BB-Cl-Amidine
- Product Name
- BB-Cl-Amidine
- CAS No.
- 1802637-39-3
- Chemical Name
- BB-Cl-Amidine
- Synonyms
- CS-2826;BB-Cl-Amidine;N-{(1S)-1-(1H-Benzimidazol-2-yl)-4-[(2-chloroethanimidoyl)amino]butyl}-4-biphenylcarboxamide;(S)-N-(1-(1H-Benzo[d]imidazol-2-yl)-4-(2-chloroacetimidamido)butyl)-[1,1'-biphenyl]-4-carboxamide;Peptidylarginine Deiminase,Inhibitor,BBClAmidine,BB Cl Amidine,Protein Arginine Deiminase,inhibit;N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-4-(2-chloroethanimidamido)butyl]-[1,1'-biphenyl]-4-carboxamide;[1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-
- CBNumber
- CB63152560
- Molecular Formula
- C26H26ClN5O
- Formula Weight
- 459.971
- MOL File
- 1802637-39-3.mol
BB-Cl-Amidine Property
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO:76.33(Max Conc. mg/mL);165.94(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);43.48(Max Conc. mM)
Water:70.0(Max Conc. mg/mL);152.18(Max Conc. mM)
Ethanol:54.5(Max Conc. mg/mL);118.48(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.09(Max Conc. mM) - form
- A crystalline solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 17079
- Product name
- BB-Cl-Amidine
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 17079
- Product name
- BB-Cl-Amidine
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $302
- Updated
- 2024/03/01
- Product number
- 17079
- Product name
- BB-Cl-Amidine
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $99
- Updated
- 2021/12/16
- Product number
- 17079
- Product name
- BB-Cl-Amidine
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $169
- Updated
- 2024/03/01
- Product number
- 6591EJ
- Product name
- BB-Cl-Amidine
- Packaging
- 1mg
- Price
- $313
- Updated
- 2021/12/16
BB-Cl-Amidine Chemical Properties,Usage,Production
Description
BB-Cl-Amidine is a modified version of Cl-amidine that retains the functional components but possesses a C-terminal benzimidazole group designed to limit proteolysis of the C-terminal amide. BB-Cl-Amidine irreversibly inactivates all four PAD subtypes (kinact/KI = 16,100, 4,100, 6,800, and 13,300 M-1min-1 for PAD1-4, respectively) by covalently modifying an active site cysteine that is important for its catalytic activity. The cellular potency of BB-Cl-amidine against PAD4 is increased 20-fold over the parent compound (EC50 = 8.8 μM versus >200 μM for Cl-amidine). BB-Cl-Amidine also has a significantly longer in vivo half-life than Cl-amidine (1.75 h versus ~15 min, respectively). Both compounds inhibit the formation of neutrophil extracellular traps without altering H2O2 production by neutrophils. BB-Cl-Amidine is effective in vivo, improving endothelial function while downregulating the expression of type I interferon-regulated genes in MRL/lpr mice.
BB-Cl-Amidine Preparation Products And Raw materials
Raw materials
Preparation Products
BB-Cl-Amidine Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58