Saroglitazar (Magnesium)

Product Name: Saroglitazar (Magnesium)
CAS No.: 1639792-20-3
Chemical Name: Saroglitazar (Magnesium)
Synonyms: Saroglitazar Magnesiu;Saroglitazar D4 Mg Salt;Saroglitazar (Magnesium);Saroglitazar Magnesium, 10 mM in DMSO;magnesium (S)-2-ethoxy-3-(4-(2-(2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-1-yl)ethoxy)phenyl)propanoate;(T-4)-Bis[(αS)-α-(ethoxy-κO)-4-[2-[2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl]ethoxy]benzenepropanoato-κO]magnesium;Magnesium, bis[(αS)-α-(ethoxy-κo)-4-[2-[2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl]ethoxy]benzenepropanoato-κo]-, (T-4)-
CBNumber: CB63167634
Molecular Formula: C50H56MgN2O8S2
Formula Weight: 901.43
MOL File: 1639792-20-3.mol

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Saroglitazar (Magnesium) Property

storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (55.47 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
color: Off-white to light yellow
InChIKey: UJYFZCVPOSZDMK-UHFFFAOYSA-L
SMILES: C(O1C(C(=O)[O-][Mg+2]21[O-]C(=O)C(CC1C=CC(OCCN3C(=CC=C3C3C=CC(SC)=CC=3)C)=CC=1)O2CC)CC1C=CC(OCCN2C(=CC=C2C2C=CC(SC)=CC=2)C)=CC=1)C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3852
Product name: Saroglitazar Magnesium
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $151.05
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3852
Product name: Saroglitazar Magnesium
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $639
Updated: 2025/07/31

ChemScene

Product number: CS-6259
Product name: SaroglitazarMagnesium
Purity: 98.85%
Packaging: 10mg
Price: $720
Updated: 2021/12/16

ChemScene

Product number: CS-6259
Product name: SaroglitazarMagnesium
Purity: 98.85%
Packaging: 1mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-6259
Product name: SaroglitazarMagnesium
Purity: 98.85%
Packaging: 5mg
Price: $468
Updated: 2021/12/16

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Saroglitazar (Magnesium) Chemical Properties,Usage,Production

Uses

Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity with EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively.

Biological Activity

Potent and selective PPARα/γ agonist.

Saroglitazar is a potent and selective PPARα/γ (peroxisome proliferator-activated receptor) agonist th at exhibits lipid-lowering and insulin-sensitizing effects. Saroglitazar is approved in India for the treatment of diabetes type 2 and dyslipidemia.

in vivo

In db/db mice, 12-day treatment with Saroglitazar (0.01-3 mg/kg per day, orally) causes dose-dependent reductions in serum triglycerides (TG), free fatty acids (FFA), and glucose. The ED₅₀ for these effects is found to be 0.05, 0.19, and 0.19 mg/kg, respectively with AUC-glucose following oral glucose administration (59%) at 1 mg/kg dose. A 90-day repeated dose comparative study in Wistar rats and marmosets confirms efficacy (TG lowering) potential of Saroglitazar and has indicated low risk of PPAR-associated side effects in humans. Based on efficacy and safety profile, Saroglitazar appears to have good potential as novel therapeutic agent for treatment of dyslipidemia and diabetes^[1].

IC 50

PPARα: 0.65 pM (EC₅₀, HepG2 cell); PPARγ: 3 nM (EC₅₀, HepG2 cell)

References

[1] Jain MR, et al. Saroglitazar, a novel PPARα/γ agonist with predominant PPARα activity, shows lipid-lowering effects in preclinical models. Pharmacol Res Perspect. 2015 Jun;3(3):e00136. DOI:10.1002/prp2.136

Saroglitazar (Magnesium) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Saroglitazar (Magnesium) manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Saroglitazar Magnesium 1639792-20-3
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-07-24

1639792-20-3, Saroglitazar (Magnesium)Related Search:

Saroglitazar

Saroglitazar (Magnesium)

magnesium (S)-2-ethoxy-3-(4-(2-(2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-1-yl)ethoxy)phenyl)propanoate

Saroglitazar D4 Mg Salt

Saroglitazar Magnesiu

(T-4)-Bis[(αS)-α-(ethoxy-κO)-4-[2-[2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl]ethoxy]benzenepropanoato-κO]magnesium

Saroglitazar Magnesium, 10 mM in DMSO

Magnesium, bis[(αS)-α-(ethoxy-κo)-4-[2-[2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl]ethoxy]benzenepropanoato-κo]-, (T-4)-

1639792-20-3