ChemicalBook > CAS DataBase List > Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]-

Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]-

Product Name
Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]-
CAS No.
1380392-05-1
Chemical Name
Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]-
Synonyms
JMS-17-2, 10 mM in DMSO;5-(3-(4-(4-chlorophenyl)piperidin-1-yl)propyl)pyrrolo[1,2-a]quinoxalin-4(5H)-one;Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]-;CX3CR1,inhibit,GPR13,CX3C chemokine receptor1,fractalkine receptor,JMS 17 2,Inhibitor,JMS172
CBNumber
CB63340682
Molecular Formula
C25H26ClN3O
Formula Weight
419.95
MOL File
1380392-05-1.mol
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Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]- Property

Boiling point:
603.8±55.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO:32.5(Max Conc. mg/mL);77.39(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);23.81(Max Conc. mM)
pka
9.11±0.20(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ambeed
Product number
A278381
Product name
5-(3-(4-(4-Chlorophenyl)piperidin-1-yl)propyl)pyrrolo[1,2-a]quinoxalin-4(5H)-one
Purity
97%
Packaging
5mg
Price
$134
Updated
2021/12/16
Ambeed
Product number
A278381
Product name
5-(3-(4-(4-Chlorophenyl)piperidin-1-yl)propyl)pyrrolo[1,2-a]quinoxalin-4(5H)-one
Purity
97%
Packaging
100mg
Price
$383
Updated
2021/12/16
DC Chemicals
Product number
DC10971
Product name
JMS-17-2
Purity
>98%
Packaging
100mg
Price
$650
Updated
2021/12/16
Ambeed
Product number
A278381
Product name
5-(3-(4-(4-Chlorophenyl)piperidin-1-yl)propyl)pyrrolo[1,2-a]quinoxalin-4(5H)-one
Purity
97%
Packaging
250mg
Price
$707
Updated
2021/12/16
DC Chemicals
Product number
DC10971
Product name
JMS-17-2
Purity
>98%
Packaging
250mg
Price
$1100
Updated
2021/12/16
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Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]- Chemical Properties,Usage,Production

Uses

JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 impairs metastatic seeding and colonization of breast cancer cells[1].

in vivo

JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice[1].

Animal Model:SCID mice (~25g) with MDA-231 xenograft[1]
Dosage:10 mg/kg
Administration:Aministered i.p.; twice a day for three weeks
Result:Caused a dramatic reduction of tumors in both skeleton and visceral organs.

References

[1] Shen F, et al. Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells. Mol Cancer Res. 2016 Jun;14(6):518-27. DOI:10.1158/1541-7786.MCR-16-0013

Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]- Suppliers

China 56 United States 4 Global 60
Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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China
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Shanghaizehan biopharma technology co., Ltd.
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021-61350663 13052117465
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021-61350662
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sales@zehanbiopharma.com
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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Shanghai Rechem science Co., Ltd.
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sales@rechemscience.com
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Shanghai Chaolan Chemical Technology Center
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21-5161 9052
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Sales@ATKchemical.com
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Twochem Co.Ltd.
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021-58111628 15800915896
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QQ 3285589261
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sales@twochem.com
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Angel Pharmatech, Ltd.
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17317130613
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QQ3358272972
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3358272972@qq.com
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China
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Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312
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liming@bio-fount.com
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China
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1380392-05-1, Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]-Related Search:

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  • Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]-
  • 5-(3-(4-(4-chlorophenyl)piperidin-1-yl)propyl)pyrrolo[1,2-a]quinoxalin-4(5H)-one
  • CX3CR1,inhibit,GPR13,CX3C chemokine receptor1,fractalkine receptor,JMS 17 2,Inhibitor,JMS172
  • JMS-17-2, 10 mM in DMSO
  • 1380392-05-1
  • API