3-Bromo-2,6-difluorobenzonitrile
- Product Name
- 3-Bromo-2,6-difluorobenzonitrile
- CAS No.
- 1250444-23-5
- Chemical Name
- 3-Bromo-2,6-difluorobenzonitrile
- Synonyms
- 3-Bromo-2,6-difluorobenzonitrile;Benzonitrile, 3-bromo-2,6-difluoro-
- CBNumber
- CB63167412
- Molecular Formula
- C7H2BrF2N
- Formula Weight
- 218
- MOL File
- 1250444-23-5.mol
3-Bromo-2,6-difluorobenzonitrile Property
- Melting point:
- 31-32°
- storage temp.
- 2-8°C
- Appearance
- White to yellow Solid
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B999098
- Product name
- 3-Bromo-2,6-difluorobenzonitrile
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 8160DM
- Product name
- 3-Bromo-2,6-difluorobenzonitrile
- Packaging
- 500mg
- Price
- $657
- Updated
- 2021/12/16
- Product number
- 070721
- Product name
- 3-Bromo-2,6-difluorobenzonitrile
- Packaging
- 1g
- Price
- $323
- Updated
- 2021/12/16
- Product number
- PC501863
- Product name
- 3-Bromo-2,6-difluorobenzonitrile
- Purity
- 97%
- Packaging
- 1g
- Price
- $348
- Updated
- 2021/12/16
- Product number
- CS-0087931
- Product name
- 3-Bromo-2,6-difluorobenzonitrile
- Packaging
- 1g
- Price
- $370
- Updated
- 2021/12/16
3-Bromo-2,6-difluorobenzonitrile Chemical Properties,Usage,Production
Synthesis
1897-52-5
1250444-23-5
General procedure for the synthesis of 3-bromo-2,6-difluorobenzonitrile from 2,6-difluorobenzonitrile: 600mL of 60% sulfuric acid was added to a 2L four-necked flask, and 139.0g (1.0 mol) of 2,6-difluorobenzonitrile was added while stirring. Under the protection of nitrogen, the reaction temperature was controlled below 35°C. 250.5 g of potassium bromate (1.5 mol) was added in 10 portions. The progress of the reaction was monitored by thin layer chromatography (TLC) and the reaction continued for 5-6 days until the raw material spot disappeared. After completion of the reaction, 800 mL of 20% ice brine solution was prepared and the reaction mixture was slowly poured into the ice brine. After the product settled, it was quickly filtered and washed with carbon tetrachloride (CCl4) to obtain the crude product, which was orange in color. The crude product was washed sequentially with 5% sodium bisulfite (NaHSO3) solution and water until it was neutral by saturated sodium carbonate (Na2CO3) solution. After drying with anhydrous sodium sulfate, it was filtered and evaporated by rotary evaporation in a water bath at 60°C to obtain a light yellow liquid. The liquid was cooled to room temperature and allowed to stand, precipitating a light yellow solid. Reduced-pressure distillation was carried out, the condensed steam was heated and the temperature of the oil bath was raised to 90°C. The vapor fraction at 58-62°C was collected and cooled to give a white solid product with a yield of 71%.
References
[1] Patent: CN104004016, 2016, B. Location in patent: Paragraph 0043; 0044; 0045
[2] Patent: CN104017021, 2016, B. Location in patent: Paragraph 0030-0034
[3] Patent: WO2013/39802, 2013, A1. Location in patent: Page/Page column 37; 38
[4] Patent: EP2755656, 2016, B1. Location in patent: Paragraph 0118; 0119
3-Bromo-2,6-difluorobenzonitrile Preparation Products And Raw materials
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