ChemicalBook > CAS DataBase List > XE 991 dihydrochloride

XE 991 dihydrochloride

Product Name: XE 991 dihydrochloride
CAS No.: 122955-13-9
Chemical Name: XE 991 dihydrochloride
Synonyms: XE 991 HCl;blocks M current;XE991 HCl (LS190926);XE 991 (hydrochloride);XE991 dihydrochloride ，S2967;XE 991 dihydrochloride, 10 mM in DMSO;XE-991 dihydrochloride，KCNQ channel blocker;XE-991 dihydrochloride, KCNQ channel blocker;10,10-bis(pyridin-4-ylmethyl)anthracen-9-one;10,10-bis(pyridin-4-ylmethyl)anthracen-9-one:dihydrochloride
CBNumber: CB63146404
Molecular Formula: C26H21ClN2O
Formula Weight: 412.92
MOL File: 122955-13-9.mol

Less

XE 991 dihydrochloride Property

storage temp.: Store at -20°C
solubility: DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 2 mg/mL
form: Powder
color: Off-white to light yellow
Water Solubility: Soluble to 100 mM in water

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 14582
Product name: XE 991 (hydrochloride)
Purity: ≥99%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 14582
Product name: XE 991 (hydrochloride)
Purity: ≥99%
Packaging: 10mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 14582
Product name: XE 991 (hydrochloride)
Purity: ≥99%
Packaging: 50mg
Price: $477
Updated: 2024/03/01

TRC

Product number: X750935
Product name: XE991Dihydrochloride
Packaging: 100mg
Price: $625
Updated: 2021/12/16

ChemScene

Product number: CS-0029210
Product name: XE991dihydrochloride
Purity: 98.44%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

Less

XE 991 dihydrochloride Chemical Properties,Usage,Production

Description

The KCNQ potassium channels are neuronal modulators which combine with other KQT or KCNE channels to form heteromultimers. XE 991 is a blocker of KCNQ channels that potently inhibits KCNQ1 and 2 homomeric channels (IC₅₀ = 0.75 and 0.71 μM, respectively) as well as KCNQ2+3 heteromultimers (IC₅₀ = 0.6 μM). It much less effectively blocks eag, erg, and elk channels. The effectiveness of XE 991 against KCNQ channels depends on partners or accessory proteins. Through these actions, XE 991 enhances acetylcholine release from rat brain slices (EC₅₀ = 490 nM) and shows good in vivo potency and duration of action, suggesting utility in Alzheimer’s disease therapeutics. While early studies focused on actions in the central nervous system, XE 991 can be used to explore the roles of KCNQ channels in neuronal regulation throughout the body.

Uses

XE 991 dihydrochloride is a potent & selective inhibitor of KCNQ voltage-gated K-channels.

storage

Desiccate at RT

References

[1] H S WANG. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.[J]. Science, 1998, 282 5395: 1890-1893. DOI: 10.1126/science.282.5395.1890
[2] H S WANG. Molecular basis for differential sensitivity of KCNQ and I(Ks) channels to the cognitive enhancer XE991.[J]. Molecular Pharmacology, 2000, 57 6: 1218-1223.
[3] R ZACZEK. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine.[J]. Journal of Pharmacology and Experimental Therapeutics, 1998, 285 2: 724-730.
[4] JOANNA M HAWRYLUK. KCNQ channels determine serotonergic modulation of ventral surface chemoreceptors and respiratory drive.[J]. Journal of Neuroscience, 2012, 32 47: 16943-16952. DOI: 10.1523/jneurosci.3043-12.2012

XE 991 dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Less

XE 991 dihydrochloride Suppliers

China 56 United Kingdom 1 United States 7 USA 1 Global 65

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4768
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 10410
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

Henan Weituxi Chemical Technology Co., Ltd.

Tel: 0371-63284658 18135795563
Fax: QQ:2885349392
Email: 2885349392@qq.com
Country: China
ProdList: 9992
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

cjbscvictory

Tel: 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10503
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4810
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Suzhou Zhixin Biotechnology Co., Ltd.

