Cenicriviroc

Product Name: Cenicriviroc
CAS No.: 497223-28-6
Chemical Name: Cenicriviroc
Synonyms: TAK-652 Mesylate;TBR-652) mesylate;Cenicriviroc mesilate;TBR-652 Mesylate,TAK652,TAK 652;Cenicriviroc Mesylate,TAK-652 Mesylate;CENICRIVIROC MESYLATE; TAK-652; TAK652; TAK 652; TBR-652; TBR 652; TBR652; CENICRIVIROC.;(5E)-8-[4-(2-Butoxyethoxy)phenyl]-1-isobutyl-N-(4-{(S)-[(1-propyl-1H-imidazol-5-yl)methyl]sulfinyl}phenyl)-1,2,3,4-tetrahydro-1-benzazocine-5-carboxamide;(S)-8-(4-(2-Butoxyethoxy)phenyl)-1-isobutyl-N-(4-(((1-propyl-1H-imidazol-5-yl)methyl)sulfinyl)phenyl)-1,2,3,4-tetrahydrobenzo[b]azocine-5-carboxamide methanesulfonate;(S,E)-8-(4-(2-butoxyethoxy)phenyl)-1-isobutyl-N-(4-(((1-propyl-1H-imidazol-5-yl)methyl)sulfinyl)phenyl)-1,2,3,4-tetrahydrobenzo[b]azocine-5-carboxamide methanesulfonate;(5E)-8-[4-(2-Butoxyethoxy)phenyl]-1-isobutyl-N-(4-{(S)-[(1-propyl-1H-imidazol-5-yl)methyl]sulfinyl}phenyl)-1,2,3,4-tetrahydro-1-benzazocine-5-carboxamide methanesulfonate (1:1
CBNumber: CB63159882
Molecular Formula: C41H52N4O4S.CH4O3S
Formula Weight: 793.05
MOL File: 497223-28-6.mol

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Cenicriviroc Property

Melting point:: 145.5-147.5 °C(Solv: 2-butanone (78-93-3))
storage temp.: Store at -20°C
solubility: DMSO:100.0(Max Conc. mg/mL);126.1(Max Conc. mM)
form: Solid
color: Light yellow to yellow
InChIKey: IXPBPUPDRDCRSY-MXSQBSGCNA-N
SMILES: C(N1CCCC(=CC2=CC(C3C=CC(=CC=3)OCCOCCCC)=CC=C21)C(=O)NC1C=CC(=CC=1)[S@@](=O)CC1=CN=CN1CCC)C(C)C.S(O)(=O)(=O)C |c:5,&1:36,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML4105
Product name: Cenicriviroc mesylate
Purity: ≥98% (HPLC)
Packaging: 1 unit
Price: $649
Updated: 2025/07/31

ChemScene

Product number: CS-0032631
Product name: CenicrivirocMesylate
Purity: 98.84%
Packaging: 50mg
Price: $880
Updated: 2021/12/16

ChemScene

Product number: CS-0032631
Product name: CenicrivirocMesylate
Purity: 98.84%
Packaging: 1mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-0032631
Product name: CenicrivirocMesylate
Purity: 98.84%
Packaging: 5mg
Price: $160
Updated: 2021/12/16

ChemScene

Product number: CS-0032631
Product name: CenicrivirocMesylate
Purity: 98.84%
Packaging: 10mg
Price: $260
Updated: 2021/12/16

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Cenicriviroc Chemical Properties,Usage,Production

Uses

Cenicriviroc Mesylate can be used as farnesoid X receptor (FXR) agonists.

in vivo

Cenicriviroc Mesylate (CVC) treatment leads to dose-related decrease in monocyte/macrophage recruitment, and achieving statistical significance at doses ≥20 mg/kg/day (p<0.05). Compare to the vehicle-control group, peritoneal lavage monocyte/macrophage counts are decreased by: 5.7%, 45.2%, 76.5% and 26.0% for Cenicriviroc Mesylate 5 twice daily (BID), Cenicriviroc Mesylate20 twice daily (BID), Cenicriviroc Mesylate100 BID, Cenicriviroc Mesylate 20 once-daily (QD), respectively. Exposure to Cenicriviroc Mesylate is dose-related and correlated with the decrease in monocyte/macrophage recruitment, with Cenicriviroc Mesylate appearing to be more effective when given BID versus QD, in line with the higher plasma concentrations achieved with BID dosing and the known short half-life in mice (~2 hours)^[1].

