TM5441
- Product Name
- TM5441
- CAS No.
- 1190221-43-2
- Chemical Name
- TM5441
- Synonyms
- TM5441;CS-2510;TM5441 ，S6778;TM 5441;TM-5441;TM5441, 10 mM in DMSO;5-Chloro-2-(2-(2-((3-(furan-3-yl)phenyl)amino)-2-oxoethoxy)acetamido)benzoic acid;Benzoic acid, 5-chloro-2-[[2-[2-[[3-(3-furanyl)phenyl]amino]-2-oxoethoxy]acetyl]amino]-;TM 5441,PAI-1,Plasminogen activator inhibitor-1,TM5441,Inhibitor,TM-5441,inhibit,Apoptosis
- CBNumber
- CB63309542
- Molecular Formula
- C21H17ClN2O6
- Formula Weight
- 428.82
- MOL File
- 1190221-43-2.mol
TM5441 Property
- Boiling point:
- 738.6±60.0 °C(Predicted)
- Density
- 1.451±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 33 m/ml; DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml; DMSO: 20 mg/ml
- form
- A crystalline solid
- pka
- 2.87±0.10(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 22965
- Product name
- TM5441
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 22965
- Product name
- TM5441
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 22965
- Product name
- TM5441
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $214
- Updated
- 2024/03/01
- Product number
- 6194
- Product name
- TM5441
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $203
- Updated
- 2021/12/16
- Product number
- T460020
- Product name
- TM5441
- Packaging
- 5mg
- Price
- $215
- Updated
- 2021/12/16
TM5441 Chemical Properties,Usage,Production
Uses
TM5441 is a novel plasminogen activator inhibitor 1 (PAI-1). A therapeutic agent for obesity and obesity-related metabolic disorders.
Synthesis
1190222-68-4
1190221-43-2
GENERAL METHOD: Ester compound 12a (0.46 g, 1.17 mmol) was dissolved in tetrahydrofuran (4.6 mL) and 1 N aqueous sodium hydroxide solution (1.29 mL) was added. The reaction mixture was stirred at 50 °C for 3 hours. After completion of the reaction, it was cooled to room temperature and the tetrahydrofuran was removed by distillation under reduced pressure. The residue was acidified with 1 N hydrochloric acid and the resulting precipitate was collected by filtration. The precipitate was washed sequentially with water and isopropyl ether and dried under vacuum to afford the target carboxylic acid compound 24 as a solid (0.425 g, 96% yield).
in vivo
Oral administration of TM5441 (20 mg/kg daily) to HT1080 and HCT116 xenotransplanted mice increases tumor cell apoptosis and has a significant disruptive effect on the tumor vasculature that is associated with a decrease in tumor growth and an increase in survival. The average peak plasma concentration is 11.4 μM one hour after oral administration and undetectable levels 23 hours after administration[1].
TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence, prolongs lifespan in klotho null mice and elicits anti-tumorigenic and anti-angiogenic activities in cancer[3].
References
[1] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 4, p. 809 - 813
TM5441 Preparation Products And Raw materials
Raw materials
Preparation Products
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