Voxilaprevir

Product Name: Voxilaprevir
CAS No.: 57818-44-7
Chemical Name: Voxilaprevir
Synonyms: ABTL0812;ABTL-0812;ABTL 0812;ABTL0812 (ABTL 0812;α-Hydroxylinoleic acid;2-hydroxylinoleic acid);ABTL 0812;2-HYDROXYLINOLEIC ACID;9,12-Octadecadienoic acid, 2-hydroxy-, (9Z,12Z)-;(9~{Z},12~{Z})-2-hydroxyoctadeca-9,12-dienoic acid
CBNumber: CB63160004
Molecular Formula: C18H32O3
Formula Weight: 296.44
MOL File: 57818-44-7.mol

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Voxilaprevir Property

Boiling point:: 409.7±30.0 °C(Predicted)
Density: 0.970±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 5 mg/mL (16.87 mM)
pka: 3.85±0.21(Predicted)
form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Voxilaprevir Chemical Properties,Usage,Production

Uses

α-Hydroxylinoleic Acid is an anticancer drug. Could be used in combination with chemotherapy for treating nonsmall cell lung cancer.

Definition

ChEBI: 2-hydroxylinoleic acid is a 2-hydroxy fatty acid derived from linoleic acid. It has a role as an Arabidopsis thaliana metabolite, an antineoplastic agent, a PPARalpha agonist and a PPARgamma agonist. It is a 2-hydroxy fatty acid, a long-chain fatty acid and a HODE. It is functionally related to a linoleic acid.

in vivo

ABTL-0812 (ABTL0812; 120 mg/kg; oral gavage; 5 times per week; for 33 d) induces ER stress in human lung and pancreatic xenografts^[1].
ABTL-0812 induces hallmarks of ER stress in vivo. ABTL-0812 increases ATF4 and HSPA5 expression in mice bearing MiaPaca2 and A549 xenograft, respectively^[1].

Animal Model:	Athymic female nude mice bearing MiaPaca2 and A549 xenograft models^[1]
Dosage:	120 mg/kg
Administration:	Administered by oral gavage; 5 times per week for 33 days
Result:	Induced ER stress in human lung and pancreatic xenografts.

Voxilaprevir Preparation Products And Raw materials

Raw materials

Preparation Products

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Voxilaprevir Suppliers

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57818-44-7, VoxilaprevirRelated Search:

2-hydroxylinoleic acid)

ABTL0812 (ABTL 0812

(9~{Z},12~{Z})-2-hydroxyoctadeca-9,12-dienoic acid

ABTL 0812

ABTL0812

ABTL-0812

α-Hydroxylinoleic acid

ABTL 0812;2-HYDROXYLINOLEIC ACID

9,12-Octadecadienoic acid, 2-hydroxy-, (9Z,12Z)-

57818-44-7