Dehydrocorydaline chloride

Product Name: Dehydrocorydaline chloride
CAS No.: 10605-03-5
Chemical Name: Dehydrocorydaline chloride
Synonyms: Dehydrocorydaline chloride;13-Methylpalmatine chloride;Dehydrocorydaline chloride, 99.95%;2,3,9,10-Tetramethoxy-13-methyl-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium chloride;inhibit,Bcl-2 Family,Dehydrocorydaline chloride,Autophagy,PARP,poly ADP ribose polymerase,Caspase,13-Methylpalmatine,Dehydrocorydaline,p38 MAPK,Parasite,Inhibitor
CBNumber: CB63152944
Molecular Formula: C22H24ClNO4
Formula Weight: 401.88326
MOL File: 10605-03-5.mol

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Dehydrocorydaline chloride Property

Melting point:: 191-193 °C (decomp)
storage temp.: Store at -20°C
solubility: DMSO: 20 mg/ml
form: A solid
color: Light yellow to yellow

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Safety

HS Code: 2933399990
Toxicity: mouse,LD50,intravenous,9500ug/kg (9.5mg/kg),United States Patent Document. Vol. #3849561,

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H316Causes mild skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6061
Product name: Dehydrocorydaline(chloride)
Purity: 98.64%
Packaging: 5mg
Price: $228
Updated: 2021/12/16

Apolloscientific

Product number: BISN0281
Product name: Dehydrocorydaline chloride
Packaging: 5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-6061
Product name: Dehydrocorydaline(chloride)
Purity: 98.64%
Packaging: 10mg
Price: $348
Updated: 2021/12/16

Apolloscientific

Product number: BISN0281
Product name: Dehydrocorydaline chloride
Packaging: 10mg
Price: $378
Updated: 2021/12/16

ApexBio Technology

Product number: N2090
Product name: Dehydrocorydalinechloride
Packaging: 20mg
Price: $450
Updated: 2021/12/16

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Dehydrocorydaline chloride Chemical Properties,Usage,Production

Biological Activity

Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid isolated from the traditional Chinese medicine Corydalis yanhusuo. It regulates Bax, Bcl-2 protein expression; activates caspase-7, caspase-8, and inactivates PARP. Also Dehydrocorydaline chloride can enhance the activation of p38 MAPK and has anti-inflammatory and anti-cancer effects. .

in vitro

Dehydrocorydaline significantly inhibits MCF-7 cell proliferation in a dose-dependent manner, which can be reversed by a caspase-8 inhibitor, Z-IETD-FMK. Dehydrocorydaline increases DNA fragments without affecting ΔΨm. Western blotting assay shows that dehydrocorydaline dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression.

in vivo

Dehydrocorydaline (3.6, 6 or 10 mg/kg, ip) shows a dose-dependent anticiceptive effect in the acetic acid-induced writhing test and significantly attenuates the formalin-induced pain responses in mice. In the formalin test , dehydrocorydaline decreases the expression of caspase 6 (CASP6), TNF-α, IL-1β and IL-6 proteins in the spinal cord. These findings confirm that Dehydrocorydaline has antinociceptive effects in mice.

target

p38 MAPK

Dehydrocorydaline chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Dehydrocorydaline chloride Suppliers

China 20 United States 7 Global 27

MedChemexpress LLC

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Zhengzhou convergence chemical co., LTD

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13-Methylpalmatine chloride

inhibit,Bcl-2 Family,Dehydrocorydaline chloride,Autophagy,PARP,poly ADP ribose polymerase,Caspase,13-Methylpalmatine,Dehydrocorydaline,p38 MAPK,Parasite,Inhibitor

2,3,9,10-Tetramethoxy-13-methyl-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium chloride

10605-03-5