IC 50

CCR5: 0.29 nM (IC₅₀); CCR2: 5.9 nM (IC₅₀); R5 HIV-1: 0.024-0.08 nM (IC₅₀, in PBMCs); R5 HIV-2: 0.03-0.98 nM (IC₅₀, in PBMCs)

Cenicriviroc Preparation Products And Raw materials

Raw materials

Preparation Products

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Cenicriviroc Suppliers

China 33 United States 4 Global 37

Chengdu DingDang Pharmaceutical Co., Ltd.

Tel: 028-86040038 13980902949;
Fax: 028-85149890
Email: market@dingdangchem.com
Country: China
ProdList: 1854
Advantage: 55

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 28-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 510
Advantage: 57

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 18971495150;
Email: sales@sun-shinechem.com
Country: China
ProdList: 1112
Advantage: 64

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185;
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
Advantage: 58

Chengdu Better Pharmaceutical Technology Co.,Ltd.

Tel: 18280102635; 18280102635
Fax: 028-82252524
Email: sales@betterwanhe.com
Country: China
ProdList: 61
Advantage: 55

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 7218
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29662
Advantage: 68

Wuhan Sun-shine Bio-technology Corporation Limited

Tel: +86-027-6552-2453
Email: sales@sun-shinechem.com
Country: China
ProdList: 727
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

497223-28-6, CenicrivirocRelated Search:

TBR-652) mesylate

(5E)-8-[4-(2-Butoxyethoxy)phenyl]-1-isobutyl-N-(4-{(S)-[(1-propyl-1H-imidazol-5-yl)methyl]sulfinyl}phenyl)-1,2,3,4-tetrahydro-1-benzazocine-5-carboxamide methanesulfonate (1:1

(5E)-8-[4-(2-Butoxyethoxy)phenyl]-1-isobutyl-N-(4-{(S)-[(1-propyl-1H-imidazol-5-yl)methyl]sulfinyl}phenyl)-1,2,3,4-tetrahydro-1-benzazocine-5-carboxamide

CENICRIVIROC MESYLATE; TAK-652; TAK652; TAK 652; TBR-652; TBR 652; TBR652; CENICRIVIROC.

Cenicriviroc mesilate

TAK-652 Mesylate

(S,E)-8-(4-(2-butoxyethoxy)phenyl)-1-isobutyl-N-(4-(((1-propyl-1H-imidazol-5-yl)methyl)sulfinyl)phenyl)-1,2,3,4-tetrahydrobenzo[b]azocine-5-carboxamide methanesulfonate

1-Benzazocine-5-carboxamide,8-[4-(2-butoxyethoxy)phenyl]-1,2,3,4-tetrahydro-1-(2-methylpropyl)-N-[4-[(S)-[(1-propyl-1H-imidazol-5-yl)methyl]sulfinyl]phenyl]-,monomethanesulfonate

Cenicriviroc Mesylate,TAK-652 Mesylate

TBR-652 Mesylate,TAK652,TAK 652

(S)-8-(4-(2-Butoxyethoxy)phenyl)-1-isobutyl-N-(4-(((1-propyl-1H-imidazol-5-yl)methyl)sulfinyl)phenyl)-1,2,3,4-tetrahydrobenzo[b]azocine-5-carboxamide methanesulfonate

1-Benzazocine-5-carboxamide, 8-[4-(2-butoxyethoxy)phenyl]-1,2,3,4-tetrahydro-1-(2-methylpropyl)-N-[4-[(S)-[(1-propyl-1H-imidazol-5-yl)methyl]sulfinyl]phenyl]-, methanesulfonate (1:1)

497223-28-6