(S)-1-(tert-butoxycarbonyl)-4,4-difluoropiperidine-2-carboxylic acid
- Product Name
- (S)-1-(tert-butoxycarbonyl)-4,4-difluoropiperidine-2-carboxylic acid
- CAS No.
- 1221793-42-5
- Chemical Name
- (S)-1-(tert-butoxycarbonyl)-4,4-difluoropiperidine-2-carboxylic acid
- Synonyms
- (S)-1-Boc-4,4-difluoropiperidine-2-carboxylic Acid;(S)-1-(tert-butoxycarbonyl)-4,4-difluoropiperidine-2-carboxylic acid;(S)-l-(TERTBUTOXYCARBONYL)-4, 4-DIFLUOROPIPERIDINE-2-rARRHYVI TC ACTD;(2S)-1-[(tert-butoxy)carbonyl]-4,4-difluoropiperidine-2-carboxylic acid;(2S)-1-[(tert-butoxy)carbonyl]-4,4-difluoropiperidine-2-carboxylic acid - [B89102];1,2-Piperidinedicarboxylic acid, 4,4-difluoro-, 1-(1,1-dimethylethyl) ester, (2S)-;(2S)-4,4-difluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-2-carboxylic acid
- CBNumber
- CB63170441
- Molecular Formula
- C11H17F2NO4
- Formula Weight
- 265.25
- MOL File
- 1221793-42-5.mol
(S)-1-(tert-butoxycarbonyl)-4,4-difluoropiperidine-2-carboxylic acid Property
- Boiling point:
- 356.4±42.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- pka
- 3.20±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CM303775
- Product name
- (S)-1-(tert-Butoxycarbonyl)-4,4-difluoropiperidine-2-carboxylicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $1590
- Updated
- 2021/12/16
- Product number
- 1221793425
- Product name
- (S)-1-(tert-Butoxycarbonyl)-4,4-difluoropiperidine-2-carboxylicacid
- Packaging
- 1g
- Price
- $2508.48
- Updated
- 2021/12/16
- Product number
- 1221793425
- Product name
- (S)-1-(tert-Butoxycarbonyl)-4,4-difluoropiperidine-2-carboxylicacid
- Packaging
- 5g
- Price
- $6030
- Updated
- 2021/12/16
(S)-1-(tert-butoxycarbonyl)-4,4-difluoropiperidine-2-carboxylic acid Chemical Properties,Usage,Production
Synthesis
1352342-07-4
1221793-42-5
General procedure for the synthesis of (S)-1-(tert-butoxycarbonyl)-4,4-difluoropiperidine-2-carboxylic acid from compound (CAS: 1352342-07-4): compound 2 (1.526 g, 5.462 mmol) was dissolved in tetrahydrofuran (11 mL), methanol (11 mL), and 1N aqueous potassium hydroxide (11 mL, 11 mmol). It was stirred at room temperature for 1.5 hours. Subsequently, 1N aqueous potassium hydroxide solution (5.5 mL, 5.5 mmol) was added and stirring was continued for 1 hour. After completion of the reaction, the mixture was concentrated to half the original volume, diluted with water and washed once with ether. The aqueous phase was acidified with 1N hydrochloric acid (20 mL) and extracted twice with ethyl acetate. The organic phases were combined, washed once with saturated brine, dried over anhydrous sodium sulfate and concentrated to give compound 3 (1.429 g, 98% yield). Mass spectrometry analysis showed [M-H]? = 264.2.
References
[1] Patent: WO2011/156610, 2011, A2. Location in patent: Page/Page column 102
[2] Patent: CN106928127, 2017, A. Location in patent: Paragraph 0232; 0243; 0244; 0245; 0246; 0247
[3] Patent: WO2015/5901, 2015, A1. Location in patent: Page/Page column 528; 529
(S)-1-(tert-butoxycarbonyl)-4,4-difluoropiperidine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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