Nusinersen

Product Name: Nusinersen
CAS No.: 1258984-36-9
Chemical Name: Nusinersen
Synonyms: NU;Nusinersen;Nusinersen Impurity;Nusinersen USP/EP/BP;Nusinersen(ASO, Oligonucleotides);Nociceptive sodium( Nociceptive sodium)
CBNumber: CB63159938
Molecular Formula: C234H340N61O128P17S17
Formula Weight: 7127.194237
MOL File: 1258984-36-9.mol

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Nusinersen Property

storage temp.: Store at -20°C
form: Solid
color: White to off-white
InChI: InChI=1S/C234H340N61O128P17S17/c1-106-66-278(224(308)261-178(106)235)205-162(356-50-32-338-14)144(119(391-205)79-373-425(320,442)407-143-117(77-296)389-204(161(143)355-49-31-337-13)282-70-110(5)193(298)271-228(282)312)410-431(326,448)383-89-129-154(172(366-60-42-348-24)215(401-129)289-99-254-135-182(239)246-95-250-186(135)289)419-436(331,453)379-81-121-145(163(357-51-33-339-15)206(393-121)279-67-107(2)179(236)262-225(279)309)408-426(321,443)375-83-123-149(167(361-55-37-343-19)210(395-123)284-72-112(7)195(300)273-230(284)314)413-429(324,446)378-86-125-150(168(362-56-38-344-20)211(397-125)285-73-113(8)196(301)274-231(285)315)414-430(325,447)377-85-124-148(166(360-54-36-342-18)209(396-124)283-71-111(6)194(299)272-229(283)313)412-428(323,445)374-80-120-147(165(359-53-35-341-17)208(392-120)281-69-109(4)181(238)264-227(281)311)411-432(327,449)384-90-130-155(173(367-61-43-349-25)216(402-130)290-100-255-136-183(240)247-96-251-187(136)290)420-437(332,454)381-87-127-152(170(364-58-40-346-22)213(399-127)287-75-115(10)198(303)276-233(287)317)415-433(328,450)385-91-131-157(175(369-63-45-351-27)218(403-131)292-102-257-138-185(242)249-98-253-189(138)292)422-440(335,457)386-92-132-156(174(368-62-44-350-26)217(404-132)291-101-256-137-184(241)248-97-252-188(137)291)421-438(333,455)382-88-128-153(171(365-59-41-347-23)214(400-128)288-76-116(11)199(304)277-234(288)318)417-435(330,452)388-94-134-159(177(371-65-47-353-29)220(406-134)295-105-260-141-192(295)267-223(245)270-202(141)307)423-439(334,456)380-82-122-146(164(358-52-34-340-16)207(394-122)280-68-108(3)180(237)263-226(280)310)409-427(322,444)376-84-126-151(169(363-57-39-345-21)212(398-126)286-74-114(9)197(302)275-232(286)316)416-434(329,451)387-93-133-158(176(370-64-46-352-28)219(405-133)294-104-259-140-191(294)266-222(244)269-201(140)306)418-424(319,441)372-78-118-142(297)160(354-48-30-336-12)203(390-118)293-103-258-139-190(293)265-221(243)268-200(139)305/h66-76,95-105,117-134,142-177,203-220,296-297H,30-65,77-94H2,1-29H3,(H,319,441)(H,320,442)(H,321,443)(H,322,444)(H,323,445)(H,324,446)(H,325,447)(H,326,448)(H,327,449)(H,328,450)(H,329,451)(H,330,452)(H,331,453)(H,332,454)(H,333,455)(H,334,456)(H,335,457)(H2,235,261,308)(H2,236,262,309)(H2,237,263,310)(H2,238,264,311)(H2,239,246,250)(H2,240,247,251)(H2,241,248,252)(H2,242,249,253)(H,271,298,312)(H,272,299,313)(H,273,300,314)(H,274,301,315)(H,275,302,316)(H,276,303,317)(H,277,304,318)(H3,243,265,268,305)(H3,244,266,269,306)(H3,245,267,270,307)/t117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,203-,204-,205-,206-,207-,208-,209-,210-,211-,212-,213-,214-,215-,216-,217-,218-,219-,220-,424?,425?,426?,427?,428?,429?,430?,431?,432?,433?,434?,435?,436?,437?,438?,439?,440?/m1/s1
