula: C26H21ClN2O
Formula Weight: 412.92
MOL File: 122955-13-9.mol

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XE 991 dihydrochloride Property

storage temp.: Store at -20°C
solubility: DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 2 mg/mL
form: Powder
color: Off-white to light yellow
Water Solubility: Soluble to 100 mM in water

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 14582
Product name: XE 991 (hydrochloride)
Purity: ≥99%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 14582
Product name: XE 991 (hydrochloride)
Purity: ≥99%
Packaging: 10mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 14582
Product name: XE 991 (hydrochloride)
Purity: ≥99%
Packaging: 50mg
Price: $477
Updated: 2024/03/01

TRC

Product number: X750935
Product name: XE991Dihydrochloride
Packaging: 100mg
Price: $625
Updated: 2021/12/16

ChemScene

Product number: CS-0029210
Product name: XE991dihydrochloride
Purity: 98.44%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

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XE 991 dihydrochloride Chemical Properties,Usage,Production

Description

The KCNQ potassium channels are neuronal modulators which combine with other KQT or KCNE channels to form heteromultimers. XE 991 is a blocker of KCNQ channels that potently inhibits KCNQ1 and 2 homomeric channels (IC₅₀ = 0.75 and 0.71 μM, respectively) as well as KCNQ2+3 heteromultimers (IC₅₀ = 0.6 μM). It much less effectively blocks eag, erg, and elk channels. The effectiveness of XE 991 against KCNQ channels depends on partners or accessory proteins. Through these actions, XE 991 enhances acetylcholine release from rat brain slices (EC₅₀ = 490 nM) and shows good in vivo potency and duration of action, suggesting utility in Alzheimer’s disease therapeutics. While early studies focused on actions in the central nervous system, XE 991 can be used to explore the roles of KCNQ channels in neuronal regulation throughout the body.

Uses

XE 991 dihydrochloride is a potent & selective inhibitor of KCNQ voltage-gated K-channels.

storage

Desiccate at RT

XE 991 dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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XE 991 dihydrochloride Suppliers

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122955-13-9, XE 991 dihydrochlorideRelated Search:

XEN445

XE 991 (hydrochloride)

10,10-bis(pyridin-4-ylmethyl)anthracen-9-one:dihydrochloride

10,10-bis(pyridin-4-ylmethyl)anthracen-9-one

XE991 HCl (LS190926)

XE991,inhibit,XE 991 dihydrochloride,KcsA,XE 991,XE-991,Inhibitor,Potassium Channel

XE 991 HCl

10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride

122955-13-9