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Argatroban Impurity 23

Product Name
Argatroban Impurity 23
CAS No.
1356847-56-7
Chemical Name
Argatroban Impurity 23
Synonyms
[2H3]-Argatroban;Argatroban-d3 (hydrochloride);Argatroban-d3 (Mixture Of Diastereomers)
CBNumber
CB63359002
Molecular Formula
C23H33D3N6O5S
Formula Weight
511.652625334
MOL File
1356847-56-7.mol
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Argatroban Impurity 23 Property

storage temp. 
Store at -20°C
solubility 
DMF: soluble,DMSO: soluble,Methanol: soluble
form 
A solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25757
Product name
Argatroban-d3 (hydrochloride)
Packaging
1mg
Price
$299
Updated
2024/03/01
Cayman Chemical
Product number
25757
Product name
Argatroban-d3 (hydrochloride)
Packaging
5mg
Price
$1340
Updated
2024/03/01
TRC
Product number
A769002
Product name
Argatroban-d3
Packaging
10mg
Price
$1980
Updated
2021/12/16
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Argatroban Impurity 23 Chemical Properties,Usage,Production

Description

Argatroban-d3 is intended for use as an internal standard for the quantification of argatroban by GC- or LC-MS. Argatroban is a reversible inhibitor of thrombin (IC50s = 0.01 and 0.09 μM for the free and clot-bound forms, respectively). It is selective for thrombin over factor Xa, trypsin, plasmin, and tissue plasminogen activator (Kis = 0.0045, 53, 0.19, 25.7, and 87.7 μM, respectively). It inhibits thrombin-induced platelet aggregation in washed isolated guinea pig platelets with an IC50 value of 0.077 μM. Argatroban (3.2 mg/kg, s.c.) decreases thrombus formation in a guinea pig model of iron chloride-induced arterial thrombosis. Formulations containing argatroban have been used in the prevention or treatment of thrombosis in patients with heparin-induced thrombocytopenia.

Uses

Labelled synthetic thrombin inhibitor. Antithrombotic.

References

[1] HEE DONG PARK . Antithrombotic effects of LB30870, a potent, orally active, selective and direct thrombin inhibitor, and pharmacokinetics of its prodrug[J]. Bioorganic & Medicinal Chemistry Letters, 2013, 23 17: Pages 4779-4784. DOI: 10.1016/j.bmcl.2013.07.008
[2] YASUKO KATO . Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig[J]. European journal of pharmacology, 2003, 473 2: Pages 163-169. DOI: 10.1016/s0014-2999(03)01973-3

Argatroban Impurity 23 Preparation Products And Raw materials

Raw materials

Preparation Products

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Argatroban Impurity 23 Suppliers

Canada 1 CHINA 15 India 3 United States 2 Global 21
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Energy Chemical
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marketing1@energy-chemical.com
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Manhag Testing Technology Co., Ltd
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Foshan Treasure Biotechnology Co., Ltd
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QUALITY CONTROL SOLUTIONS LTD.
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+86-0755-66853366 +86-13670046396
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export03@qcsrm.com
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Shanghai isotope chemical co.,ltd
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Shanghai Yifei Biotechnology Co. , Ltd.
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Shanghai Beiwanta Biotechnology Co., Ltd.
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Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd
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BePure (Beijing) Biotechnology Co.
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Cayman Chemical Company
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Neobioscience Co., Ltd.
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  • Argatroban-d3 (Mixture Of Diastereomers)
  • [2H3]-Argatroban
  • Argatroban-d3 (hydrochloride)
  • 1356847-56-7