Voxilaprevir
- Product Name
- Voxilaprevir
- CAS No.
- 57818-44-7
- Chemical Name
- Voxilaprevir
- Synonyms
- ABTL0812;ABTL-0812;ABTL 0812;ABTL0812 (ABTL 0812;α-Hydroxylinoleic acid;2-hydroxylinoleic acid);ABTL 0812;2-HYDROXYLINOLEIC ACID;9,12-Octadecadienoic acid, 2-hydroxy-, (9Z,12Z)-;(9~{Z},12~{Z})-2-hydroxyoctadeca-9,12-dienoic acid
- CBNumber
- CB63160004
- Molecular Formula
- C18H32O3
- Formula Weight
- 296.44
- MOL File
- 57818-44-7.mol
Voxilaprevir Property
- Boiling point:
- 409.7±30.0 °C(Predicted)
- Density
- 0.970±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 5 mg/mL (16.87 mM)
- pka
- 3.85±0.21(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Voxilaprevir Chemical Properties,Usage,Production
Uses
α-Hydroxylinoleic Acid is an anticancer drug. Could be used in combination with chemotherapy for treating nonsmall cell lung cancer.
Definition
ChEBI: 2-hydroxylinoleic acid is a 2-hydroxy fatty acid derived from linoleic acid. It has a role as an Arabidopsis thaliana metabolite, an antineoplastic agent, a PPARalpha agonist and a PPARgamma agonist. It is a 2-hydroxy fatty acid, a long-chain fatty acid and a HODE. It is functionally related to a linoleic acid.
in vivo
ABTL-0812 (ABTL0812; 120 mg/kg; oral gavage; 5 times per week; for 33 d) induces ER stress in human lung and pancreatic xenografts[1].
ABTL-0812 induces hallmarks of ER stress in vivo. ABTL-0812 increases ATF4 and HSPA5 expression in mice bearing MiaPaca2 and A549 xenograft, respectively[1].
| Animal Model: | Athymic female nude mice bearing MiaPaca2 and A549 xenograft models[1] |
| Dosage: | 120 mg/kg |
| Administration: | Administered by oral gavage; 5 times per week for 33 days |
| Result: | Induced ER stress in human lung and pancreatic xenografts. |
Voxilaprevir Preparation Products And Raw materials
Raw materials
Preparation Products
Voxilaprevir Suppliers
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