ChemicalBook > CAS DataBase List > GQ-16

GQ-16

Product Name
GQ-16
CAS No.
870554-67-9
Chemical Name
GQ-16
Synonyms
GQ-16;GQ-16 Exclusive;5Z-[(5-bromo-2-methoxyphenyl)methylene]-3-[(4-methylphenyl)methyl]-2,4-thiazolidinedione;2,4-Thiazolidinedione, 5-[(5-bromo-2-methoxyphenyl)methylene]-3-[(4-methylphenyl)methyl]-, (5Z)-;(5Z)-5-[(5-bromo-2-methoxyphenyl)methylidene]-3-[(4-methylphenyl)methyl]-1,3-thiazolidine-2,4-dione;PPAR,Inhibitor,reduced adipogenic actions,PPARγ,GQ-16,insulin sensitization,inhibit,Peroxisome proliferator-activated receptors,insulin Resistance,GQ16,GQ 16
CBNumber
CB63152621
Molecular Formula
C19H16BrNO3S
Formula Weight
418.3
MOL File
870554-67-9.mol
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GQ-16 Property

Melting point:
147 °C
Boiling point:
549.8±60.0 °C(Predicted)
Density 
1.522±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≤0.33mg/ml in DMSO;5mg/ml in dimethyl formamide
form 
crystalline solid
pka
-2.57±0.20(Predicted)
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11908
Product name
GQ-16
Purity
≥98%
Packaging
5mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
11908
Product name
GQ-16
Purity
≥98%
Packaging
10mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
11908
Product name
GQ-16
Purity
≥98%
Packaging
50mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
11908
Product name
GQ-16
Purity
≥98%
Packaging
100mg
Price
$426
Updated
2024/03/01
ApexBio Technology
Product number
C3407
Product name
GQ-16
Packaging
100mg
Price
$485
Updated
2021/12/16
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GQ-16 Chemical Properties,Usage,Production

Description

Full activation of peroxisome proliferator-activated receptor γ (PPARγ), e.g., using thiazolidinediones, effectively treats insulin resistance and type 2 diabetes but also commonly promotes weight gain, hyperphagia, and edema. GQ-16 is a partial agonist for PPARγ (Ki = 160 nM) which induces adipogenesis significantly less than the full activator rosiglitazone. Like rosiglitazone, GQ-16 reverses high fat diet-mediated impairments in insulin signaling. However, GQ-16 does not induce weight gain, hyperphagia, or edema. GQ-16 does not activate PPARα, PPARβ/δ, or RXRα.

in vitro

gq-16 was an effective inhibitor of cdk5-mediated phosphorylation of pparγ, exhibiting a ki value of 160 nm. gq-16 was specific for pparγ and possessed no detectable activity when tested for the ability to activate other ppar subtypes (pparα or pparβ/δ) or rxrα. in both nih-3t3 and c3h10t1/2 cell models with established pparγ-dependent adipogenesis, gq-16 displayed reduced the potential of adipogenic [1].

in vivo

in the mouse model of diet-induced obesity and insulin resistance, administration of gq-16 (20 mg/kg/day) by oral gavage daily blocked hfd-dependent effects on intracellular inflammatory pathways and improved insulin sensitivity. gq-16 did not elicit increased weight gain [1].

References

[1] amato a a, rajagopalan s, lin j z, et al. gq-16, a novel peroxisome proliferator-activated receptor γ (pparγ) ligand, promotes insulin sensitization without weight gain[j]. journal of biological chemistry, 2012, 287(33): 28169-28179.

GQ-16 Preparation Products And Raw materials

Raw materials

Preparation Products

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GQ-16 Suppliers

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870554-67-9, GQ-16Related Search:


  • GQ-16
  • 5Z-[(5-bromo-2-methoxyphenyl)methylene]-3-[(4-methylphenyl)methyl]-2,4-thiazolidinedione
  • (5Z)-5-[(5-bromo-2-methoxyphenyl)methylidene]-3-[(4-methylphenyl)methyl]-1,3-thiazolidine-2,4-dione
  • GQ-16 Exclusive
  • PPAR,Inhibitor,reduced adipogenic actions,PPARγ,GQ-16,insulin sensitization,inhibit,Peroxisome proliferator-activated receptors,insulin Resistance,GQ16,GQ 16
  • 2,4-Thiazolidinedione, 5-[(5-bromo-2-methoxyphenyl)methylene]-3-[(4-methylphenyl)methyl]-, (5Z)-
  • 870554-67-9