CCT251455

Product Name: CCT251455
CAS No.: 1400284-80-1
Chemical Name: CCT251455
Synonyms: CCT251455;CCT251455,CCT-251455;BXKNUXDLZJPPBO-UHFFFAOYSA-N;1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid, 6-[[2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenyl]amino]-2-(1-methyl-1H-pyrazol-4-yl)-, 1,1-dimethylethyl ester
CBNumber: CB63339864
Molecular Formula: C26H26ClN7O2
Formula Weight: 503.98
MOL File: 1400284-80-1.mol

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CCT251455 Property

Boiling point:: 731.0±70.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 7.86±0.30(Predicted)
color: Light yellow to brown

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Hazard and Precautionary Statements (GHS)

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CCT251455 Chemical Properties,Usage,Production

Description

CCT251455 is a potent and selecltive MSP1 inhibitor with potential anticancer activitiy. The protein kinase MPS1 is a crucial component of the spindle assembly checkpoint signal and is aberrantly overexpressed in many human cancers. MPS1 is one of the top 25 genes overexpressed in tumors with chromosomal instability and aneuploidy. PTEN-deficient breast tumor cells are particularly dependent upon MPS1 for their survival, making it a target of significant interest in oncology. CCT251455 stabilizes an inactive conformation of MPS1 with the activation loop ordered in a manner incompatible with ATP and substrate-peptide binding; it displays a favorable oral pharmacokinetic profile, shows dose-dependent inhibition of MPS1 in an HCT116 human tumor xenograft model, and is an attractive tool compound to elucidate further the therapeutic potential of MPS1 inhibition.

CCT251455 Preparation Products And Raw materials

Raw materials

Preparation Products

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CCT251455 Suppliers

China 6 United States 2 Global 8

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9730
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 3852
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10000
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Shanghai tingchong biology science and technology co., ltd

Tel: 18964309092 18964309092
Email: 2769493375@qq.com
Country: China
ProdList: 2635
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24647
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9268
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52927
Advantage: 58

1400284-80-1, CCT251455Related Search:

CCT251455

BXKNUXDLZJPPBO-UHFFFAOYSA-N

CCT251455,CCT-251455

1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid, 6-[[2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenyl]amino]-2-(1-methyl-1H-pyrazol-4-yl)-, 1,1-dimethylethyl ester

1400284-80-1