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Atabecestat

Product Name
Atabecestat
CAS No.
1200493-78-2
Chemical Name
Atabecestat
Synonyms
Atabecestat;JNJ-54861911;Atabecestat (JNJ-54861911);(S)-N-(3-(2-Amino-4-methyl-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide;2-Pyridinecarboxamide, N-[3-[(4S)-2-amino-4-methyl-4H-1,3-thiazin-4-yl]-4-fluorophenyl]-5-cyano-
CBNumber
CB63363780
Molecular Formula
C18H14FN5OS
Formula Weight
367.4
MOL File
1200493-78-2.mol
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Atabecestat Property

Density 
1.39±0.1 g/cm3(Predicted)
pka
9.90±0.70(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0031557
Product name
Atabecestat
Purity
98.76%
Packaging
5mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0031557
Product name
Atabecestat
Purity
98.76%
Packaging
10mg
Price
$750
Updated
2021/12/16
ChemScene
Product number
CS-0031557
Product name
Atabecestat
Purity
98.76%
Packaging
50mg
Price
$2250
Updated
2021/12/16
ChemScene
Product number
CS-0031557
Product name
Atabecestat
Purity
98.76%
Packaging
100mg
Price
$3500
Updated
2021/12/16
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Atabecestat Chemical Properties,Usage,Production

Uses

Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction. Atabecestat s tolerated and displays a sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat has the potential for Alzheimer's Disease treatment[1].

in vivo

Atabecestat (100 and 300 mg/kg; p.o. once daily for 3 days) reduces the human Aβ levels in mice[2]. Atabecestat (300 mg/kg; p.o. once) inhibits the exacerbation of vascular abnormalities in APPPS1 mice with 3D6 treatment[2].

Animal Model:5-week-old APPPS1 mice[2]
Dosage:100 and 300 mg/kg
Administration:Oral gavage; 100 and 300 mg/kg; once daily for 3 days
Result:Reduced the level of human Aβ1-40 and Aβ1-42 levels in the brain of APPPS1 mice at a dose of 300 mg/kg and resulted in less reduction of human Aβ levels at 24 h with a dose of 100 mg/kg.

IC 50

BACE1

References

[1] Timmers M, et al. Profiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ-54861911, a?potent?oral BACE inhibitor.Alzheimers Dement (N Y).?2016 Aug 24;2(3):202-212. DOI:10.1016/j.trci.2016.08.001
[2] Janssens J, et al. Passive immunotherapy with a novel antibody against 3pE-modified Aβ demonstrates potential for enhanced efficacy and favorable safety in combination with BACE inhibitor treatment in plaque-depositing mice. Neurobiol Dis. 2021 Jul;154:105365. DOI:10.1016/j.nbd.2021.105365

Atabecestat Preparation Products And Raw materials

Raw materials

Preparation Products

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Atabecestat Suppliers

China 23 United States 3 Global 26
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4768
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2991
Advantage
58
Shanghai Biopharmaleader Co., Ltd.
Tel
+86 18721201413
Fax
+86 (21) 5775-8967
Email
sales@biopharmaleader.com
Country
China
ProdList
1720
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3934
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Guangzhou Younan Technology Co., Ltd
Tel
020-82000279 18988941452
Fax
QQ：3283937693
Email
YN_research@163.com
Country
China
ProdList
3011
Advantage
58
Nanjing Shizhou Biotechnology Co., Ltd
Tel
025-0258556344 17301488900
Fax
18013869214
Email
rose.shi@synzest.com
Country
China
ProdList
271
Advantage
58

1200493-78-2, AtabecestatRelated Search:


  • Atabecestat
  • JNJ-54861911
  • Atabecestat (JNJ-54861911)
  • 2-Pyridinecarboxamide, N-[3-[(4S)-2-amino-4-methyl-4H-1,3-thiazin-4-yl]-4-fluorophenyl]-5-cyano-
  • (S)-N-(3-(2-Amino-4-methyl-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide
  • 1200493-78-2