Dehydrocorydaline chloride
- Product Name
- Dehydrocorydaline chloride
- CAS No.
- 10605-03-5
- Chemical Name
- Dehydrocorydaline chloride
- Synonyms
- Dehydrocorydaline chloride;13-Methylpalmatine chloride;Dehydrocorydaline chloride, 99.95%;Dehydrocorydaline chloride, 10 mM in DMSO;2,3,9,10-Tetramethoxy-13-methyl-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium chloride;inhibit,Bcl-2 Family,Dehydrocorydaline chloride,Autophagy,PARP,poly ADP ribose polymerase,Caspase,13-Methylpalmatine,Dehydrocorydaline,p38 MAPK,Parasite,Inhibitor
- CBNumber
- CB63152944
- Molecular Formula
- C22H24ClNO4
- Formula Weight
- 401.88326
- MOL File
- 10605-03-5.mol
Dehydrocorydaline chloride Property
- Melting point:
- 191-193 °C (decomp)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 20 mg/ml
- form
- A solid
- color
- Light yellow to yellow
Safety
- HS Code
- 2933399990
- Toxicity
- mouse,LD50,intravenous,9500ug/kg (9.5mg/kg),United States Patent Document. Vol. #3849561,
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H316Causes mild skin irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-6061
- Product name
- Dehydrocorydaline(chloride)
- Purity
- 98.64%
- Packaging
- 5mg
- Price
- $228
- Updated
- 2021/12/16
- Product number
- BISN0281
- Product name
- Dehydrocorydaline chloride
- Packaging
- 5mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-6061
- Product name
- Dehydrocorydaline(chloride)
- Purity
- 98.64%
- Packaging
- 10mg
- Price
- $348
- Updated
- 2021/12/16
- Product number
- BISN0281
- Product name
- Dehydrocorydaline chloride
- Packaging
- 10mg
- Price
- $378
- Updated
- 2021/12/16
- Product number
- N2090
- Product name
- Dehydrocorydalinechloride
- Packaging
- 20mg
- Price
- $450
- Updated
- 2021/12/16
Dehydrocorydaline chloride Chemical Properties,Usage,Production
Uses
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP[1]. Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities[2]. Dehydrocorydaline chloride shows strong anti-malarial effects (IC50?=38 nM), and low cytotoxicity (cell viability?>?90%) using P. falciparum 3D7 strain[3].
Biological Activity
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid isolated from the traditional Chinese medicine Corydalis yanhusuo. It regulates Bax, Bcl-2 protein expression; activates caspase-7, caspase-8, and inactivates PARP. Also Dehydrocorydaline chloride can enhance the activation of p38 MAPK and has anti-inflammatory and anti-cancer effects. .
in vitro
Dehydrocorydaline significantly inhibits MCF-7 cell proliferation in a dose-dependent manner, which can be reversed by a caspase-8 inhibitor, Z-IETD-FMK. Dehydrocorydaline increases DNA fragments without affecting ΔΨm. Western blotting assay shows that dehydrocorydaline dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression.
in vivo
Dehydrocorydaline (3.6, 6 or 10 mg/kg, ip) shows a dose-dependent anticiceptive effect in the acetic acid-induced writhing test and significantly attenuates the formalin-induced pain responses in mice. In the formalin test , dehydrocorydaline decreases the expression of caspase 6 (CASP6), TNF-α, IL-1β and IL-6 proteins in the spinal cord. These findings confirm that Dehydrocorydaline has antinociceptive effects in mice.
target
p38 MAPK
IC 50
Plasmodium
References
[1] Xu Z, et al. Dehydrocorydaline inhibits breast cancer cells proliferation by inducing apoptosis in MCF-7 cells. Am J Chin Med. 2012;40(1):177-85. DOI:10.1142/S0192415X12500140
[2] Yoo M, et al. Dehydrocorydaline promotes myogenic differentiation via p38 MAPK activation. Mol Med Rep. 2016 Oct;14(4):3029-36. DOI:10.3892/mmr.2016.5653
[3] Nonaka M, et al. Screening of a library of traditional Chinese medicines to identify anti-malarial compounds and extracts. Malar J. 2018 Jun 25;17(1):244. DOI:10.1186/s12936-018-2392-4
[4] Yin ZY, et al. Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines. Sci Rep. 2016 Jun 7;6:27129 DOI:10.1038/srep27129
Dehydrocorydaline chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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