Mc-Val-Ala-PAB

Product Name: Mc-Val-Ala-PAB
CAS No.: 1870916-87-2
Chemical Name: Mc-Val-Ala-PAB
Synonyms: Mc-Val-Ala-PAB-OH;Mc-Val-Ala-PAB;Mc ?Val ?Ala ?PAB,Inhibitor,ADC Linkers,Mc?Val?Ala?PAB,Antibody-drug conjugates linkers,inhibit;N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N-[4-(hydroxymethyl)phenyl]-L-alaninamide;L-Alaninamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N-[4-(hydroxymethyl)phenyl]-;6-(2,5-dioxopyrrol-1-yl)-N-[(2S)-1-[[(2S)-1-[4-(hydroxymethyl)anilino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]hexanamide;6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-[(1S)-1-{[(1S)-1-[(4-(hydroxymethyl)phenyl)carbamoyl]ethyl]carbamoyl}-2-methylpropyl]hexanamide;6-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)-N-[(S)-1-[[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-2-propyl]amino]-3-methyl-1-oxo-2-butyl]hexanamide;6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide
CBNumber: CB63373066
Molecular Formula: C25H34N4O6
Formula Weight: 486.56
MOL File: 1870916-87-2.mol

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Mc-Val-Ala-PAB Property

Boiling point:: 828.6±65.0 °C(Predicted)
Density: 1.249±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO: Sparingly soluble: 1-10 mg/ml
form: Solid
pka: 13.48±0.70(Predicted)
color: Off-white to yellow
InChIKey: BNBPKWDHHBIUIY-SBUREZEXSA-N
SMILES: C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(CO)C=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0103020
Product name: Mc-Val-Ala-PAB
Packaging: 100mg
Price: $630
Updated: 2021/12/16

Iris Biotech GmbH

Product number: ADC1270
Product name: MC-Val-Ala-PAB
Packaging: 1g
Price: $1215
Updated: 2021/12/16

Ambeed

Product number: A1196787
Product name: 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide
Purity: 98+%
Packaging: 50mg
Price: $115
Updated: 2021/12/16

Ambeed

Product number: A1196787
Product name: 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide
Purity: 98+%
Packaging: 100mg
Price: $189
Updated: 2021/12/16

Ambeed

Product number: A1196787
Product name: 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide
Purity: 98+%
Packaging: 250mg
Price: $320
Updated: 2021/12/16

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Mc-Val-Ala-PAB Chemical Properties,Usage,Production

Uses

Mc- Val- Ala- PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

IC 50

Protease Cleavable Linker; Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] DAPENG LI . AGCM-22, a novel cetuximab-based EGFR-targeting antibody-drug-conjugate with highly selective anti-glioblastoma efficacy[J]. Bioorganic & Medicinal Chemistry, 2024, 102: Article 117657. DOI: 10.1016/j.bmc.2024.117657
[3] SHIYONG FAN . Novel antibody-antibiotic conjugate using KRM-1657 as payload eliminates intracellular MRSA in vitro and in vivo[J]. Bioorganic Chemistry, 2024, 150: Article 107532. DOI: 10.1016/j.bioorg.2024.107532

Mc-Val-Ala-PAB Preparation Products And Raw materials

Raw materials

Preparation Products

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Mc-Val-Ala-PAB Suppliers

China 81 United States 6 Global 87

Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd.

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Email: info@topbiochem.com
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T&W GROUP

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Nanjing Leon Biological Technology Co., Ltd.

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1870916-87-2, Mc-Val-Ala-PABRelated Search:

Mc-Val-Ala-PAB

L-Alaninamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N-[4-(hydroxymethyl)phenyl]-

Mc-Val-Ala-PAB-OH

6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide

Mc ?Val ?Ala ?PAB,Inhibitor,ADC Linkers,Mc?Val?Ala?PAB,Antibody-drug conjugates linkers,inhibit

6-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)-N-[(S)-1-[[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-2-propyl]amino]-3-methyl-1-oxo-2-butyl]hexanamide

6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-[(1S)-1-{[(1S)-1-[(4-(hydroxymethyl)phenyl)carbamoyl]ethyl]carbamoyl}-2-methylpropyl]hexanamide

N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N-[4-(hydroxymethyl)phenyl]-L-alaninamide

6-(2,5-dioxopyrrol-1-yl)-N-[(2S)-1-[[(2S)-1-[4-(hydroxymethyl)anilino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]hexanamide

1870916-87-2

Linker

ADC LINKER