InChIKey: WWFDJIVIDXJAQR-FFWSQMGZSA-N
SMILES: S=P(O[H])(OC([H])([H])[C@]1([H])[C@]([H])([C@]([H])([C@]([H])(N2C([H])=NC3=C(N([H])[H])N=C([H])N=C23)O1)OC([H])([H])C([H])([H])OC([H])([H])[H])OP(O[H])(OC([H])([H])[C@]1([H])[C@]([H])([C@]([H])([C@]([H])(N2C(N([H])C(C(C([H])([H])[H])=C2[H])=O)=O)O1)OC([H])([H])C([H])([H])OC([H])([H])[H])OP(O[H])(OC([H])([H])[C@]1([H])[C@]([H])([C@]([H])([C@]([H])(N2C([H])=NC3C(N([H])C(N([H])[H])=NC2=3)=O)O1)OC([H])([H])C([H])([H])OC([H])([H])[H])OP(O[H])(OC([H])([H])[C@]1([H])[C@]([H])([C@]([H])([C@]([H])(N2C(N=C(C(C([H])([H])[H])=C2[H])N([H])[H])=O)O1)OC([H])([H])C([H])([H])OC([H])([H])[H])OP(O[H])(OC([H])([H])[C@]1([H])[C@]([H])([C@]([H])([C@]([H])(N2C(N([H])C(C(C([H])([H])[H])=C2[H])=O)=O)O1)OC([H])([H])C([H])([H])OC([H])([H])[H])OP(O[H])(OC([H])([H])[C@]1([H])[C@]([H])([C@]([H])([C@]([H])(N2C([H])=NC3C(N([H])C(N([H])[H])=NC2=3)=O)O1)OC([H])([H])C([H])([H])OC([H])([H])[H])OP(O[H])(OC([H])([H])[C@]1([H])[C@]([H])([C@]([H])([C@]([H])(N2C([H])=NC3C(N([H])C(N([H])[H])=NC2=3)=O)O1)OC([H])([H])C([H])([H])OC([H])([H])[H])O[H])=S)=S)=S)=S)=S)=S)O[C@]1([H])[C@@]([H])(C([H])([H])OP(O[H])(O[C@]2([H])[C@@]([H])(C([H])([H])OP(O[H])(O[C@]3([H])[C@@]([H])(C([H])([H])OP(O[H])(O[C@]4([H])[C@@]([H])(C([H])([H])OP(O[H])(O[C@]5([H])[C@@]([H])(C([H])([H])OP(O[H])(O[C@]6([H])[C@@]([H])(C([H])([H])OP(O[H])(O[C@]7([H])[C@@]([H])(C([H])([H])OP(O[H])(O[C@]8([H])[C@@]([H])(C([H])([H])OP(O[H])(O[C@]9([H])[C@@]([H])(C([H])([H])OP(O[H])(O[C@]%10([H])[C@@]([H])(C([H])([H])OP(O[H])(O[C@]%11([H])[C@@]([H])(C([H])([H])O[H])O[C@]([H])([C@]%11([H])OC([H])([H])C([H])([H])OC([H])([H])[H])N%11C(N([H])C(C(C([H])([H])[H])=C%11[H])=O)=O)=S)O[C@]([H])([C@]%10([H])OC([H])([H])C([H])([H])OC([H])([H])[H])N%10C(N=C(C(C([H])([H])[H])=C%10[H])N([H])[H])=O)=S)O[C@]([H])([C@]9([H])OC([H])([H])C([H])([H])OC([H])([H])[H])N9C([H])=NC%10=C(N([H])[H])N=C([H])N=C9%10)=S)O[C@]([H])([C@]8([H])OC([H])([H])C([H])([H])OC([H])([H])[H])N8C(N=C(C(C([H])([H])[H])=C8[H])N([H])[H])=O)=S)O[C@]([H])([C@]7([H])OC([H])([H])C([H])([H])OC([H])([H])[H])N7C(N([H])C(C(C([H])([H])[H])=C7[H])=O)=O)=S)O[C@]([H])([C@]6([H])OC([H])([H])C([H])([H])OC([H])([H])[H])N6C(N([H])C(C(C([H])([H])[H])=C6[H])=O)=O)=S)O[C@]([H])([C@]5([H])OC([H])([H])C([H])([H])OC([H])([H])[H])N5C(N([H])C(C(C([H])([H])[H])=C5[H])=O)=O)=S)O[C@]([H])([C@]4([H])OC([H])([H])C([H])([H])OC([H])([H])[H])N4C(N=C(C(C([H])([H])[H])=C4[H])N([H])[H])=O)=S)O[C@]([H])([C@]3([H])OC([H])([H])C([H])([H])OC([H])([H])[H])N3C([H])=NC4=C(N([H])[H])N=C([H])N=C34)=S)O[C@]([H])([C@]2([H])OC([H])([H])C([H])([H])OC([H])([H])[H])N2C(N([H])C(C(C([H])([H])[H])=C2[H])=O)=O)=S)O[C@]([H])([C@]1([H])OC([H])([H])C([H])([H])OC([H])([H])[H])N1C([H])=NC2=C(N([H])[H])N=C([H])N=C12

