2-(TRIFLUOROMETHYL)BENZOPHENONE
Application- Product Name
- 2-(TRIFLUOROMETHYL)BENZOPHENONE
- CAS No.
- 727-99-1
- Chemical Name
- 2-(TRIFLUOROMETHYL)BENZOPHENONE
- Synonyms
- o-Trifluoromethylbenzophenone;2-(TRIFLUOROMETHYL)BENZOPHENONE;2-(Trifluoromethyl)benzophenone98%;2-(TRIFLUOROMETHYL)BENZOPHENONE 99%;Phenyl[2-(trifluoromethyl)phenyl]methanone;(2-(trifluoromethyl)phenyl)(phenyl)methanone;Methanone, phenyl[2-(trifluoromethyl)phenyl]-
- CBNumber
- CB6324492
- Molecular Formula
- C14H9F3O
- Formula Weight
- 250.22
- MOL File
- 727-99-1.mol
2-(TRIFLUOROMETHYL)BENZOPHENONE Property
- Melting point:
- 60-62 °C
- Boiling point:
- 175-178 °C(Press: 31 Torr)
- Density
- 1.2778 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- color
- Off-white
- BRN
- 2375025
- InChI
- 1S/C14H9F3O/c15-14(16,17)12-9-5-4-8-11(12)13(18)10-6-2-1-3-7-10/h1-9H
- InChIKey
- JXIWJBWMQXDALU-UHFFFAOYSA-N
- SMILES
- FC(F)(F)c1ccccc1C(=O)c2ccccc2
- CAS DataBase Reference
- 727-99-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 37/39-26-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2914790090
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 233129
- Product name
- 2-(Trifluoromethyl)benzophenone
- Purity
- 99%
- Packaging
- 5g
- Price
- $77.4
- Updated
- 2023/06/20
- Product number
- T797078
- Product name
- 2-(Trifluoromethyl)benzophenone
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 2817-3-32
- Product name
- 2-(Trifluoromethyl)benzophenone
- Purity
- 98%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- PC7568
- Product name
- 2-(Trifluoromethyl)benzophenone
- Purity
- 98%
- Packaging
- 5g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- 005391
- Product name
- 2-(Trifluoromethyl)benzophenone
- Purity
- 98%
- Packaging
- 5g
- Price
- $31
- Updated
- 2021/12/16
2-(TRIFLUOROMETHYL)BENZOPHENONE Chemical Properties,Usage,Production
Application
2-(trifluoromethyl)benzophenone is an ultraviolet absorber and a pharmaceutical and pesticide chemical intermediate with wide applications in these fields. It can also be used in the synthesis of fluorine-containing polymers. Furthermore, 2-(trifluoromethyl)benzophenone is an important pharmaceutical intermediate.
Chemical Properties
yellow crystal powde
Uses
Assymmetric reduction of 2-(trifluoromethyl)benzophenone by lithium aluminium hydride treated with (S)-(+) or (R)-(−)-2 (2-iso-indolinyl)butan-1-ol has been investigated.
Synthesis Reference(s)
Tetrahedron Letters, 35, p. 1047, 1994 DOI: 10.1016/S0040-4039(00)79962-X
General Description
Assymmetric reduction of 2-(trifluoromethyl)benzophenone by lithium aluminium hydride treated with (S)-(+) or (R)-()-2 (2-iso-indolinyl)butan-1-ol has been investigated.
Synthesis
The literature Bull.Soc.Chim.France 1962, 587-93 mentions the preparation of 2-(trifluoromethyl)phenyl ketone by the Grignard reaction using the Grignard reagents m-trifluoromethylphenylmagnesium bromide and m-trifluoromethylbenzonitrile feedstock, but the Grignard reaction is difficult to industrialize.
The raw material 10 g of 2-(trifluoromethyl)benzyl methane, 100 g of solvent chloroform and 0.2 g of catalyst phosphorus pentachloride were mixed, and then 7 g of chlorine gas was passed under 100 w incandescent light, 60 reflux for 20 hours, and the reaction process was tracked by GC and NMR;
End of the reaction, cooling, adding water, extraction with chloroform, stratification, the oil layer was concentrated to get the intermediate colorless oil 2-(trifluoromethyl)phenyl dichloromethane;
Intermediate 2-(trifluoromethyl)phenyl dichloromethane, 30 grams of water, 12 grams of acetonitrile and 3 grams of sodium hydroxide were mixed and refluxed for 4 hours, cooled and filtered to obtain the crude product, which was recrystallized with ethanol to obtain 7.8 grams of the target product 2-(trifluoromethyl)phenyl ketone as white crystals.
Yield of the above two steps by recrystallization was about: 74.5%.
2-(TRIFLUOROMETHYL)BENZOPHENONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(TRIFLUOROMETHYL)BENZOPHENONE manufacturers
- Product
- 2-(Trifluoromethyl)Benzophenone 727-99-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100MT/Year
- Release date
- 2024-11-06
- Product
- 2-(Trifluoromethyl)Benzophenone 727-99-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100MT/Year
- Release date
- 2024-11-06
- Product
- 2-(Trifluoromethyl)benzophenone 727-99-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.4%
- Supply Ability
- 100 tons
- Release date
- 2022-02-21