ChemicalBook > CAS DataBase List > (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride

Product Name
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
CAS No.
1448189-80-7
Chemical Name
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
Synonyms
VHL Ligand 1;ULM-1;ULM-1(MDK7526HCL);VHL Ligand 1 HCl salt;141003;CS-2718;ULM-1 HCl;UBI-10003;MDK7526 HCl;MDK-7526;ULM-1
CBNumber
CB63156669
Molecular Formula
C22H31ClN4O3S
Formula Weight
467.03
MOL File
1448189-80-7.mol
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(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride Property

storage temp. 
2-8°C
solubility 
DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 10 mg/ml
form 
A crystalline solid
color 
White to yellow
InChIKey
JYRTWGCWUBURGU-XIMRXPCLNA-N
SMILES
C([C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)(=O)NCC1C=CC(C2=C(N=CS2)C)=CC=1.Cl |&1:1,3,9,r|
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Safety

HS Code 
2934100090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
901490
Product name
(S,R,S)-AHPC hydrochloride
Purity
≥97%
Packaging
100MG
Price
$522
Updated
2023/06/20
Cayman Chemical
Product number
21591
Product name
VHL Ligand 1 (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$72
Updated
2024/03/01
Cayman Chemical
Product number
21591
Product name
VHL Ligand 1 (hydrochloride)
Purity
≥95%
Packaging
25mg
Price
$151
Updated
2024/03/01
Cayman Chemical
Product number
21591
Product name
VHL Ligand 1 (hydrochloride)
Purity
≥95%
Packaging
50mg
Price
$249
Updated
2024/03/01
Cayman Chemical
Product number
21591
Product name
VHL Ligand 1 (hydrochloride)
Purity
≥95%
Packaging
100mg
Price
$353
Updated
2024/03/01
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(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride Chemical Properties,Usage,Production

Description

VHL ligand 1 is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs). It is the von Hippel-Lindau (VHL) E3 ligase binding portion of some VHL-based PROTACs, including BET PROTAC MZ1 (Item No. 21622).

Uses

(2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide Hydrochloride acts as a reagent in the synthesis of PROTAC compounds that mediated the degration of oncogenic c-ABL and BCR-ABL.

Uses

(S,R,S)-AHPC (HCl salt) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This (S,R,S) conformation is the active variant, and (S,S,S) is the inactive derivative (cat#901487) used as a negative control.

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride Suppliers

China 136 India 2 United Kingdom 1 United States 9 Global 148
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
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View Lastest Price from (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride manufacturers

Zhengzhou Anbu Chem Co.,Ltd
Product
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride 1448189-80-7
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1000KGS
Release date
2023-11-06
Xian confluore Biological Technology Co., Ltd.
Product
(S,R,S)-AHPC hydrochloride 1448189-80-7
Price
US $0.00/g
Min. Order
10g
Purity
>95.00%
Supply Ability
10g
Release date
2024-04-01
PNP Biotech Co. Ltd
Product
MDK-7526 HCl 1448189-80-7
Price
US $0.00/kg
Min. Order
25kg
Purity
98%-99%
Supply Ability
Inquiry
Release date
2022-09-16

1448189-80-7, (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochlorideRelated Search:

Cereblon Ligand 1 4-Hydroxy ThalidoMide Protein degrader 1 (TFA) 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-

  • (S,R,S)-AHPC hydrochloride
  • MDK-7526;ULM-1
  • (4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide hydrochloride
  • Protein degrader 1
  • 141003
  • (2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide hydrochloride
  • CS-2718
  • Degradation Inducing Moiety A
  • PROTEIN DEGRADER 1 HYDROCHLORIDE; MDK7526 HCL; MDK7526; MDK-7526; MDK 7526; VHL LIGAND 1; ULM-1; VH032 DESACETYL HYDROCHLORIDE; VH032 AMINE HCL; DEGRADATION INDUCING MOIETY A;
  • VH032 amine HCl
  • VH032 desacetyl Hydrochloride
  • VHL Ligand 1
  • (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
  • Protein degrader 1 (hydrochloride)
  • ULM-1
  • MDK7526 HCl
  • (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine
  • ULM-1(MDK7526HCL)
  • VHL Ligand 1 (hydrochloride)
  • PROTAC-VHL-Ligand 1
  • ULM-1 HCl
  • PROTAC-VHL-ligand hydrochloride
  • VHL Ligand 1 HCl salt
  • (S,R,S)-AHPC hydrochloride >=97%
  • MDK7526(Protein degrader 1)
  • (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride ISO 9001：2015 REACH
  • VH032-NH2 hydrochloride
  • VHL ligand 1 hydrochlorid
  • Protein degrader 1 HCl)
  • ULM-1HCl (MDK7526 HCl
  • UBI-10003
  • (S,R,S)-AHPC (VH032-NH2) hydrochloride
  • L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-, HCl
  • (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, E3 Ligase ligand, Ligand for PROTAC? research, VH032
  • (S,R,S)-AHPC (monohydrochloride)
  • 1448189-80-7