ChemicalBook > CAS DataBase List > CRT0066101

CRT0066101

Product Name
CRT0066101
CAS No.
1883545-60-5
Chemical Name
CRT0066101
Synonyms
CS-2578;CRT0066101 hcl;CRT0066101 2HCL;CRT0066101 (CRT-0066101;CRT0066101 dihydrochloride;2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride;Inhibitor,CRT-0066101 dihydrochloride,CRT0066101,CRT0066101 dihydrochloride,Protein kinase D,CRT-0066101,CRT 0066101,PKD,inhibit
CBNumber
CB63164875
Molecular Formula
C18H23ClN6O
Formula Weight
374.87
MOL File
1883545-60-5.mol
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CRT0066101 Property

storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥15.65 mg/mL in DMSO; ≥4.49 mg/mL in EtOH with ultrasonic
form 
solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C782018
Product name
CRT0066101
Packaging
5mg
Price
$280
Updated
2021/12/16
ApexBio Technology
Product number
A8679
Product name
CRT0066101
Packaging
10mg
Price
$150
Updated
2021/12/16
ApexBio Technology
Product number
A8679
Product name
CRT0066101
Packaging
10mM(in 1mL DMSO)
Price
$180
Updated
2021/12/16
ApexBio Technology
Product number
A8679
Product name
CRT0066101
Packaging
100mg
Price
$1800
Updated
2021/12/16
DC Chemicals
Product number
DC20928
Product name
CRT0066101
Purity
>98%
Packaging
1g
Price
$2500
Updated
2021/12/16
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CRT0066101 Chemical Properties,Usage,Production

Biological Activity

crt 0066101 is a specific inhibitor of all pkd isoforms. increasingly studies reveals that pkd family members play an important role in regulating several cellular processes and activities, including chromatin organization, golgi function, gene expression, cell survival, adhesion, motility, differentiation, dna synthesis and proliferation. by suppressing pkd, crt 0066101 is supposed to ameliorate symptoms of pancreatic cancer. [1]

in vitro

in panc-1 cell line based assays, crt0066101 was reported to reduce bromodeoxyuridine incorporation; increase cell apoptosis; suppress neurotensin-induced pkd1/2 activation; block neurotensin-induced hsp27 phosphorylation; interrupt pkd1-mediated nf-κb activation as well as down-regulate expression of nf-κb-dependent proliferative and pro-survival proteins. [1]

in vivo

in panc-1 subcutaneous xenograft model, orally administration of crt0066101 at the dosage of 80 mg/kg/d for 24 days significantly suppressed pancreatic cancer growth. moreover, when crt0066101 reached its peak concentration (12 μmol/l) in tumor model, the expression of activated pkd1/2 in the treated tumor explants was substantially decreased. it was concluded that crt0066101 given orally at 80 mg/kg/d for 21 days in panc-1 orthotropic model suppressed tumor growth potently in vivo. [1]

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> PKD2
(Cell-free assay)
TargetValue
PKD1
(Cell-free assay)
1 nM
PKD3
(Cell-free assay)
2 nM
2.5 nM

IC 50

a potent protein kinase d (pkd) antagonist with the ic50 of 1, 2.5 and 2 nm for pkd1, pkd2, pkd3 respectively.

storage

Store at -20°C

References

[1]harikumar kb, kunnumakkara1 ab, ochi n, tong z, deorukhkar a, sung b, kelland l, jamieson s, sutherland r, raynham t, charles m, bagherzadeh a, foxton c, boakes a, farooq m, maru d, diagaradjane p, matsuo y, smith j, gelovani j, krishnan s, aggarwal bb, rozengurt e, ireson cr, and guha s. a novel small-molecule inhibitor of protein kinase d blocks pancreatic cancer growth in vitro and in vivo. mol cancer ther. 2010 may. 9(5): 113646.

CRT0066101 Preparation Products And Raw materials

Raw materials

Preparation Products

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CRT0066101 Suppliers

Chuzhou KeMail Chemical Technology Co., Ltd
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0550-5196001 15000891977
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0550-5196001
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wj520wjxby@126.com
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China
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MedChemexpress LLC
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021-58955995
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sales@medchemexpress.cn
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Bide Pharmatech Ltd.
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400-164-7117 13681763483
Fax
+86-21-61629029
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product02@bidepharm.com
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China
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AdooQ Bioscience CHINA
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025-58849295 18951903616;
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025-68650336
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info@adooq.cn
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China
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696,15000506266 15000506266
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+86-21-52996696
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China
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
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Shanghai SuperLan Chemcial Technique Centre
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021-2022843681 15618226720
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+86-21-51601218
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lucy@atkchemical.com
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Beijing Solarbio Science & Tecnology Co., Ltd.
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010-50973130 4009686088
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3193328036@qq.com
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 18892239720
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010-60605840
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psaitong@jm-bio.com
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China
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1883545-60-5, CRT0066101Related Search:


  • CRT0066101 2HCL
  • CRT0066101 dihydrochloride
  • 2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride
  • CRT0066101 (CRT-0066101
  • CS-2578
  • CRT0066101 hcl
  • Inhibitor,CRT-0066101 dihydrochloride,CRT0066101,CRT0066101 dihydrochloride,Protein kinase D,CRT-0066101,CRT 0066101,PKD,inhibit
  • 1883545-60-5
  • C18H22N6O2HCl