Lemborexant

Product Name: Lemborexant
CAS No.: 944252-63-5
Chemical Name: Lemborexant
Synonyms: POL7080;POL-7080;POL 7080;Murepavadin acetate;Murepavadin TFA salt;PubChem ID: 91824766;Murepavadin (POL7080);POL7080;MUREPAVADIN;POL-7080;POL 7080;Cyclo[L-alanyl-L-seryl-D-prolyl-L-prolyl-L-threonyl-L-tryptophyl-L-isoleucyl-(2S)-2,4-diaminobutanoyl-L-ornithyl-(2R)-2,4-diaminobutanoyl-(2S)-2,4-diaminobutanoyl-L-tryptophyl-(2S)-2,4-diaminobutanoyl-(2S)-2,4-diaminobutanoyl];(6S,9S,12S,15S,18S,21S,24R,27S,30S,33S,36S,39S,41aS,46aR)-18,36-Bis((1H-indol-3-yl)methyl)-12,15,21,24,30-pentakis(2-aminoethyl)-27-(3-aminopropyl)-33-((S)-sec-butyl)-39-((R)-1-hydroxyethyl)-6-(hydroxymethyl)-9-methyltriacontahydro-1H,5H-dipyrrolo[1,2-a:1',2'-d][1,4,7,10,13,16,19,22,25,28,31,34,37,40]tetradecaazacyclodotetracontine-5,8,11,14,17,20,23,26,29,32,35,38,41,46(46aH)-tetradecaone
CBNumber: CB63159923
Molecular Formula: C73H112N22O16
Formula Weight: 1553.84
MOL File: 944252-63-5.mol

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Lemborexant Property

Boiling point:: 1894.3±65.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
pka: 12.90±0.70(Predicted)
Sequence: cyclo[Ala-Ser-D-Pro-Pro-Thr-Trp-Ile-Dab-Orn-D-Dab-Dab-Trp-Dab-Dab]
InChIKey: RIDRXGOBXZLKHZ-DLVLNFPJNA-N

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC11273
Product name: Murepavadin(POL7080)
Purity: >98%
Packaging: 5mg
Price: $550
Updated: 2021/12/16

Crysdot

Product number: CD22005327
Product name: Murepavadin
Purity: 97%
Packaging: 5mg
Price: $588
Updated: 2021/12/16

Crysdot

Product number: CD22005327
Product name: Murepavadin
Purity: 97%
Packaging: 10mg
Price: $1000
Updated: 2021/12/16

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Lemborexant Chemical Properties,Usage,Production

Uses

Murepavadin (POL7080), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic. Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with both MIC50 and MIC90 values of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance[1][2].

in vivo

Murepavadin (s.c.; 0-100 mg/kg) is active in pre-clinical animal models including infections with XDR isolates^[2].

Animal Model:	murine models of P. aeruginosa infection^[2]
Dosage:	0-100 mg/kg
Administration:	Subcutaneous, q24h or q12h
Result:	Resulted in an increase in survival rate to 100% and showed significantly lower CFU levels both in the blood and in the peritoneal fluid at 2 and 10 mg/kg 1 h post-infection.

Animal Model:	Mouse, rat, rabbit, and monkey^[2]
Dosage:	0-5 mg/kg
Administration:	Intraperitoneal or subcutaneous, single
Result:	Followed a two-compartment model following intravenous administration and decline of plasma concentrations. Distributed into the aqueous phase of the body, and systemic plasma clearance (CL) values were similar to the species-specific glomerular filtration rates (GFRs) . Had high bioavailability (67.79%) after subcutaneous (s.c.) administration in rats but had low oral bioavailability (<0.01%). Had a linear relationship between ELF AUC and unbound plasma AUC in mouse. Did not readily cross the blood/brain barrier.

References

[1] Matteo Bassetti, et al. New antibiotics for ventilator-associated pneumonia. Curr Opin Infect Dis. 2018 Jan 13.
[2] Ignacio Martin-Loeches, et al. Murepavadin: a new antibiotic class in the pipeline. Expert Rev Anti Infect Ther. 2018 Apr;16(4):259-268. DOI:10.1080/14787210.2018.1441024

Lemborexant Preparation Products And Raw materials

Raw materials

Preparation Products

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Lemborexant Suppliers

China 40 United States 1 Global 41

Hangzhou Baige Pharmaceutical Technology Co. , Ltd.

Tel: 0571-85350119 15888826472
Email: 15888826472@163.com
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DC Chemicals

Tel: 021-58447131 13564518121
Email: doncunbiosci@gmail.com
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Hangzhou Beiputai Biopharmaceutical Co., Ltd

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Email: bptsales@163.com
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Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
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Guangzhou Zhiya Chemdrugs Co.,Ltd

Tel: 18122150900
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Email: sculk28@163.com
Country: China
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Shanghai YuanYe Biotechnology Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9550
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Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7617
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Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471;
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
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Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30227
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944252-63-5, LemborexantRelated Search:

Murepavadin (POL7080)

POL 7080

POL7080

POL-7080

POL7080;MUREPAVADIN;POL-7080;POL 7080

PubChem ID: 91824766

Cyclo[L-alanyl-L-seryl-D-prolyl-L-prolyl-L-threonyl-L-tryptophyl-L-isoleucyl-(2S)-2,4-diaminobutanoyl-L-ornithyl-(2R)-2,4-diaminobutanoyl-(2S)-2,4-diaminobutanoyl-L-tryptophyl-(2S)-2,4-diaminobutanoyl-(2S)-2,4-diaminobutanoyl]

Murepavadin acetate

(6S,9S,12S,15S,18S,21S,24R,27S,30S,33S,36S,39S,41aS,46aR)-18,36-Bis((1H-indol-3-yl)methyl)-12,15,21,24,30-pentakis(2-aminoethyl)-27-(3-aminopropyl)-33-((S)-sec-butyl)-39-((R)-1-hydroxyethyl)-6-(hydroxymethyl)-9-methyltriacontahydro-1H,5H-dipyrrolo[1,2-a:1',2'-d][1,4,7,10,13,16,19,22,25,28,31,34,37,40]tetradecaazacyclodotetracontine-5,8,11,14,17,20,23,26,29,32,35,38,41,46(46aH)-tetradecaone

Murepavadin TFA salt

(6S,9S,12S,15S,18S,21S,24R,27S,30S,33S,36S,39S,41aS,46aR)-18,36-Bis((1H-indol-3-yl)methyl)-12,15,21,24,30-pentakis(2-aminoethyl)-27-(3-aminopropyl)-33-((S)-sec-butyl)-39-((R)-1-hydroxyethyl)-6-(hydroxymethyl)-9-methyltriacontahydro-1H,5H-dipyrrolo[1,2-a:1',2'-d][1,4,7,10,13,16,19,22,25,28,31,34,37,40]tetradecaazacyclodotetracontine-5,8,11,14,17,20,23,26,29,32,35,38,41,46(46aH)-tetradecaone

944252-63-5

C73H112N22O16