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VUF 11207 fumarate

Product Name
VUF 11207 fumarate
CAS No.
1785665-61-3
Chemical Name
VUF 11207 fumarate
Synonyms
VUF 11207 fumarate;VUF11207 fumarate, 10 mM in DMSO;N-(3-(2-Fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide but-2-enedioate;N-[(2E)-3-(2-Fluorophenyl)-2-methyl-2-propen-1-yl]-3,4,5-trimethoxy-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]benzamide fumarate;VUF11207,Inhibitor,CXCR,TnF?α,osteoclast precursor cells,VUF-11207,LPS,CXC chemokine receptors,inhibit,osteoclastogenesis,VUF-11207 fumarate,VUF11207 fumarate,bone resorption,VUF 11207,RANKL
CBNumber
CB63311721
Molecular Formula
C31H39FN2O8
Formula Weight
586.66
MOL File
1785665-61-3.mol
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VUF 11207 fumarate Property

storage temp. 
Store at -20°C
solubility 
<58.66mg/ml in Water; <58.66mg/ml in DMSO
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
4780
Product name
VUF11207fumarate
Purity
≥98%(HPLC)
Packaging
10
Price
$231
Updated
2021/12/16
Tocris
Product number
4780
Product name
VUF11207fumarate
Purity
≥98%(HPLC)
Packaging
50
Price
$971
Updated
2021/12/16
Usbiological
Product number
257078
Product name
VUF 11207 fumarate
Packaging
10mg
Price
$489
Updated
2021/12/16
ChemScene
Product number
CS-0033233
Product name
VUF11207(fumarate)
Purity
98.50%
Packaging
50mg
Price
$600
Updated
2021/12/16
ChemScene
Product number
CS-0033233
Product name
VUF11207(fumarate)
Purity
98.50%
Packaging
100mg
Price
$1000
Updated
2021/12/16
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VUF 11207 fumarate Chemical Properties,Usage,Production

Uses

VUF11207 fumarate is a CXCR7 agonist that binds specifically to CXCR7. VUF11207 fumarate reduces CXCL12-mediated osteoclastogenesis and bone resorption by inhibiting ERK phosphorylation[1].

in vivo

VUF11207 fumarate (100 μg/day; s.c.; single daily for 5 days) inhibits LPS?induced osteoclastogenesis, bone resorption and production of RANKL and TNF?α in mice[1].

Animal Model:Male c57Bl/6J wild?type/WT mice (8?10?week?old; 20?25 g; LPS-induced)[1]
Dosage:100 μg/day
Administration:Subcutaneous injection; single daily for 5 days
Result:Significantly decreased the number of osteoclasts and suppressed Cathepsin K mRNA, ranKl and TnF?α mRNA expression levels.
Reduced the area of LPS-induced bone resorption.

IC 50

CXCR7: 8.1 (pKi)

storage

Store at -20°C

References

[1] Wijtmans M, et al. Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists. Eur J Med Chem. 2012 May;51:184-92. DOI:10.1016/j.ejmech.2012.02.041
[2] Nugraha AP, et al. C?X?C receptor 7 agonist acts as a C?X?C motif chemokine ligand 12 inhibitor to ameliorate osteoclastogenesis and bone resorption. Mol Med Rep. 2022 Mar;25(3):78. DOI:10.3892/mmr.2022.12594

VUF 11207 fumarate Preparation Products And Raw materials

Raw materials

Preparation Products

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VUF 11207 fumarate Suppliers

China 24 United Kingdom 1 United States 6 Global 31
Shanghai Beckham Medical Technology Co., Ltd
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InvivoChem
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Shanghai Aladdin Biochemical Technology Co.,Ltd.
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TargetMol Chemicals Inc.
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1785665-61-3, VUF 11207 fumarateRelated Search:

VUF 10460

  • VUF 11207 fumarate
  • N-[(2E)-3-(2-Fluorophenyl)-2-methyl-2-propen-1-yl]-3,4,5-trimethoxy-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]benzamide fumarate
  • VUF11207,Inhibitor,CXCR,TnF?α,osteoclast precursor cells,VUF-11207,LPS,CXC chemokine receptors,inhibit,osteoclastogenesis,VUF-11207 fumarate,VUF11207 fumarate,bone resorption,VUF 11207,RANKL
  • N-(3-(2-Fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide but-2-enedioate
  • VUF11207 fumarate, 10 mM in DMSO
  • 1785665-61-3