CPHPC

Product Name: CPHPC
CAS No.: 224624-80-0
Chemical Name: CPHPC
Synonyms: CPHPC;CPOHPC;Ro63-8695;Miridesap;GSK2315698;CPOHPC acid;CPHPC(Miridesap);CPHPC, Ro-63-8695;CPOHPC （acid form;GSK2315698,Miridesap
CBNumber: CB63147209
Molecular Formula: C16H24N2O6
Formula Weight: 340.37
MOL File: 224624-80-0.mol

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CPHPC Property

storage temp.: 2-8°C
solubility: ≤30mg/ml in ethanol;20mg/ml in DMSO;25mg/ml in dimethyl formamide
form: crystalline solid
color: White to off-white

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 75500
Product name: CPHPC
Purity: ≥95%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 75500
Product name: CPHPC
Purity: ≥95%
Packaging: 10mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 75500
Product name: CPHPC
Purity: ≥95%
Packaging: 50mg
Price: $477
Updated: 2024/03/01

TRC

Product number: M364935
Product name: Miridesap
Packaging: 5g
Price: $1890
Updated: 2021/12/16

ApexBio Technology

Product number: C3597
Product name: CPHPC
Packaging: 10mg
Price: $129
Updated: 2021/12/16

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CPHPC Chemical Properties,Usage,Production

Description

Serum amyloid P (SAP) is pentraxin with roles in inflammation and immune response. CPHPC is a divalent crosslinker of SAP that causes rapid depletion of circulating SAP via hepatic clearance. It also produces significant reduction of SAP from cerebrospinal fluid and visceral amyloid deposits. CPHPC has been used with anti-SAP antibodies to eliminate amyloid deposits in clinical trials of systemic amyloidosis.

Uses

Miridesap is a potential drug in the treatment of amyloidosis.

in vitro

previous study found that the multi-point binding of cphpc between pairs of pentameric sap molecules increased the avidity of the interaction, and this was reflected in an apparent affinity constant of 10 nm. moreover, the x-ray crystal structure of the sap–cphpc complex confirmed that it was a decamer composed of two pentameric sap molecules reversibly crosslinked by five cphpc molecules [1].

in vivo

mice were received cphpc at 1 mg/ml in their drinking water for the rest of the experiment. circulating human sap was depleted but significant amounts of sap remained in the amyloid deposits. five days after starting on cphpc, one group received a single intraperitoneal injection of 50 mg of the igg fraction of sheep anti-human sap antiserum, containing 7 mg of anti-sap antibody. a control group received 50 mg of unrelated sheep igg. the third group received no treatment and thus controlled for spontaneous regression of aa amyloid. results showed that there was dramatically less amyloid after treatment with cphpc plus anti-sap antibody than in the other two groups but there was no difference between cphpc alone and no treatment [2].

References

[1] m. b. pepys, j. herbert, w. l. hutchinson, et al. targeted pharmacological depletion of serum amyloid p component for treatment of human amyloidosis. nature 417, 254-259 (2002).
[2] k. bodin, s. ellmerich, m. c. kahan, et al. antibodies to human serum amyloid p component eliminate visceral amyloid deposits. nature 468, 93-97 (2010).
[3] gillmore jd et al. ustained pharmacological depletion of serum amyloid p component in patients with systemic amyloidosis. br j haematol. 2010 mar;148(5):760-7.

CPHPC Preparation Products And Raw materials

Raw materials

Preparation Products

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CPHPC Suppliers

China 35 United States 8 Global 43

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai SuperLan Chemcial Technique Centre

Tel: 021-2022843681 15618226720
Fax: +86-21-51601218
Email: lucy@atkchemical.com
Country: China
ProdList: 9952
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Dezhou LonWel Pharmaceutical Technology Co., Ltd.

Tel: 13761310616
Fax: QQ: 39324283
Email: 39324283@qq.com
Country: China
ProdList: 1991
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28806
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3254
Advantage: 58

Shanghai Moss Medicine Technology Co., Ltd.

Tel: +86-188369842 +86-15618151133
Fax: QQ188369842
Email: 188369842@qq.com
Country: China
ProdList: 1944
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30236
Advantage: 58

224624-80-0, CPHPCRelated Search:

CPHPC

CPHPC, Ro-63-8695

1,1'-(1,6-Dioxo-1,6-hexanediyl)bis[D-proline]

GSK2315698

Miridesap

Ro63-8695

GSK2315698,Miridesap

CPHPC(GSK2315698,Miridesap)

CPOHPC （acid form

CPOHPC acid

MIRIDESAP; RO-638695; RO 638695; RO638695;CPHPC;CPOHPC (ACID FORM; CPOHPC ACID

D-Proline, 1,1'-(1,6-dioxo-1,6-hexanediyl)bis-

CPHPC(Miridesap)

(2R,2'R)-1,1'-Adipoylbis(pyrrolidine-2-carboxylic acid)

GSK 2315698,GSK-2315698,Miridesap,Inhibitor,inhibit

CPOHPC

(2R,2'R)-1,1'-Adipoylbis(pyrrolidine-2-carboxylic acid)

224624-80-0