KO-947

ChemicalBook > CAS DataBase List > KO-947

Product Name: KO-947
CAS No.: 1695533-89-1
Chemical Name: KO-947
Synonyms: KO-947;KO947;KO-947;KO 947;6-benzyl-3-(pyridin-4-yl)-5,6-dihydro-1H-pyrazolo[4,3-g]quinazolin-7(8H)-one;Inhibitor,ERK,KO-947,inhibit,KO 947,Extracellular signal regulated kinases,KO947;7H-Pyrazolo[4,3-g]quinazolin-7-one, 1,5,6,8-tetrahydro-6-(phenylmethyl)-3-(4-pyridinyl)-
CBNumber: CB63168747
Molecular Formula: C21H17N5O
Formula Weight: 355.39
MOL File: 1695533-89-1.mol

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KO-947 Property

Boiling point:: 704.1±60.0 °C(Predicted)
Density: 1.354±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO:66.75(Max Conc. mg/mL);187.82(Max Conc. mM)
form: A crystalline solid
pka: 13.32±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29213
Product name: KO947
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29213
Product name: KO947
Packaging: 25mg
Price: $533
Updated: 2024/03/01

Cayman Chemical

Product number: 29213
Product name: KO947
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 29213
Product name: KO947
Packaging: 10mg
Price: $243
Updated: 2024/03/01

AK Scientific

Product number: 8399EM
Product name: 6-Benzyl-3-pyridin-4-yl-5,8-dihydro-1H-pyrazolo[4,3-g]quinazolin-7-one
Packaging: 5mg
Price: $252
Updated: 2021/12/16

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KO-947 Chemical Properties,Usage,Production

Description

KO947 is an ERK inhibitor (IC₅₀ = <50 nM for ERK2). It is greater than 50-fold selective for ERK over a panel of 450 kinases. KO947 reduces phosphorylation of the ERK target p90 ribosomal S6 kinase (RSK) in A375 cancer cells containing constitutively active B-RAF^V600E with an IC₅₀ value of less than 250 nM. It inhibits proliferation of A375 cells, as well as mutant K-Ras-expressing HCT116 and H358 cancer cell lines (IC₅₀s = 50-250 nM for all).

KO-947 Preparation Products And Raw materials

Raw materials

Preparation Products

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1695533-89-1, KO-947Related Search:

KO-947

6-benzyl-3-(pyridin-4-yl)-5,6-dihydro-1H-pyrazolo[4,3-g]quinazolin-7(8H)-one

KO947;KO-947;KO 947

7H-Pyrazolo[4,3-g]quinazolin-7-one, 1,5,6,8-tetrahydro-6-(phenylmethyl)-3-(4-pyridinyl)-

Inhibitor,ERK,KO-947,inhibit,KO 947,Extracellular signal regulated kinases,KO947

1695533-89-1