Cyclo[(4S)-2-(1-amino-2-methylpropyl)-4-thiazolecarbonyl-D-valyl-L-tryptophyl-D-leucyl-L-valyl-D-valyl]
- Product Name
- Cyclo[(4S)-2-(1-amino-2-methylpropyl)-4-thiazolecarbonyl-D-valyl-L-tryptophyl-D-leucyl-L-valyl-D-valyl]
- CAS No.
- 1989698-37-4
- Chemical Name
- Cyclo[(4S)-2-(1-amino-2-methylpropyl)-4-thiazolecarbonyl-D-valyl-L-tryptophyl-D-leucyl-L-valyl-D-valyl]
- Synonyms
- Lugdunin;Cyclo[(4S)-2-(1-amino-2-methylpropyl)-4-thiazolecarbonyl-D-valyl-L-tryptophyl-D-leucyl-L-valyl-D-valyl]
- CBNumber
- CB63370393
- Molecular Formula
- C40H62N8O6S
- Formula Weight
- 783.04
- MOL File
- 1989698-37-4.mol
Cyclo[(4S)-2-(1-amino-2-methylpropyl)-4-thiazolecarbonyl-D-valyl-L-tryptophyl-D-leucyl-L-valyl-D-valyl] Property
- Boiling point:
- 1129.4±65.0 °C(Predicted)
- Density
- 1.103±0.06 g/cm3(Predicted)
- pka
- 13.23±0.70(Predicted)
- form
- Solid
- color
- White to off-white
Cyclo[(4S)-2-(1-amino-2-methylpropyl)-4-thiazolecarbonyl-D-valyl-L-tryptophyl-D-leucyl-L-valyl-D-valyl] Chemical Properties,Usage,Production
Uses
Lugdunin is an antibiotic peptide. Lugdunin inhibits bacteria by dissipating their membrane potential. Lugdunin is active against Gram-positive bacteria, such as S. aureus, and reduces S. aureus skin and nasal colonization. Lugdunin induces LL-37 and CXCL8/MIP-2 in human keratinocytes and mouse skin[1].
Definition
ChEBI: Lugdunin is a thiazolidine-containing homodetic cyclic peptide that is isolated from human nasal bacteria. Exhibits bactericidal activity against many major pathogens including methicillin-resistant Staphylococcus aureus (MRSA). It has a role as a rat metabolite and a human metabolite. It is a homodetic cyclic peptide, a macrocycle, a member of thiazolidines, a member of indoles and a peptide antibiotic.
References
[1] Bitschar K, et al. Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors. Nat Commun. 2019 Jun 21;10(1):2730. DOI:10.1038/s41467-019-10646-7
Cyclo[(4S)-2-(1-amino-2-methylpropyl)-4-thiazolecarbonyl-D-valyl-L-tryptophyl-D-leucyl-L-valyl-D-valyl] Preparation Products And Raw materials
Raw materials
Preparation Products
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