QC6352
- Product Name
- QC6352
- CAS No.
- 1851373-36-8
- Chemical Name
- QC6352
- Synonyms
- QC6352;CPD1548;QC-6352,QC6352;4-Pyridinecarboxylic acid, 3-[[[(1R)-1,2,3,4-tetrahydro-6-(methylphenylamino)-1-naphthalenyl]methyl]amino]-
- CBNumber
- CB63367975
- Molecular Formula
- C24H25N3O2
- Formula Weight
- 387.47
- MOL File
- 1851373-36-8.mol
QC6352 Property
- Boiling point:
- 681.6±55.0 °C(Predicted)
- Density
- 1.243±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 25 mg/mL (64.52 mM)
- pka
- 1.55±0.36(Predicted)
- form
- Solid
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T295920
- Product name
- 3-[[[(1R)-1,2,3,4-Tetrahydro-6-(methylphenylamino)-1-naphthalenyl]methyl]amino]-4-PyridinecarboxylicAcid
- Packaging
- 1mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- T295920
- Product name
- 3-[[[(1R)-1,2,3,4-Tetrahydro-6-(methylphenylamino)-1-naphthalenyl]methyl]amino]-4-PyridinecarboxylicAcid
- Packaging
- 2.5mg
- Price
- $430
- Updated
- 2021/12/16
- Product number
- CS-7916
- Product name
- QC6352
- Purity
- ≥98.0%
- Packaging
- 5mg
- Price
- $540
- Updated
- 2021/12/16
- Product number
- BQ166963
- Product name
- QC 6352
- Packaging
- 5mg
- Price
- $725
- Updated
- 2021/12/16
- Product number
- CS-7916
- Product name
- QC6352
- Purity
- ≥98.0%
- Packaging
- 10mg
- Price
- $900
- Updated
- 2021/12/16
QC6352 Chemical Properties,Usage,Production
Uses
3-[[[(1R)-1,2,3,4-Tetrahydro-6-(methylphenylamino)-1-naphthalenyl]methyl]amino]-4-Pyridinecarboxylic Acid is also known as a KDM4 inhibitor exhibiting antiproliferative effects in cancer models.
in vivo
QC6352 strongly affects tumor growth and final tumor weight of both BCSC1 and BCSC2 xenografts. Treatment with QC6352 is well tolerated and does not affect body weight of the mice. Results demonstrate that treatment with the KDM4 inhibitor QC6352 blocks BCSC xenograft tumor growth[2].
IC 50
KDM4; KDM5B: 750 nM (IC50); KDM4A: 104 nM (IC50); KDM4B: 56 nM (IC50); KDM4C: 35 nM (IC50); KDM4D: 104 nM (IC50)
QC6352 Preparation Products And Raw materials
Raw materials
Preparation Products
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