MUCONOMYCIN A Property

Melting point:

>360° (dec)

alpha 

D23 +206° (c = 1.012 in chloroform)

Boiling point:

512.66°C (rough estimate)

Density 

1.1922 (rough estimate)

refractive index 

1.5500 (estimate)

storage temp. 

−20°C

solubility 

Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble

form 

A solid

pka

12.76±0.70(Predicted)

color 

White to light yellow

Safety

Hazard Codes 

T+

Risk Statements 

26/27/28

Safety Statements 

22-36/37/39-45

RIDADR 

UN 2811 6.1/PG 1

WGK Germany 

3

RTECS 

WH1314900

HazardClass 

6.1(a)

PackingGroup 

I

HS Code 

2941900000

Toxicity

LD50 in mice, rats, rabbits (mg/kg): 1.5, 0.87, 0.54 i.v. (Rüsch, Sthlin)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

MUCONOMYCIN A Chemical Properties,Usage,Production

Uses

Verrucarin A from Myrothecium sp has been used:

• as a translation initiation inhibitor in P. falciparum W2 strain
• as a peptidyl transfer inhibitor to test sensitivity in methyltransferase knock-out S. cerevisiae cells
• to test its cytotoxicity in renal cell carcinoma cells

Definition

ChEBI: A trichothecene antibiotic which incorporates a triester macrocyclic structure and an exocyclic methylene epoxide group.

General Description

Verrucarin derived from the Myrothecium verrucari, a fungal plant pathogen is a macrocyclic trichothecene compound.

Biochem/physiol Actions

Verrucarin A binds to the P and A sites in ribosomes and blocks peptide-bond and translation initiation. It inhibits the clear cell renal cell carcinoma (CCRCC) proliferation. Verrucarin A blocks the peptidyl transferase activity and favors apoptosis induction in cancer cells