8-Hydroxy-6-quinolinecarboxylic acid

Product Name: 8-Hydroxy-6-quinolinecarboxylic acid
CAS No.: 90800-42-3
Chemical Name: 8-Hydroxy-6-quinolinecarboxylic acid
Synonyms: 3-Oxetanol,6-ethynyl-;Moxifloxacin Impurity 231;8-Hydroxy-6-quinolinecarboxylic aci;8-Hydroxyquinoline-6-carboxylic acid;8-Hydroxy-6-quinolinecarboxylic acid;6-Quinolinecarboxylic acid, 8-hydroxy-;1,4-Benzenedicarbonitrile,2,10-dibromo-;1H-Benzimidazole-1-carboxylicacid,2,3-dihydro-7-oxo-,ethylester
CBNumber: CB63153097
Molecular Formula: C10H7NO3
Formula Weight: 189.17
MOL File: 90800-42-3.mol

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8-Hydroxy-6-quinolinecarboxylic acid Property

Melting point:: 284 °C(Solv: acetic acid (64-19-7))
Boiling point:: 431.7±35.0 °C(Predicted)
Density: 1.480±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 2.93±0.30(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Activate Scientific

Product number: AS146730
Product name: 8-Hydroxyquinoline-6-carboxylicacid
Purity: 95%
Packaging: 250mg
Price: $142
Updated: 2021/12/16

Activate Scientific

Product number: AS146730
Product name: 8-Hydroxyquinoline-6-carboxylicacid
Purity: 95%
Packaging: 1g
Price: $332
Updated: 2021/12/16

Ambeed

Product number: A273835
Product name: 8-Hydroxyquinoline-6-carboxylicacid
Purity: 95%
Packaging: 100mg
Price: $26
Updated: 2021/12/16

Ambeed

Product number: A273835
Product name: 8-Hydroxyquinoline-6-carboxylicacid
Purity: 95%
Packaging: 250mg
Price: $50
Updated: 2021/12/16

Alichem

Product number: 90800423
Product name: 8-Hydroxyquinoline-6-carboxylicacid
Packaging: 100mg
Price: $263.46
Updated: 2021/12/16

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8-Hydroxy-6-quinolinecarboxylic acid Chemical Properties,Usage,Production

Synthesis

2374-03-0

107-02-8

90800-42-3

General procedure for the synthesis of 8-hydroxyquinoline-6-carboxylic acid from 4-amino-3-hydroxybenzoic acid and acrolein [stabilized]: acrolein (21.8 mL, 326 mmol) was added slowly and dropwise to an aqueous 12 N solution (50 mL) containing 4-amino-3-hydroxybenzoic acid (5.00 g, 33.0 mmol). The reaction mixture was heated to reflux for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. The resulting residue was purified by reversed-phase chromatography (elution gradient: water:CH3CN 100:0 to 50:50), resulting in the target product 8-hydroxyquinoline-6-carboxylic acid (561 mg, 9% yield). The product was analyzed by UPLC/MS (ES+) and showed m/z 190.04 [M+H]+.

References

[1] Journal of Medicinal Chemistry, 2013, vol. 56, # 2, p. 521 - 533
[2] Patent: WO2015/26792, 2015, A1. Location in patent: Paragraph 0421

8-Hydroxy-6-quinolinecarboxylic acid Preparation Products And Raw materials

Raw materials

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90800-42-3, 8-Hydroxy-6-quinolinecarboxylic acidRelated Search:

8-Hydroxy-6-quinolinecarboxylic acid

8-Hydroxyquinoline-6-carboxylic acid

6-Quinolinecarboxylic acid, 8-hydroxy-

1,4-Benzenedicarbonitrile,2,10-dibromo-

1H-Benzimidazole-1-carboxylicacid,2,3-dihydro-7-oxo-,ethylester

3-Oxetanol,6-ethynyl-

8-Hydroxy-6-quinolinecarboxylic aci

Moxifloxacin Impurity 231

90800-42-3