5-CHLORO-6-METHYLPYRIMIDIN-4(1H)-ONE

Product Name: 5-CHLORO-6-METHYLPYRIMIDIN-4(1H)-ONE
CAS No.: 7752-72-9
Chemical Name: 5-CHLORO-6-METHYLPYRIMIDIN-4(1H)-ONE
Synonyms: 5-Chloro-6-methylpyrimidin-4(3H);4-Chloro-6-methyl-pyrimidin-5-ol;5-Chloro-6-methyl-1H-pyrimidin-4-one;5-CHLORO-6-METHYLPYRIMIDIN-4(1H)-ONE;5-Chloro-6-MethylpyriMidin-4(3H)-one;5-Chloro-6-hydroxy-4-methylpyrimidine;4-hydroxy-5-chloro-6-methylpyrimidine;4(3H)-Pyrimidinone, 5-chloro-6-methyl-;4(1H)-Pyrimidinone, 5-chloro-6-methyl- (9CI)
CBNumber: CB6325813
Molecular Formula: C5H5ClN2O
Formula Weight: 144.56
MOL File: 7752-72-9.mol

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5-CHLORO-6-METHYLPYRIMIDIN-4(1H)-ONE Property

Melting point:: 209-211 °C
Boiling point:: 206.4±50.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 7.70±0.50(Predicted)
Appearance: White to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C384348
Product name: 5-Chloro-6-methylpyrimidin-4(1H)-one
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC154045
Product name: 5-CHLORO-6-METHYLPYRIMIDIN-4(1H)-ONE
Packaging: 250mg
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC154045
Product name: 5-CHLORO-6-METHYLPYRIMIDIN-4(1H)-ONE
Packaging: 500mg
Price: $125
Updated: 2021/12/16

AK Scientific

Product number: 2384EM
Product name: 5-Chloro-6-methylpyrimidin-4(3H)-one
Packaging: 250mg
Price: $142
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC154045
Product name: 5-CHLORO-6-METHYLPYRIMIDIN-4(1H)-ONE
Packaging: 1g
Price: $216
Updated: 2021/12/16

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5-CHLORO-6-METHYLPYRIMIDIN-4(1H)-ONE Chemical Properties,Usage,Production

Synthesis

3473-63-0

609-15-4

7752-72-9

The general procedure for the synthesis of 5-chloro-6-methylpyrimidin-4(1H)-one from formamidine acetate and ethyl 2-chloroacetoacetate was as follows: a methanolic solution of 4-hydroxy-5-chloro-6-methylpyrimidine (8.80 g, 0.16 mol) was slowly added to a 50 mL methanolic solution containing 11.30 g (0.11 mol) of formamidine acetate, and the reaction was carried out with stirring at room temperature. After the addition was completed, the mixture continued to be stirred at room temperature for 2 hours. Subsequently, 11.17 g (0.068 mol) of ethyl 2-chloro-3-oxobutanoate was added and the reaction continued to be stirred for 5-7 hours at room temperature. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was concentrated under reduced pressure, the pH was adjusted to 5-6 with hydrochloric acid (HCl) and filtered to give an orange-yellow solid. The aqueous phase was extracted with ethyl acetate (3 x 50 mL), the organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was dissolved in 50 mL of ethyl acetate and allowed to stand overnight to give 6.48 g of orange-yellow solid product in 66% yield with a melting point of 181-184°C.

References

[1] Patent: EP2913325, 2015, A1. Location in patent: Paragraph 0451; 0452
[2] Patent: CN105348298, 2016, A. Location in patent: Paragraph 0418; 0419; 0420
[3] Patent: CN105732585, 2016, A. Location in patent: Paragraph 0368; 0369; 0370
[4] Patent: CN105777717, 2016, A. Location in patent: Paragraph 0356; 0357; 0358; 0359
[5] Patent: CN104292169, 2018, B. Location in patent: Paragraph 0457; 0458; 0459

5-CHLORO-6-METHYLPYRIMIDIN-4(1H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-CHLORO-6-METHYLPYRIMIDIN-4(1H)-ONE Suppliers

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7752-72-9, 5-CHLORO-6-METHYLPYRIMIDIN-4(1H)-ONERelated Search:

5-Chloro-6-ethylpyrimidin-4-ol 5-CHLORO-4-HYDROXY-6-TRIFLUOROMETHYL-PYRIMIDINE 5-CHLORO-6-(1-FLUOROETHYL)-4(1H)-PYRIMIDINONE 5-CHLORO-6-METHYLPYRIMIDIN-4(1H)-ONE 5-CHLORO-6-METHYL-2-(2-PYRIDYL)PYRIMIDIN-4-OL 5-CHLORO-4-METHOXY-6-METHYLPYRIMIDIN-2-AMINE 5-CHLORO-4-HYDROXY-6-DIFLUOROMETHYLPYRIMIDINE 5-CHLORO-4-HYDROXY-6-ISOPROPYLPYRIMIDINE N-ALLYL-N-(5-CHLORO-4-METHOXY-6-METHYLPYRIMIDIN-2-YL)ACETAMIDE N-(5-CHLORO-4-METHOXY-6-METHYLPYRIMIDIN-2-YL)ACETAMIDE 2,5-Dichloro-4-methoxy-6-(trichloro-methyl)-pyrimidine 5-CHLORO-2,4-DIMETHOXY-6-METHYLPYRIMIDINE 2-AMINO-5-CHLORO-6-METHYLPYRIMIDIN-4-OL 2-Amino-5-chloro-6-phenyl-4(1H)-pyrimidinone 5-CHLORO-4-HYDROXY-2-METHYL-6-TRIFLUOROMETHYL-PYRIMIDINE 5-CHLORO-2-(2,6-DICHLORO-4-PYRIDYL)-6-METHYLPYRIMIDIN-4-OL 5-CHLORO-6-METHYL-2-PHENYL-4-PYRIMIDINOL

5-CHLORO-6-METHYLPYRIMIDIN-4(1H)-ONE

4(1H)-Pyrimidinone, 5-chloro-6-methyl- (9CI)

5-Chloro-6-MethylpyriMidin-4(3H)-one

4-Chloro-6-methyl-pyrimidin-5-ol

5-Chloro-6-hydroxy-4-methylpyrimidine

5-Chloro-6-methylpyrimidin-4(3H)

5-Chloro-6-methyl-1H-pyrimidin-4-one

4(3H)-Pyrimidinone, 5-chloro-6-methyl-

4-hydroxy-5-chloro-6-methylpyrimidine

7752-72-9

PYRIMIDINE