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SPHINX31

Product Name
SPHINX31
CAS No.
1818389-84-2
Chemical Name
SPHINX31
Synonyms
CS-2837;SPHINX31;SPHINX31, 10 mM in DMSO;N-(2-(4-(Pyridin-2-ylmethyl)piperazin-1-yl)-5-(trifluoromethyl)phenyl)-5-(pyridin-4-yl)furan-2-carboxamide;2-Furancarboxamide, 5-(4-pyridinyl)-N-[2-[4-(2-pyridinylmethyl)-1-piperazinyl]-5-(trifluoromethyl)phenyl]-;Serine-arginine protein kinases,retinal permeability,eye disease,neovascular,Inhibitor,Norway Brown rats,SPHINX 31,SRPK,SPHINX31,inhibit,Vascular endothelial growth factor receptor,HuCCA-1,VEGFR,SPHINX-31,diabetics,angiogenic
CBNumber
CB63364116
Molecular Formula
C27H24F3N5O2
Formula Weight
507.51
MOL File
1818389-84-2.mol
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SPHINX31 Property

Boiling point:
569.0±50.0 °C(Predicted)
Density 
1.342±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO:17.5(Max Conc. mg/mL);34.48(Max Conc. mM)
Ethanol:12.0(Max Conc. mg/mL);23.65(Max Conc. mM)
form 
A crystalline solid
pka
11.83±0.70(Predicted)
color 
White to off-white
InChIKey
VURLRACCOCGFDB-UHFFFAOYSA-N
SMILES
O1C(C2C=CN=CC=2)=CC=C1C(NC1=CC(C(F)(F)F)=CC=C1N1CCN(CC2=NC=CC=C2)CC1)=O
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21582
Product name
SPHINX31
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
21582
Product name
SPHINX31
Purity
≥98%
Packaging
5mg
Price
$151
Updated
2024/03/01
Cayman Chemical
Product number
21582
Product name
SPHINX31
Purity
≥98%
Packaging
10mg
Price
$249
Updated
2024/03/01
Cayman Chemical
Product number
21582
Product name
SPHINX31
Purity
≥98%
Packaging
25mg
Price
$485
Updated
2024/03/01
ChemScene
Product number
CS-0066777
Product name
SPHINX31
Purity
99.17%
Packaging
5mg
Price
$90
Updated
2021/12/16
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SPHINX31 Chemical Properties,Usage,Production

Uses

SPHINX31 is a potent and selective SRPK1 inhibitor, with an IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1). SPHINX31 also decreases the mRNA expression of pro-angiogenic VEGF-A165a isoform. SPHINX31 can be used to research neovascular eye disease[1][2][3].

in vivo

SPHINX31 (200 μg/mL; twice daily topical eye drops) protects the retinal endothelial permeability barrier from diabetes-associated loss of integrity[3].

Animal Model:Norway Brown rats (intraperitoneally injected with 50 mg/kg Streptozotocin (HY-10219) to induce type I diabetes)[3]
Dosage:200 μg/mL
Administration:Twice daily topical eye drops
Result:Reduced retinal permeability in the diabetics (7.92 ± 1.65 × 10-4 cms-1) less than before induction of diabetes (8.15 ± 2.33 × 10-4 cms-1), and less than the control group (8.85 ± 1.29 × 10-4 cms-1), while the diabetes group was 12.67 ± 1.09 × 10-4 cms-1.

References

[1] Batson J, et al. Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chem Biol. 2017 Mar 17;12(3):825-832. DOI:10.1021/acschembio.6b01048
[2] Supradit K, et al. Inhibition of serine/arginine-rich protein kinase-1 (SRPK1) prevents cholangiocarcinoma cells induced angiogenesis. Toxicol In Vitro. 2022 Aug;82:105385. DOI:10.1016/j.tiv.2022.105385
[3] C. Allen, et al. The SRPK1 inhibitor SPHINX31 prevents increased retinal permeability in a rodent model of diabetes. Acta Ophthalmologica. Volume 95, Issue S259.

SPHINX31 Preparation Products And Raw materials

Raw materials

Preparation Products

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SPHINX31 Suppliers

China 61 United States 8 USA 1 Global 70
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
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58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
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Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
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58
Cayman Chemical Company
Tel
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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81
Axon Medchem LLC
Tel
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Fax
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Email
info@axonmedchem.com
Country
United States
ProdList
763
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58

1818389-84-2, SPHINX31Related Search:


  • SPHINX31
  • CS-2837
  • 2-Furancarboxamide, 5-(4-pyridinyl)-N-[2-[4-(2-pyridinylmethyl)-1-piperazinyl]-5-(trifluoromethyl)phenyl]-
  • N-(2-(4-(Pyridin-2-ylmethyl)piperazin-1-yl)-5-(trifluoromethyl)phenyl)-5-(pyridin-4-yl)furan-2-carboxamide
  • Serine-arginine protein kinases,retinal permeability,eye disease,neovascular,Inhibitor,Norway Brown rats,SPHINX 31,SRPK,SPHINX31,inhibit,Vascular endothelial growth factor receptor,HuCCA-1,VEGFR,SPHINX-31,diabetics,angiogenic
  • SPHINX31, 10 mM in DMSO
  • 1818389-84-2
  • 18389-84-2