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Hazard and Precautionary Statements (GHS)

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Nusinersen Chemical Properties,Usage,Production

Description

Nusinersen is a prescription medication used to treat adult and paediatric spinal muscular atrophy (SMA) by improving peripheral muscle function.SMA is caused by a mutation in a gene called SMN1, which encodes for a protein important for motor neuron survival (survival motor neuron or SMN). Although a nearly identical gene (SMN2) serves as a backup to SMN1, it produces a shorter, less stable protein that does not fully compensate for the loss of the full-length protein normally produced by the SMN1 gene. In contrast, Nusinersen is an antisense oligonucleotide agent that modifies the pre-messenger RNA splicing of the SMN2 gene, thereby facilitating increased production of full-length SMN proteins^[1-2].

Uses

Nusinersen can be used to treat adult and paediatric spinal muscular atrophy (SMA) and is also able to improve respiratory function and slow the decline in lung function in paediatric SMA^[1].

References

[1] MICHELLE A FARRAR; Matthew C K. Treating adults with spinal muscular atrophy with nusinersen.[J]. Journal of Neurology, Neurosurgery, and Psychiatry, 2020. DOI:10.1136/jnnp-2020-324036.
[2] ARCHANA CHACKO. Effect of nusinersen on respiratory function in paediatric spinal muscular atrophy types 1-3.[J]. Thorax, 2022. DOI:10.1136/thoraxjnl-2020-216564.

Nusinersen Preparation Products And Raw materials

Raw materials

Preparation Products

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Nusinersen Suppliers

China 32 India 2 United States 1 Global 35

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View Lastest Price from Nusinersen manufacturers

Biopole Pharmatech Co., Ltd.

Product: Nusinersen 1258984-36-9
Price: US $0.00/g
Min. Order: 1g
Purity: 0.99
Supply Ability: 1kg
Release date: 2024-01-19

Biopole Pharmatech Co., Ltd.

Product: Nusinersen Sodium 1258984-36-9
Price: US $0.00/g
Min. Order: 1g
Purity: 99% HPLC
Supply Ability: 10kg
Release date: 2024-01-22

Dideu Industries Group Limited

Product: Nusinersen 1258984-36-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-28

1258984-36-9, NusinersenRelated Search:

NU

Nusinersen

Nusinersen USP/EP/BP

Nociceptive sodium( Nociceptive sodium)

Nusinersen Impurity

Nusinersen(ASO, Oligonucleotides)

1258984-36-9