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Dehydrocorydaline chloride

Product Name
Dehydrocorydaline chloride
CAS No.
10605-03-5
Chemical Name
Dehydrocorydaline chloride
Synonyms
Dehydrocorydaline chloride;13-Methylpalmatine chloride;Dehydrocorydaline chloride, 99.95%;2,3,9,10-Tetramethoxy-13-methyl-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium chloride;inhibit,Bcl-2 Family,Dehydrocorydaline chloride,Autophagy,PARP,poly ADP ribose polymerase,Caspase,13-Methylpalmatine,Dehydrocorydaline,p38 MAPK,Parasite,Inhibitor
CBNumber
CB63152944
Molecular Formula
C22H24ClNO4
Formula Weight
401.88326
MOL File
10605-03-5.mol
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Dehydrocorydaline chloride Property

Melting point:
191-193 °C (decomp)
storage temp. 
Store at -20°C
solubility 
DMSO: 20 mg/ml
form 
A solid
color 
Light yellow to yellow
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Safety

HS Code 
2933399990
Toxicity
mouse,LD50,intravenous,9500ug/kg (9.5mg/kg),United States Patent Document. Vol. #3849561,
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H316Causes mild skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-6061
Product name
Dehydrocorydaline(chloride)
Purity
98.64%
Packaging
5mg
Price
$228
Updated
2021/12/16
Apolloscientific
Product number
BISN0281
Product name
Dehydrocorydaline chloride
Packaging
5mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-6061
Product name
Dehydrocorydaline(chloride)
Purity
98.64%
Packaging
10mg
Price
$348
Updated
2021/12/16
Apolloscientific
Product number
BISN0281
Product name
Dehydrocorydaline chloride
Packaging
10mg
Price
$378
Updated
2021/12/16
ApexBio Technology
Product number
N2090
Product name
Dehydrocorydalinechloride
Packaging
20mg
Price
$450
Updated
2021/12/16
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Dehydrocorydaline chloride Chemical Properties,Usage,Production

Biological Activity

Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid isolated from the traditional Chinese medicine Corydalis yanhusuo. It regulates Bax, Bcl-2 protein expression; activates caspase-7, caspase-8, and inactivates PARP. Also Dehydrocorydaline chloride can enhance the activation of p38 MAPK and has anti-inflammatory and anti-cancer effects. .

in vitro

Dehydrocorydaline significantly inhibits MCF-7 cell proliferation in a dose-dependent manner, which can be reversed by a caspase-8 inhibitor, Z-IETD-FMK. Dehydrocorydaline increases DNA fragments without affecting ΔΨm. Western blotting assay shows that dehydrocorydaline dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression.

in vivo

Dehydrocorydaline (3.6, 6 or 10 mg/kg, ip) shows a dose-dependent anticiceptive effect in the acetic acid-induced writhing test and significantly attenuates the formalin-induced pain responses in mice. In the formalin test , dehydrocorydaline decreases the expression of caspase 6 (CASP6), TNF-α, IL-1β and IL-6 proteins in the spinal cord. These findings confirm that Dehydrocorydaline has antinociceptive effects in mice.

target

p38 MAPK

Dehydrocorydaline chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Dehydrocorydaline chloride Suppliers

MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
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United States
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4861
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58
Musechem
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+1-800-259-7612
Fax
+1-800-259-7612
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info@musechem.com
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United States
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
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58
TargetMol Chemicals Inc.
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Email
support@targetmol.com
Country
United States
ProdList
38631
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58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
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52924
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Cayman Chemical Company
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Email
cayman@caymanchem.com
Country
United States
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MedChemExpress
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Email
sales@medchemexpress.com
Country
United States
ProdList
6398
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58

10605-03-5, Dehydrocorydaline chlorideRelated Search:


  • Dehydrocorydaline chloride
  • Dehydrocorydaline chloride, 99.95%
  • 13-Methylpalmatine chloride
  • inhibit,Bcl-2 Family,Dehydrocorydaline chloride,Autophagy,PARP,poly ADP ribose polymerase,Caspase,13-Methylpalmatine,Dehydrocorydaline,p38 MAPK,Parasite,Inhibitor
  • 2,3,9,10-Tetramethoxy-13-methyl-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium chloride
  • 10605-03-5