MMAF-OMe

Product Name: MMAF-OMe
CAS No.: 863971-12-4
Chemical Name: MMAF-OMe
Synonyms: MMAF-OMe;MMAF-OMe, 10 mM in DMSO;MONOMETHYL AURISTATIN F METHYL ESTER;ADC Payload,Inhibitor,MMAF-OMe,inhibit,MMAFOMe,MMAF OMe,ADC Cytotoxin;L-Phenylalanine, N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-, methyl ester;Methyl ((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalaninate
CBNumber: CB63154034
Molecular Formula: C40H67N5O8
Formula Weight: 746
MOL File: 863971-12-4.mol

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MMAF-OMe Property

Boiling point:: 871.8±65.0 °C(Predicted)
Density: 1.095±0.06 g/cm3(Predicted)
pka: 13.89±0.46(Predicted)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6020
Product name: MMAF-OMe
Purity: 96.88%
Packaging: 2mg
Price: $264
Updated: 2021/12/16

ChemScene

Product number: CS-6020
Product name: MMAF-OMe
Purity: 96.88%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611400
Product name: MMAF-OMe
Packaging: 5mg
Price: $569.5
Updated: 2021/12/16

ChemScene

Product number: CS-6020
Product name: MMAF-OMe
Purity: 96.88%
Packaging: 10mg
Price: $660
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611400
Product name: MMAF-OMe
Packaging: 10mg
Price: $674.9
Updated: 2021/12/16

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MMAF-OMe Chemical Properties,Usage,Production

Uses

MMAF-Ome, an antitubulin agent, is also an ADC cytotoxin. MMAF-Ome inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively.

IC 50

Auristatin

References

[1] Currier NV, et al. Targeted Drug Delivery with an Integrin-Binding Knottin-Fc-MMAF Conjugate Produced by Cell-Free Protein Synthesis. Mol Cancer Ther. 2016 Jun;15(6):1291-300 DOI:10.1158/1535-7163.MCT-15-0881

MMAF-OMe Preparation Products And Raw materials

Raw materials

Preparation Products

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MMAF-OMe Suppliers

China 32 India 1 United States 6 Global 39

MedChemexpress LLC

Tel: 021-58955995
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Tianjin Chempharmatech Co.,Ltd.

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Shanghai Send Pharmaceutical Technology Co., Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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Musechem

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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Email: marketing@targetmol.com
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Shanghai Haoyuan Chemexpress Co., Ltd.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Shanghai Zeye Biotechnology Co., Ltd.

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863971-12-4, MMAF-OMeRelated Search:

MMAF-OMe

MONOMETHYL AURISTATIN F METHYL ESTER

L-Phenylalanine, N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-, methyl ester

ADC Payload,Inhibitor,MMAF-OMe,inhibit,MMAFOMe,MMAF OMe,ADC Cytotoxin

Methyl ((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalaninate

MMAF-OMe, 10 mM in DMSO

863971-12-4