Tel: 0512-65118909 18100677375
Email: sales@szzxbio.com
Country: China
ProdList: 2993
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Shanghai Jieshikai Biotechnology Co. , Ltd.

Tel: 021-57520305 13795461237
Email: zhuruyan@jskchem.com
Country: China
ProdList: 49234
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

Hunan Hui Bai Yi New Materials Co., Ltd

Tel: 0745-2866551 19976851779
Email: 3002713163@qq.com
Country: China
ProdList: 7333
Advantage: 58

R&D Systems, Inc

Tel: 18003437475
Fax: 1-612-656-4400
Email: rdname@qq.com
Country: China
ProdList: 6960
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Changzhou Xianglong Pharmaceutical Technology Co., Ltd.,

Tel: 18915873328 18915873328
Email: 296197970@qq.com
Country: China
ProdList: 11051
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Adooq Bioscience LLC

Tel: 400-025-6535
Email: sales@adooq.cn
Country: China
ProdList: 6215
Advantage: 58

Selleck Chemicals

Tel: 400-668-6834
Email: info@selleck.cn
Country: China
ProdList: 6071
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 33024
Advantage: 60

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

Shanghai Qimin Biotechnology Co., Ltd.

Tel: 13032137268
Email: 171198252@qq.com
Country: China
ProdList: 130
Advantage: 58

Guangzhou Bingheng Biotechnology Co., Ltd.

Tel: 13631342304
Country: CHINA
ProdList: 188
Advantage: 58

Shenzhen Campbell Biotechnology Co., Ltd.

Tel: 18028747627
Country: CHINA
ProdList: 191
Advantage: 58

Guangdong Liusheng Trading Co., Ltd.

Tel: 13676271149
Country: CHINA
ProdList: 183
Advantage: 58

Guangzhou Keyu Biotechnology Co., Ltd.

Tel: 18818657868
Country: CHINA
ProdList: 0
Advantage: 58

Foshan Minghua Biotechnology Co., Ltd.

Tel: 18312287787
Country: CHINA
ProdList: 196
Advantage: 58

Guangzhou Kegou Biotechnology Co., Ltd.

Tel: 18689410811
Country: CHINA
ProdList: 178
Advantage: 58

Guangzhou Jingyan Biotechnology Co., Ltd.

Tel: 13822277471
Country: CHINA
ProdList: 187
Advantage: 58

Aoki Biotechnology (Shenzhen) Co., Ltd.

Tel: 18566777408
Country: CHINA
ProdList: 156
Advantage: 58

Guangzhou Zhuanyan Biotechnology Co., Ltd.

Tel: 18926165828
Country: CHINA
ProdList: 198
Advantage: 58

Biorbyt Ltd.

Tel: --
Fax: --
Email: info@biorbyt.com
Country: CHINA
ProdList: 6482
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

Beijing Fubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: info@f-biology.com
Country: CHINA
ProdList: 6170
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: market@xlswkj.com
Country: CHINA
ProdList: 6793
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Shanghai Haoran Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 470003480@QQ.COM
Country: CHINA
ProdList: 6955
Advantage: 58

Beijing Dongge Boye Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1861586486@qq.com
Country: CHINA
ProdList: 6648
Advantage: 58

Shanghai Yaoyun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 912529879@qq.com
Country: CHINA
ProdList: 6448
Advantage: 58

122955-13-9, XE 991 dihydrochlorideRelated Search:

XEN445 10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE

XE 991 (hydrochloride)

10,10-bis(pyridin-4-ylmethyl)anthracen-9-one:dihydrochloride

10,10-bis(pyridin-4-ylmethyl)anthracen-9-one

XE991 HCl (LS190926)

XE991,inhibit,XE 991 dihydrochloride,KcsA,XE 991,XE-991,Inhibitor,Potassium Channel

XE 991 HCl

10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride

blocks M current

XE-991 dihydrochloride, KCNQ channel blocker

XE-991 dihydrochloride，KCNQ channel blocker

XE 991 dihydrochloride, 10 mM in DMSO

XE991 dihydrochloride ，S2967

122955-13-9