Methanone, (4-fluorophenyl)[1-[2-methoxy-2-(4-nitrophenyl)ethyl]-4-piperidinyl]-

Product Name: Methanone, (4-fluorophenyl)[1-[2-methoxy-2-(4-nitrophenyl)ethyl]-4-piperidinyl]-
CAS No.: 666859-49-0
Chemical Name: Methanone, (4-fluorophenyl)[1-[2-methoxy-2-(4-nitrophenyl)ethyl]-4-piperidinyl]-
Synonyms: Telomerase-IN-1;Antipsychotic agent 54;Telomerase IN 1,TelomeraseIN1;Telomerase-IN-1, 10 mM in DMSO;Methanone, (4-fluorophenyl)[1-[2-methoxy-2-(4-nitrophenyl)ethyl]-4-piperidinyl]-;(4-fluorophenyl)(1-(2-methoxy-2-(4-nitrophenyl)ethyl)piperidin-4-yl)methanone(WXG03041)
CBNumber: CB63339677
Molecular Formula: C21H23FN2O4
Formula Weight: 386.4167232
MOL File: 666859-49-0.mol

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Methanone, (4-fluorophenyl)[1-[2-methoxy-2-(4-nitrophenyl)ethyl]-4-piperidinyl]- Property

Boiling point:: 512.7±50.0 °C(Predicted)
Density: 1.236±0.06 g/cm3(Predicted)
pka: 7.16±0.10(Predicted)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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Methanone, (4-fluorophenyl)[1-[2-methoxy-2-(4-nitrophenyl)ethyl]-4-piperidinyl]- Chemical Properties,Usage,Production

Uses

Telomerase-IN-1 is a Telomerase inhibitor with an IC50 of 0.19 μM.

in vivo

Our in vivo studies show that this compound (Telomerase-IN-1) significantly inhibits tumor growth in xenograft tumor models. Results show that endoplasmic reticulum stress (ERS) through ER over response (EOR) activates the expression of hTERT, and then induces ERS, which is believed to be intricately associated with oxidative stress and mitochondrial dysfunction, resulting in apoptotic cell death, thereby modulating the expression of downstream signaling molecules including CHOP (CAAT/enhancer-binding protein homologous protein)) and mitochondrion pathway of apoptosis, leading to inhibition of cell proliferation^[1].

References

[1] Cheng X, et al. Discovery of (4-bromophenyl)(3-hydroxy-4-methoxyphenyl)methanone through upregulating hTERT induces cell apoptosis and ERS. Cell Death Dis. 2017 Aug 24;8(8):e3016. DOI:10.1038/cddis.2017.384

Methanone, (4-fluorophenyl)[1-[2-methoxy-2-(4-nitrophenyl)ethyl]-4-piperidinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Methanone, (4-fluorophenyl)[1-[2-methoxy-2-(4-nitrophenyl)ethyl]-4-piperidinyl]- Suppliers

China 7 United States 4 USA 1 Global 12

MedChemexpress LLC

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666859-49-0, Methanone, (4-fluorophenyl)[1-[2-methoxy-2-(4-nitrophenyl)ethyl]-4-piperidinyl]-Related Search:

Methanone, (4-fluorophenyl)[1-[2-methoxy-2-(4-nitrophenyl)ethyl]-4-piperidinyl]-

(4-fluorophenyl)(1-(2-methoxy-2-(4-nitrophenyl)ethyl)piperidin-4-yl)methanone(WXG03041)

Telomerase-IN-1

Telomerase IN 1,TelomeraseIN1

Antipsychotic agent 54

Telomerase-IN-1, 10 mM in DMSO

666859-49-0