1-(3-Chlorphenyl)piperazine Property

Melting point:

210-214°C

Boiling point:

105 °C

Density 

1.193

refractive index 

1,598-1,600

storage temp. 

-20°C Freezer, Under Inert Atmosphere

solubility 

Chloroform (Slightly), Methanol (Sparingly)

form 

Oil

pka

8.85±0.10(Predicted)

color 

Colourless to Orange

LogP

2.468

CAS DataBase Reference

6640-24-0(CAS DataBase Reference)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-36

HazardClass 

IRRITANT

HS Code 

29339900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Hazard statements

H411Toxic to aquatic life with long lasting effects

1-(3-Chlorphenyl)piperazine Chemical Properties,Usage,Production

Chemical Properties

clear colorless to light yellow oily liquid

Uses

It is noteworthy that 1-(3-Chlorphenyl)piperazine (m-CPP), resulting from N-dealkylation of Trazodone, is a major circulating metabolite in humans common to several antidepressants including Trazodone, Nefazodone, and Etoperidone (1,2,3). The metabolite m-CPP is of significant interest because it has 5-HT2C agonistic and 5-HT2A antagonistic properties. It has also been suggested that m-CPP may contribute to the antidepressant efficacy of Trazodone.

Definition

ChEBI: A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.

Hazard

A poison.