ChemicalBook > CAS DataBase List > ABX-464

ABX-464

Product Name: ABX-464
CAS No.: 1258453-75-6
Chemical Name: ABX-464
Synonyms: Obefazimod;ABX-464;SPL-464;miR-124;ABX464 ，S0076;ABX464(ABX-464;ABX464 (ABX-464,ABX 464);Obefazimod, 10 mM in DMSO;8-Chloro-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine;2-Quinolinamine, 8-chloro-N-[4-(trifluoromethoxy)phenyl]-
CBNumber: CB63151927
Molecular Formula: C16H10ClF3N2O
Formula Weight: 338.71
MOL File: 1258453-75-6.mol

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ABX-464 Property

Boiling point:: 412.3±45.0 °C(Predicted)
Density: 1.440±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 100 mg/mL (295.24 mM)
form: Solid
pka: 1.50±0.61(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0020537
Product name: ABX464
Purity: 99.98%
Packaging: 5mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-0020537
Product name: ABX464
Purity: 99.98%
Packaging: 10mg
Price: $280
Updated: 2021/12/16

ChemScene

Product number: CS-0020537
Product name: ABX464
Purity: 99.98%
Packaging: 25mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-0020537
Product name: ABX464
Purity: 99.98%
Packaging: 50mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0020537
Product name: ABX464
Purity: 99.98%
Packaging: 100mg
Price: $1150
Updated: 2021/12/16

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ABX-464 Chemical Properties,Usage,Production

Uses

Obefazimod (ABX464) is a potent anti-HIV agent. Obefazimod inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) with an IC50 ranging between 0.1 μM and 0.5 μM.

in vivo

Humanized mice reconstituted with human lymphoid cells provide rapid, reliable, reproducible experimental systems for testing the efficacy of Obefazimod in vivo. In the initial setting, SCID mice are reconstituted with PBMCs and then infected with the HIV-1 strain JR-CSF. Mice are treated twice a day (b.i.d) for 15 days by oral gavage with 20 mg/kg of Obefazimod. Measures of viral RNA show that the oral treatment with Obefazimod is able to significantly reduce the viral load over a period of 15 days of treatment. FACS analysis of blood samples show that treatment with Obefazimod prevents depletion of CD4⁺ cells following infection of reconstituted mice and thereby restores the CD8⁺/CD4⁺ ratio back to that of non-infected mice^[1].

IC 50

HIV-1: 0.1-0.5 μM (IC₅₀, in PBMCs)

storage

Store at -20°C

References

[1] Campos N, et al. Long lasting control of viral rebound with a new drug ABX464 targeting Rev-mediated viral RNA biogenesis. Retrovirology. 2015 Apr 9;12:30. DOI:10.1186/s12977-015-0159-3

ABX-464 Preparation Products And Raw materials

Raw materials

Preparation Products

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ABX-464 Suppliers

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1258453-75-6, ABX-464Related Search:

ABX-464

ABX464(ABX-464

2-Quinolinamine, 8-chloro-N-[4-(trifluoromethoxy)phenyl]-

Obefazimod

Obefazimod,HIV,Inhibitor,Human immunodeficiency virus,inhibit,ABX 464

8-Chloro-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine

ABX464 (ABX-464,ABX 464)

Obefazimod, 10 mM in DMSO

ABX464 ，S0076

miR-124

SPL-464

1258453-75-6