SPHINX31

Product Name: SPHINX31
CAS No.: 1818389-84-2
Chemical Name: SPHINX31
Synonyms: CS-2837;SPHINX31;SPHINX31, 10 mM in DMSO;N-(2-(4-(Pyridin-2-ylmethyl)piperazin-1-yl)-5-(trifluoromethyl)phenyl)-5-(pyridin-4-yl)furan-2-carboxamide;2-Furancarboxamide, 5-(4-pyridinyl)-N-[2-[4-(2-pyridinylmethyl)-1-piperazinyl]-5-(trifluoromethyl)phenyl]-;Serine-arginine protein kinases,retinal permeability,eye disease,neovascular,Inhibitor,Norway Brown rats,SPHINX 31,SRPK,SPHINX31,inhibit,Vascular endothelial growth factor receptor,HuCCA-1,VEGFR,SPHINX-31,diabetics,angiogenic
CBNumber: CB63364116
Molecular Formula: C27H24F3N5O2
Formula Weight: 507.51
MOL File: 1818389-84-2.mol

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SPHINX31 Property

Boiling point:: 569.0±50.0 °C(Predicted)
Density: 1.342±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO:17.5(Max Conc. mg/mL);34.48(Max Conc. mM)
Ethanol:12.0(Max Conc. mg/mL);23.65(Max Conc. mM)
form: A crystalline solid
pka: 11.83±0.70(Predicted)
color: White to off-white
InChIKey: VURLRACCOCGFDB-UHFFFAOYSA-N
SMILES: O1C(C2C=CN=CC=2)=CC=C1C(NC1=CC(C(F)(F)F)=CC=C1N1CCN(CC2=NC=CC=C2)CC1)=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21582
Product name: SPHINX31
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 21582
Product name: SPHINX31
Purity: ≥98%
Packaging: 5mg
Price: $151
Updated: 2024/03/01

Cayman Chemical

Product number: 21582
Product name: SPHINX31
Purity: ≥98%
Packaging: 10mg
Price: $249
Updated: 2024/03/01

Cayman Chemical

Product number: 21582
Product name: SPHINX31
Purity: ≥98%
Packaging: 25mg
Price: $485
Updated: 2024/03/01

ChemScene

Product number: CS-0066777
Product name: SPHINX31
Purity: 99.17%
Packaging: 50mg
Price: $350
Updated: 2021/12/16

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SPHINX31 Chemical Properties,Usage,Production

Uses

SPHINX31 is a potent and selective SRPK1 inhibitor, with an IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1). SPHINX31 also decreases the mRNA expression of pro-angiogenic VEGF-A165a isoform. SPHINX31 can be used to research neovascular eye disease[1][2][3].

in vivo

SPHINX31 (200 μg/mL; twice daily topical eye drops) protects the retinal endothelial permeability barrier from diabetes-associated loss of integrity^[3].

Animal Model:	Norway Brown rats (intraperitoneally injected with 50 mg/kg Streptozotocin (HY-10219) to induce type I diabetes)^[3]
Dosage:	200 μg/mL
Administration:	Twice daily topical eye drops
Result:	Reduced retinal permeability in the diabetics (7.92 ± 1.65 × 10^-4 cms^-1) less than before induction of diabetes (8.15 ± 2.33 × 10^-4 cms^-1), and less than the control group (8.85 ± 1.29 × 10^-4 cms^-1), while the diabetes group was 12.67 ± 1.09 × 10^-4 cms^-1.

References

[1] Batson J, et al. Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chem Biol. 2017 Mar 17;12(3):825-832. DOI:10.1021/acschembio.6b01048
[2] Supradit K, et al. Inhibition of serine/arginine-rich protein kinase-1 (SRPK1) prevents cholangiocarcinoma cells induced angiogenesis. Toxicol In Vitro. 2022 Aug;82:105385. DOI:10.1016/j.tiv.2022.105385
[3] C. Allen, et al. The SRPK1 inhibitor SPHINX31 prevents increased retinal permeability in a rodent model of diabetes. Acta Ophthalmologica. Volume 95, Issue S259.

SPHINX31 Preparation Products And Raw materials

Raw materials

Preparation Products

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SPHINX31 Suppliers

China 61 United States 8 USA 1 Global 70

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1818389-84-2, SPHINX31Related Search:

SPHINX31

CS-2837

2-Furancarboxamide, 5-(4-pyridinyl)-N-[2-[4-(2-pyridinylmethyl)-1-piperazinyl]-5-(trifluoromethyl)phenyl]-

N-(2-(4-(Pyridin-2-ylmethyl)piperazin-1-yl)-5-(trifluoromethyl)phenyl)-5-(pyridin-4-yl)furan-2-carboxamide

Serine-arginine protein kinases,retinal permeability,eye disease,neovascular,Inhibitor,Norway Brown rats,SPHINX 31,SRPK,SPHINX31,inhibit,Vascular endothelial growth factor receptor,HuCCA-1,VEGFR,SPHINX-31,diabetics,angiogenic

SPHINX31, 10 mM in DMSO

1818389-84-2

18389-84-2